Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)SARS-CoV-2 백신 부스터 후 2주간 저용량 메토트렉세이트 치료를 일시적으로 중단하는 것이 염증성 질환이 있는 면역억제 성인의 백신 반응에 미치는 영향: 다기관 무작위 대조 시험 및 중첩 기전 하위 연구 프로토콜(Vaccine Response On/Off Methotrexate(VROOM) ) 공부하다)Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 adjusted Analysis Anti-spike antibody approved Arm ARMS assessment Autoimmune B-cell baseline biochemical booster booster vaccination clinical trials clinics collected conducted conferences COVID-19 Dermatology disease Disease activity domain Effect ENhance Ethics ethics committee evaluate Factor feasibility group Health Research Authority immune response Immunosuppressed IMPROVE Inflammatory inflammatory conditions Intention intention to treat Intervention investigated IRAS low-dose main outcome measure memory methotrexate multicentre neutralising antibody titre Open-label Other parallel group participant Participants Patient peer review performed Pragmatic Primary outcome protocol randomisation randomised randomised controlled randomised controlled trial RBD REC registration number repeated measure repeated measures required Research Ethics response Result rheumatology Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary outcome secondary outcome measure subject T-cell Response Treatment Trial UK hospitals usual care vaccination against COVID-19 vaccine response West written Informed Consent [DOI] 10.1136/bmjopen-2022-062599 PMC 바로가기 [Article Type] Article
Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational studyObservational Study Published on 2022-05-012022-10-04 Journal: The Lancet. Public Health [Category] Fulltext, MERS, 유전자 메커니즘, 임상, [키워드] acute COVID-19 acute infection Anxiety Cohort cohort analysis consequence Council country COVID COVID-19 COVID-19 diagnosis COVID-19 severity COVID-19-related distress cross-sectional analysis Denmark Depression diagnosed diagnosed with COVID-19 Diagnosis diagnosis of COVID-19 disease eligible Estonia Estonian Follow-up follow-up study General population Health higher risk Iceland individual individuals lower risk Mental mental health morbidity non-hospitalised Norway Older participant Patient patient population patients with COVID-19 physical Prevalence public health recruited repeated measure screened Seven severity sleep quality study period Symptom symptoms of depression trajectory Wellcome Trust [DOI] 10.1016/S2468-2667(22)00042-1 PMC 바로가기 [Article Type] Observational Study
Supporting business educators and students against COVID-19 trauma using trauma-focused cognitive behavioral therapyRandomized Controlled Trial Published on 2022-04-082022-10-05 Journal: Medicine [Category] 임상, [키워드] adverse effect Anxiety arising assigned cognitive control groups Coping strategy coronavirus COVID-19 COVID-19 pandemic Depression distress Effect Factor Follow-up Gender indicated Intervention mental health mental health problem Nigeria no significant difference outbreak outcome participant Participants Post-traumatic stress disorder Psychological PTSD questionnaire Randomly reduced repeated measure Research significantly Study participants Support Supporting Symptom therapy trauma Treatment treatment group variance was used [DOI] 10.1097/MD.0000000000029133 PMC 바로가기 [Article Type] Randomized Controlled Trial
Comparison of SARS-CoV-2 anti-spike receptor binding domain IgG antibody responses after CoronaVac, BNT162b2, ChAdOx1 COVID-19 vaccines, and a single booster dose: a prospective, longitudinal population-based studyCoronaVac, BNT162b2, ChAdOx1 COVID-19 백신 및 단일 추가 접종 후 SARS-CoV-2 anti-spike 수용체 결합 도메인 IgG 항체 반응의 비교: 전향적, 종단적 인구 기반 연구Article Published on 2022-04-012022-09-12 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI addition age Anti-spike Anti-spike RBD IgG antibody antibody level Antibody Response Antibody titre antibody titres baseline characteristics blood sample BNT162b2 boost booster booster dose ChAdOx1 ChAdOx1 vaccines collected concentrations CoronaVac COVID-19 pandemic COVID-19 vaccines Cyprus distribution dose evaluated Follow-up General population geometric group health-care help high-risk population highest IgG IgG antibody individual inoculated Laboratory Longitudinal data Male sex of BNT162b2 offered Older Older age participant RBD Reactions Receptor binding domain recruited regimen repeated measure Responder response SARS-CoV-2 second dose significantly significantly increased titre vaccination Vaccination strategies Vaccine was done [DOI] 10.1016/S2666-5247(21)00305-0 PMC 바로가기 [Article Type] Article
Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab중화 단일클론항체 밤라니비맙 치료 후 코로나19로 입원한 환자의 비인두 면봉 유전자 발현 패턴과 혈청 바이오마커 간의 관계Randomized Controlled Trial Published on 2022-03-182022-09-11 Journal: Journal of Translational Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] absence Analysis Analytes antibody formation Antibody Response approach bamlanivimab Biomarker biomarker signature Biomarkers Blood change changes in circulation clinical clinical trial Cohort collected connection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCL10 CXCL11 detect disease Elecsys Gene Expression gene expression pattern groups healthy control healthy controls Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients IFNγ IgA IgG titer IgG titers IgM IL-6 immune response immunoassay immunological implementation Infection Inflammatory inflammatory protein Inflammatory response interferon response Level Luminex MCP-3 MONITOR monoclonal antibody nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharyngeal swabs Neutralizing not affect not significantly different observation observations Patient patient population patients patients hospitalized patients with COVID-19 peaked Peripheral blood Placebo presence or absence profile Protein Randomized receive reductions reductions in relationship remained repeated measure respiratory RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection Seroconversion serology serum serum biomarker Serum protein serum proteins serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarities single dose systemic disease therapeutic Treatment Treatment strategies utility viral-induced was performed was used were used while with COVID-19 [DOI] 10.1186/s12967-022-03345-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Identifying Factors That Predict Behavioral Intention to Stay under Lockdown during the SARS-CoV-2 Pandemic Using a Structural Equation ModelArticle Published on 2022-02-272022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome applied Attitude CFI Compliance component conducted coronavirus equation explained Factor identify identifying Infection Intention Isolation lockdown Model pandemic participant positive positive attitude predict Predictive promote quarantine repeated measure sampling SARS-CoV-2 social distancing Spread Support the SARS-CoV-2 variable [DOI] 10.3390/ijerph19052757 PMC 바로가기 [Article Type] Article
Effects of a taped filter mask on peak power, perceived breathlessness, heart rate, blood lactate and oxygen saturation during a graded exercise test in young healthy adults: a randomized controlled trialResearch Published on 2022-02-072022-10-27 Journal: BMC Sports Science, Medicine and Rehabilitation [Category] COVID-19, [키워드] analysed Blood breathlessness Concentration COVID-19 Effect effective evaluate Exercise capacity Exercise test face Face mask females healthy heart rate intensity Lactate less Mask Masks moderate oxygen saturation parameters participant Pathogens peak power performed peripheral oxygen saturation questionnaire Randomized controlled trial reduce reduced repeated measure respiratory Result SARS-CoV-2 sealed significantly subject supplementary material surgical T-tests Transmission Ventilation volitional [DOI] 10.1186/s13102-022-00410-8 PMC 바로가기 [Article Type] Research
Impact of Prolonged Absence of Organized Training on Body Composition, Neuromuscular Performance, and Aerobic Capacity: A Study in Youth Male Soccer Players Exposed to COVID-19 LockdownArticle Published on 2022-01-202022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] absence aerobic age Analysis ANOVA Athletic performance Body body composition Body fat percentage calculated category changed COVID-19 decrement detraining detrimental evaluated Football IBM Impact male Neuromuscular New York organized participated performance performed physical Prolonged prospective cohort study reliability repeated repeated measure significance level Significant SPSS stay at home orders training USA was performed was used Youth youth football [DOI] 10.3390/ijerph19031148 PMC 바로가기 [Article Type] Article
Covid-19 and the quality of life of people with dementia and their carers—The TFD-C19 studyResearch Article Published on 2022-01-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] age ANOVA baseline Care carried changed clinical cognitive cohort study COVID-19 Dementia Evidence Gender group Health life lockdown measure National outcome pandemic participant Quality Quality of life reduced repeated measure Resilience Result scale severity significantly subgroup Support These data variable Variation [DOI] 10.1371/journal.pone.0262475 PMC 바로가기 [Article Type] Research Article
Ivermectin shows clinical benefits in mild to moderate COVID19: a randomized controlled double-blind, dose-response study in LagosRandomized Controlled Trial Published on 2022-01-052022-10-05 Journal: QJM: An International Journal of Medicine [Category] SARS, 임상, [키워드] 95%CI ANOVA clinical benefit Clinical management conducted Control controls correlated COVID COVID 19 COVID19 Day dose dose response double blind double-blind Efficacy Efficacy and safety group high risk inhibit Lago Lopinavir/ritonavir Mild moderate negativity parallel group Patient Placebo Platelet positive patients Prophylaxis question Randomized reduced remained repeated measure reported SAE shown significantly the SARS-CoV-2 translational Treatment treatment groups viral replication [DOI] 10.1093/qjmed/hcab035 PMC 바로가기 [Article Type] Randomized Controlled Trial