Effect of a home-based inspiratory muscular training programme on functional capacity in patients with chronic COVID-19 after a hospital discharge: protocol for a randomised control trial (InsCOVID trial)퇴원 후 만성 COVID-19 환자의 기능 능력에 대한 가정 기반 흡기 근육 훈련 프로그램의 효과: 무작위 대조 시험 프로토콜(InsCOVID 시험)Article Published on 2022-07-012022-09-11 Journal: BMJ Open Respiratory Research [Category] 임상, [키워드] 1:1 acute respiratory syndrome acute respiratory syndrome coronavirus Admission analysis of variance approved baseline blinded coronavirus COVID-19 COVID-19 patients Declaration of Helsinki discharged Effect eight eligible patient enrolled Ethics evaluate exercise exercise intolerance fatigue finding functional functional capacity groups Helsinki hospital Hospital admission hospital discharge IMPROVE inspiratory muscle Intervention muscles muscular National outcome Patient peer-reviewed Pneumonia primary endpoint protocol pulmonary rehabilitation randomised randomised controlled trial receive registration number Regulation Research Research Ethics Research Ethics Committee respiratory muscles Supervised exercise Symptom symptomatic Symptoms the primary endpoint Trial usual care usual care alone variance [DOI] 10.1136/bmjresp-2022-001255 PMC 바로가기 [Article Type] Article
Developing and Implementing Electronic Consent Procedures in Response to Covid-19 RestrictionsCovid-19 제한에 대응하는 전자 동의 절차 개발 및 구현Article Published on 2022-07-012022-09-11 Journal: Ethics & human research [Category] 임상, [키워드] activity assent Complete Confusion Consent COVID-19 pandemic develop Developing electronic informed consent enrolled Families human research ethics human subjects research hybrid Implementing individual Informed consent informed consent. interactions lesson manuscript multisite pandemic participant pediatric procedure Research Research Ethics response restriction subject tested the United State trauma Trial type III United States utilization [DOI] 10.1002/eahr.500135 PMC 바로가기 [Article Type] Article
A new day for human challenge trials?Review Published on 2022-07-012023-07-09 Journal: Trends in molecular medicine [Category] COVID19(2023년), [키워드] Controlled human infection model COVID-19 human challenge trials Research Ethics vaccine ethics [DOI] 10.1016/j.molmed.2022.05.002 PMC 바로가기 [Article Type] Review
Ethical reflections on Covid-19 vaccinesArticle Published on 2022-06-012023-07-06 Journal: Acta clinica Belgica [Category] COVID19(2023년), [키워드] COVID-19 Public health ethics Research Ethics SARS CoV-2 vaccination [DOI] 10.1080/17843286.2021.1925027
Rationale and Design for the LOnger-term effects of SARS-CoV-2 INfection on blood Vessels And blood pRessure (LOCHINVAR): an observational phenotyping study혈관 및 혈압(LOCHINVAR)에 대한 SARS-CoV-2 감염의 장기 효과에 대한 이론적 근거 및 설계: 관찰 표현형 연구Observational Study Published on 2022-06-012022-09-11 Journal: Open Heart [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] All participant All participants All study participants angiotensin approved baseline Biomarkers Blood blood pressure blood sample Blood samples blood vessels brachial calculated Confirmed COVID-19 infection consequence Control controls COVID-19 COVID-19 infection detect discharge Effect Elizabeth endothelial Endothelium Ethics ethics committee Evidence evidence of Hospital admission hypertension Immune status include individual Interaction International mean difference medication Myocardial infarction normal blood pressure participant Patient peer-reviewed pilot study Primary outcome protocol provided rationale recruited registration number Renin renin-angiotensin system Research Research design Research Ethics Research Ethics Committee Sample Sample size SARS-CoV-2 SARS-COV-2 infection SBP stroke Study participants submitted systolic undergo university Urine Vascular vascular inflammation West with COVID-19 written Informed Consent [DOI] 10.1136/openhrt-2022-002057 PMC 바로가기 [Article Type] Observational Study
Meditation and yoga for irritable bowel syndrome: study protocol for a randomised clinical trial (MY-IBS study)과민성 대장 증후군에 대한 명상과 요가: 무작위 임상 시험을 위한 연구 프로토콜(MY-IBS 연구)Article Published on 2022-05-262022-09-11 Journal: BMJ Open [Category] 임상, [키워드] active control group Anxiety approved attrition rates baseline board bowel clinical clinical trial clinical trials conducted Conjoint Health Research Ethics Board control group Controlled trial Depression determine diagnosed Effect effective Effectiveness Ethics evaluated facilitator fatigue feasibility finding Functional bowel disorders IBS identify include Intervention irritable bowel syndrome life media meditation mental health mind not limited office participant peer-reviewed post intervention Primary outcome Quality of life randomised randomised controlled trial REB receive recruitment registration number Research Research Ethics Satisfaction secondary outcome shown social media Stress Study protocol symptom severity Symptoms syndrome team therapeutic option yoga [DOI] 10.1136/bmjopen-2021-059604 PMC 바로가기 [Article Type] Article
Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)SARS-CoV-2 백신 부스터 후 2주간 저용량 메토트렉세이트 치료를 일시적으로 중단하는 것이 염증성 질환이 있는 면역억제 성인의 백신 반응에 미치는 영향: 다기관 무작위 대조 시험 및 중첩 기전 하위 연구 프로토콜(Vaccine Response On/Off Methotrexate(VROOM) ) 공부하다)Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 adjusted Analysis Anti-spike antibody approved Arm ARMS assessment Autoimmune B-cell baseline biochemical booster booster vaccination clinical trials clinics collected conducted conferences COVID-19 Dermatology disease Disease activity domain Effect ENhance Ethics ethics committee evaluate Factor feasibility group Health Research Authority immune response Immunosuppressed IMPROVE Inflammatory inflammatory conditions Intention intention to treat Intervention investigated IRAS low-dose main outcome measure memory methotrexate multicentre neutralising antibody titre Open-label Other parallel group participant Participants Patient peer review performed Pragmatic Primary outcome protocol randomisation randomised randomised controlled randomised controlled trial RBD REC registration number repeated measure repeated measures required Research Ethics response Result rheumatology Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary outcome secondary outcome measure subject T-cell Response Treatment Trial UK hospitals usual care vaccination against COVID-19 vaccine response West written Informed Consent [DOI] 10.1136/bmjopen-2022-062599 PMC 바로가기 [Article Type] Article
Very early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial고위험 비-ST 상승 심근경색증에서 초기 침습성 혈관조영술과 표준 치료 비교: 전향적 다기관 무작위 대조 RAPID N-STEMI 시험을 위한 연구 프로토콜Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] 임상, [키워드] all-cause mortality Analysis approved bleeding Cambridge Clinical outcome clinical outcomes completion Coronary coronary angiography Coronary heart disease coronary intervention COVID-19 pandemic defined determine East East of England England enrolled enrolment Ethics ethics committee event event rates expected heart disease heart failure Hospital admission Hypothesis IMPROVE include Infarct invasive Ischaemic heart disease major bleeding mechanistic data multicentre Myocardial Myocardial infarction Neutral Open-label participant Patient patients Percutaneous coronary intervention Pragmatic Primary outcome proportion randomised randomised controlled recommendation registration number registry Research Ethics retrospective secondary outcome Sponsor Standard of care stroke Study protocol submitted Trial trials within 6 months [DOI] 10.1136/bmjopen-2021-055878 PMC 바로가기 [Article Type] Article
Ethical Considerations in Oncology and Palliative Care Research During COVID-19COVID-19 기간 동안 종양학 및 완화 치료 연구의 윤리적 고려 사항Randomized Controlled Trial Published on 2022-05-012022-09-11 Journal: Journal of pediatric hematology/oncology nursing [Category] 비임상, 임상, [키워드] activity adhere approach assist breath Cancer Care challenge children clinical trial clinician conducted convenience coronavirus COVID-19 COVID-19 pandemic declined disadvantage Disadvantages eligible example Facebook family member healthcare information Interaction Intervention investigator Justice life-limiting modify oncology palliative pandemic pediatric Population preference protocol randomized clinical trial receive recruitment reduce required Research Research design Research Ethics researcher Result review risk subject virtual research. [DOI] 10.1177/27527530221073298 PMC 바로가기 [Article Type] Randomized Controlled Trial
Light acupuncture and five-element music therapy for nurses’ mental health and well-being during and post-COVID-19: protocol for a randomised cross-over feasibility study코로나19 기간 및 이후 간호사의 정신 건강과 웰빙을 위한 가벼운 침술 및 5요소 음악 요법: 무작위 교차 타당성 연구를 위한 프로토콜Article Published on 2022-04-292022-09-11 Journal: BMJ Open [Category] 임상, [키워드] affected Analysis Anxiety asked assessments Blinding clinical clinical trial Combination Community Complete COVID-19 pandemic cross-over Depression depression & dissemination Edith eligible engage Ethical approval Ethics ethics committee evaluate Evidence feasibility Feasibility study form Health healthcare professionals hospital Human Impact IMPROVE include Intention International Intervention Laser Laser therapy LIGHT Local management mental health mood disorders music therapy National New Nurse online questionnaire online questionnaires PAIN MANAGEMENT participant peer-reviewed performed Primary outcome profession protocol Quality of life randomised recruited registration number required Research Ethics research findings resulting secondary outcome Secondary outcomes Studio therapeutic effect therapy Treatment treatment group Trial Two-arm university Well-being [DOI] 10.1136/bmjopen-2021-057106 PMC 바로가기 [Article Type] Article