Development and Analytical Validation of a One-Step Five-Plex RT-ddPCR Assay for the Quantification of SARS-CoV-2 Transcripts in Clinical SamplesArticle Published on 2022-09-132022-11-16 Journal: Analytical Chemistry [Category] SARS, 치료기술, [키워드] analytical sensitivity Analytical specificity analyzed applied calibrator Characteristics clinical Concordance controls correlation COVID-19 pandemic development Direct DNA and RNA in-silico Inclusion Internal control linear methodology Metrics molecular primer probe provide Quality control quantification Region reproducibility RNA RT-qPCR Sample SARS-CoV-2 SARS-CoV-2 detection sensitivity Spearman specimen Standardization transcripts validation viral concentrations [DOI] 10.1021/acs.analchem.2c00868 PMC 바로가기
Role of Breath Biopsy in COVID-19Article Published on 2022-09-012022-11-15 Journal: The journal of applied laboratory medicine [Category] 바이오마커, [키워드] affected Analysis approach biochemical Biomarker Biomarkers biopsy breath breath analyzers caused contagious country Coverage COVID-19 COVID-19 diagnosis diagnosis of COVID-19 healthcare mass spectrometry. noninvasive reproducibility Respiratory disease role SARS-CoV-2 sensitivity specificity transmitted VOCs [DOI] 10.1093/jalm/jfac040 PMC 바로가기
BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor DiscoveryArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cells 3C-like protease 3CLpro Activation activity anti-SARS-CoV-2 activities Antiviral biosensor BRET BSL-2 BSL-2 laboratory BSL-3 C-terminus can be used Cell cellular cleavage clinical trial coronavirus diseases COVID-19 COVID-19 treatments decrease drug target embryonic kidney energy transfer evaluate evaluated fluorescent inhibitor inhibitors level 3 linker N-terminus overexpression polyproteins protease Protein released Renilla luciferase reported reproducibility restored resulting SARS-CoV-2 self-cleavage self-cleaving biosensor. sequence small molecule inhibitor treat virus [DOI] 10.1128/spectrum.02559-21 PMC 바로가기
Reproducibility of real-world evidence studies using clinical practice data to inform regulatory and coverage decisions Research Published on 2022-08-312022-10-05 Journal: Nature Communications [Category] 임상, [키워드] aligned Analysis Clinical practice collected Completeness Coverage database Effect effect size effective Ensuring evaluate Evidence explained generate Guidance healthcare IMPROVE interquartile range investigator magnitude majority median methodological original peer-reviewed positively correlated Regulatory reproducibility subset Validity while [DOI] 10.1038/s41467-022-32310-3 [Article Type] Research
Planning and Reporting Effective Web-Based RAND/UCLA Appropriateness Method Panels: Literature Review and Preliminary RecommendationsArticle Published on 2022-08-262022-11-16 Journal: Journal of Medical Internet Research [Category] 변종, [키워드] Affair approach Care category Characteristics Clinical presentations Clinicians Conducting COVID-19 pandemic Critical database de-implementation DelPhi Department Digital health elicit eligibility criteria evaluate Evidence example Guidance Health Health care health research Health technology identify IMPROVE involved less literature literature review measure medical professionals participant Planning primary care producing quality indicators RAND/UCLA appropriateness method recommendation reported Reporting reproducibility Research Research design researcher researchers review Safe Satisfaction searched seeking study outcomes the median Treatment variant veteran Virtual virtual health research Web-based. while [DOI] 10.2196/33898 PMC 바로가기
Development of a panel of three multiplex allele-specific qRT-PCR assays for quick differentiation of recombinant variants and Omicron subvariants of SARS-CoV-2Article Published on 2022-08-182022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술, 치료제, [키워드] allele allele-specific qRT-PCR amplification analytical sensitivity applied BA.1 subvariant BA.2 subvariant circulating variant coefficient costly CVs development Efficiency exhibited Limits of detection linear MONITOR multiplex mutated Mutation omicron Omicron variant qRT-PCR qRT-PCR assay reaction real time recombinant variant. reproducibility required RT-PCR Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant Sequencing sequencing method SNP genotyping time-consuming Transmission variant variants variants of SARS-CoV-2 Variation whole genome [DOI] 10.3389/fcimb.2022.953027 PMC 바로가기
Lightweight Distributed Provenance Model for Complex Real–world Environments Research Published on 2022-08-172022-10-05 Journal: Scientific Data [Category] 진단, [키워드] acquisition annotations Clinical data Complete complex contribute dataset demonstrated Dependant domain Environment form histological information Lightweight Lineage Model organizations provenance reproducibility Research specimen [DOI] 10.1038/s41597-022-01537-6 [Article Type] Research
SARS-CoV-2 spike protein detection using slightly tapered no-core fiber-based optical transducer약간 테이퍼진 노코어 광섬유 기반 광 변환기를 사용한 SARS-CoV-2 스파이크 단백질 검출Article Published on 2022-08-062022-09-11 Journal: Mikrochimica Acta [Category] SARS, 치료기술, [키워드] ACE2 adopted Antigen binding buffer cause changes in Concentration COVID-19 cross-reactivity demonstrated Detection sensitivity effective expected facilitate fiber lAbel medium MERS MERS-CoV modulation No-core fiber optical Optical fiber Optical fiber biosensor platform probe Protein protocol reconstructed refractive index reproducibility Saliva SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein selective Spike protein Tapered optical fiber. Transmission was selected [DOI] 10.1007/s00604-022-05413-3 PMC 바로가기 [Article Type] Article
Assessing and improving the validity of COVID-19 autopsy studies – A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analysesResearch article Published on 2022-08-022022-10-05 Journal: EBioMedicine [Category] Coronavirus, SARS, 치료기술, [키워드] Alliance Analysis analysis antibody approach Assessing Autopsy autopsy study available data Berlin cell line cellular structure center correlated COVID-19 criteria education Effect Effects electron microscopy evaluated finding foundation funding Guidance help high variability highest IHC immune response immunohistochemistry Interpretation Microscopy Ministry of Health multicentre organ organ damage pathology pathophysiology positive correlation Protein provided Quantitative recommendation reproducibility RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid SARS-CoV-2 viral RNA Sensitivity and specificity specificity the SARS-CoV-2 tissue tissues university Validity Variability Viral protein virus [DOI] 10.1016/j.ebiom.2022.104193 [Article Type] Research article
A reverse-transcription droplet digital PCR assay to detect and quantify SARS-CoV-2 RNA in upper respiratory tract specimens상기도 표본에서 SARS-CoV-2 RNA를 검출하고 정량화하기 위한 역전사 액적 디지털 PCR 분석Article Published on 2022-08-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analytical sensitivity Analytical specificity assays Asymptomatic cause coronavirus coronavirus disease Coronavirus disease 2019 coronavirus strain correlation COVID-19 cross-reactivity detect digital PCR droplet droplet digital PCR Efficacy evaluated healthy Immunocompromised patients linear linearity Mild N1 and N2 nasopharyngeal oropharyngeal swab Patient Pneumonia positive-sense Qualitative quantification Quantitative quantitative assay R 2 reproducibility respiratory tract RNA RNA quantification RNA virus SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-stranded RNA virus specimen targets therapy for COVID-19 upper respiratory tract variety Viral load viral transport media [DOI] 10.1016/j.jcv.2022.105216 PMC 바로가기 [Article Type] Article