Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus서아프리카 Anopheles의 pirimiphos-methyl에 대한 내성은 Ace1 유전자좌의 복제 및 유전자이입을 통해 확산되고 있습니다.Research Article Published on 2021-01-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] ACE1 acetylcholinesterase African Analysis Anophele Anopheles gambiae approach association Carbamate Combination complex Control copy number diagnostic dominant driven by duplication duplications effective Effectiveness enzyme Genetic genomes genomic Haplotype highlight increasingly insecticidal insecticide insecticides Intervention locus malaria malaria vector molecular Mutation Non-synonymous occur organophosphate overcome phenotypic pirimiphos-methyl Population populations Predictive Predictive value predictor Prevent provide public health reduce Replication resistance resistance mechanism resistance mechanisms selection pressure sequenced specimen Spread sub-Saharan Africa Surveillance transferred Transmission unique Variation vector vectors West whole genome [DOI] 10.1371/journal.pgen.1009253 PMC 바로가기 [Article Type] Research Article
MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronavirusesReport Published on 2020-10-092022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] activating acute respiratory syndrome Antigen presentation Antiviral antiviral activity antiviral therapies canonical cathepsin-dependent CD74 Cell cellular mechanism CIITA complex coronavirus Coronaviruses Defense disease disrupt Ebola Ebola virus endosomal entry endosomal entry pathway expression Factor Filovirus glycoprotein histocompatibility complex Host human cell line human cells identify in viral induce inhibit involved isoform MHC MHC class outbreak Pathogens Prevent Protein recent resistance mechanism restriction factor SARS virus SARS-CoV-2 SARS-like coronavirus Science screening strategy the major histocompatibility therapeutic option transcription factor Treatment viral entry viral infections virus viruses well [DOI] 10.1126/science.abb3753 PMC 바로가기 [Article Type] Report
Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides기초 인간 곰팡이 병원체 Mucor circinelloides에서 RNAi 의존성 후성 돌연변이에 의해 매개되는 광범위한 항진균제 내성Research Article Published on 2019-02-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation Analysis antifungal agent antifungal agents antifungal drug resistance cause clinically demonstrated develop drug drug resistance drug target drugs enzyme Enzymes Evolution FK506 fungal Fungal infection fungi Genes high mortality IMPROVE induce Infection mechanism Mucor Mucormycosis Mutation novel passage pathogen Pathogenesis Proteins Rapamycin resistance mechanism response restored reversion RNA RNA expression RNA interference RNAi RNAi pathway selected sensitivity small RNA sRNA strain target gene treat Treatment variety [DOI] 10.1371/journal.pgen.1007957 PMC 바로가기 [Article Type] Research Article
Genome-wide CRISPR-dCas9 screens in E . coli identify essential genes and phage host factorsE의 게놈 전체 CRISPR-dCas9 스크린. 대장균은 필수 유전자와 파지 숙주 인자를 식별합니다.Research Article Published on 2018-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition applied Bacteria Bacterial bacterial capsule bacterial gene bacterial genes bacteriophage bacteriophages capsids Cas9 Cas9 RNA-guided nuclease catalytic Cell chromosome colanic acid convenience CRISPR CRISPR-Ca CRISPR-dCas9 screen CRISPRi dCas9 dCas9 protein detect E . coli expression level Factor functional Gene Expression Genes Genetic genetic interactions genetic screens Genome genomes growth guide RNA High-throughput genetic screen High-throughput genetic screens highlight highlighting Host identify infection process Interaction involved kill library mechanism medium modulate mutant over pathway phage phage λ phages phages λ phenotype Phenotypes Plasmid powerful tool predict progeny random remained reported required resistance mechanism Screen sgRNA sgRNAs technique tested transduction assay utility [DOI] 10.1371/journal.pgen.1007749 PMC 바로가기 [Article Type] Research Article
The Tomato Yellow Leaf Curl Virus Resistance Genes Ty-1 and Ty-3 Are Allelic and Code for DFDGD-Class RNA–Dependent RNA Polymerases토마토 황엽말림 바이러스 내성 유전자 Ty-1 및 Ty-3은 대립유전자이고 DFDGD-Class RNA-Dependent RNA 중합효소에 대한 코드입니다Research Article Published on 2013-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles allelic amplification approach atypical DFDGD motif Author begomovirus begomovirus species Breeding catalytic DLDGD motif catalytic domain cause caused characterized chromosomal region chromosome chromosome 6 class code Combination described different disease geminivirus geminiviruses Gene gene functions genomic region inbred lines induced introgression leaf mapped marker mechanism molecular molecular markers Multiple plant plants RDR RDRα RDRα type RDRγ recent finding recent findings recombinant inbred lines recombination event Region related resistance resistance gene resistance genes resistance mechanism RNA RNA–dependent RNA polymerase shown Solanum chilense Solanum chilense –derived Ty-1 and Ty-3 genes specificity subtropical susceptible these viruses Tobacco Tobacco Rattle Virus tomato Tomato yellow leaf curl virus Tomato Yellow Leaf Curl Virus Disease transcriptional tropical Ty-1 Ty-1 and Ty-3 Ty-1/Ty-3 gene Ty-3 TYLCV virus Virus Disease viruses yellow [DOI] 10.1371/journal.pgen.1003399 PMC 바로가기 [Article Type] Research Article