PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19PIKfyve 특정 억제제는 시험관 내에서 여러 코로나바이러스의 복제를 제한하지만 COVID-19의 쥐 모델에서는 제한하지 않습니다Article Published on 2022-08-122022-09-11 Journal: Communications Biology [Category] 비임상, 임상, 치료기술, 치료법, 치료제, [키워드] antiviral activity apilimod approved authorization cell line claimed Community Compound COVID-19 COVID-19 pandemic disease Efficacy effort Emergency Emergency use authorization Healthcare systems human coronaviruses in vitro inhibitor Medical countermeasures multiple coronaviruses murine model nucleoside pandemic Paxlovid phase PIKfyve PIKfyve inhibitor prophylactically Protease inhibitor Remdesivir Replication Research restrict small molecule tested the United State therapeutic Therapeutics these compound these compounds Treatment Trial trials United States Vaccine writing [DOI] 10.1038/s42003-022-03766-2 PMC 바로가기 [Article Type] Article
SARS-CoV-2 pre-exposure prophylaxis: A potential COVID-19 preventive strategy for high-risk populations, including healthcare workers, immunodeficient individuals, and poor vaccine respondersSARS-CoV-2 노출 전 예방: 의료 종사자, 면역 결핍 개인, 백신 반응 불량자를 포함한 고위험 인구를 위한 잠재적인 COVID-19 예방 전략Review Published on 2022-08-082022-09-11 Journal: Frontiers in Public Health [Category] SARS, 변종, 치료제, [키워드] addition administration anti-SARS-CoV-2 Antibody titer Antiviral antiviral drugs benefit building complementary contributing to COVID-19 COVID-19 patient COVID-19 vaccine COVID-19 vaccines creating drug drug combination drugs effective framework Health care health care systems healthcare Healthcare workers high-risk population HIV HIV disease individuals Infection knowledge limit molnupiravir new virus Nirmatrelvir outcomes pandemic Paxlovid populations pre-exposure prophylaxis (PrEP) PrEP Prevent progression Prophylaxis Protective Protective antibody Remdesivir remdesivir. Responder responders restrict risk factor Risk factors Ritonavir SARS-CoV-2 SARS-COV-2 infection secondary to severe COVID-19 severity shown Spread suppressed Transmission uninfected Vaccine variants widespread [DOI] 10.3389/fpubh.2022.945448 PMC 바로가기 [Article Type] Review
Psychological and financial impacts of COVID-19-related travel measures: An international cross-sectional studyCOVID-19 관련 여행 조치의 심리적 및 재정적 영향: 국제 횡단 연구Article Published on 2022-08-052022-09-11 Journal: PLoS ONE [Category] SARS, 변종, [키워드] affected Anxiety children Chronic illness collected data Community COVID-19 cross cross-sectional Depression employment essential worker evaluate Factor female Financial status Formula Health help highlight identify Impact individuals International movement Older populations provided Psychological psychological health psychologically reported responses restrict separated severe depression severity Stress stress level stress levels text Travel variant [DOI] 10.1371/journal.pone.0271894 PMC 바로가기 [Article Type] Article
Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial Research Published on 2022-08-012022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, [키워드] antibodies approved biopsy blockade Blood BRAF carried circulating clinical trial Colorectal cancer disease DNA Efficacy EGFR eight Endpoint enrolled EudraCT growth factor monoclonal antibody mutant alleles Mutation Open-label Patient patients primary endpoint randomized trial RAS receptor regimen responses restrict secondary single-arm phase 2 Standard-of-care subsequent survival therapy Tolerability Treatment Trial Tumor were excluded wild-type Withdrawal [DOI] 10.1038/s41591-022-01886-0 [Article Type] Research
Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins25-하이드록시콜레스테롤의 항바이러스 분자 메커니즘 연구: 콜레스테롤 항상성 교란 및 단백질의 번역 후 변형Review Published on 2022-07-052022-09-11 Journal: European journal of pharmacology [Category] 치료제, [키워드] 25-Hydroxycholesterol activating Antiviral antiviral activity antiviral drug antiviral drugs Antiviral mechanism binding catalyzed cholesterol cholesterol homeostasis contribute coronavirus disease Coronavirus disease 2019 Efficiency efficient endoglycosidase endosomal pathway global public health glycan glycans glycosylation hydroxylase impair in vitro in vivo inhibiting Innate immunity Lipid Lipid raft liver Maturity mechanisms Modification molecular mechanism nucleic acid outbreak oxysterol oxysterol-binding protein pathway post-translational modification Post-translational modification. prenylation Previous studies previous study Protein reactive receptor reduce restrict second sensitivity shown Sterol Toxicity Viral protein Viral proteins virus [DOI] 10.1016/j.ejphar.2022.175033 PMC 바로가기 [Article Type] Review
Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections세린 프로테아제 억제제는 SARS-CoV-2 감염에 대한 숙주 감수성을 제한합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] A1AT acute respiratory syndrome Administered Affect affecting age Alpha alpha-1-antitrypsin antithrombin III antitrypsin Antiviral antiviral drug antiviral intervention approach asymptomatic infection asymptomatic infections ATIII can be used cellular cellular protease ciliated cleavage club Comorbidities Comorbidity complex coronavirus disease Coronavirus disease 2019 COVID-19 deficiency determinant determinants disease disease severity Donor door expression expression level Factor Genetic Genetic variation Genetic variations goblet cells highlight Host human donors identification identify identity immune response individual Infection inhibitor inhibitors less lung cell mechanism mechanism of action outcome PAI1 Patient patients plasminogen activator inhibitor 1 Potential potential treatments primary cell primary cells reduce reducing regulate restrict risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility Serine serine protease serine protease inhibitor serine protease inhibitors serpin serpin. SERPINA1 SERPINE1 SERPINE2 serpins Severe acute respiratory syndrome severe COVID-19 severe infections Sex Single-cell RNA sequencing Spike protein susceptibility susceptible Symptom target cells TMPRSS2 Treatment Usage Variation viral burden viral entry viral spike protein [DOI] 10.1128/mbio.00892-22 PMC 바로가기 [Article Type] Article
The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9bDeubiquitinase USP29는 ORF9b의 프로테아좀 분해를 방지하여 SARS-CoV-2 독성을 촉진합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Antiviral biological processes canonical carboxyl caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense Degradation deubiquitinase deubiquitination. develop E3 ubiquitin ligase E3 ubiquitin ligases effort eGFP enhancement Evidence Health healthy help Host host defense hosts IFN IFN-I IKKɑ Immunity inhibit inhibiting innate immune response Intensive interact Interaction IκB mechanisms Modification mRNA level NF-κB NF-κB activation Orf9b Particles pathogen pathogenicity pathway Prevent Preventing proliferation proteasomal proteasome Protein regulate Regulation Replication replication-competent SARS-CoV-2 restrict resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Signaling subsequent Transcription Type I IFN type I interferon ubiquitin USP29 viral infections virulence [DOI] 10.1128/mbio.01300-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5SARS-CoV-2 ORF7a는 숙주 인자 SERINC5의 항바이러스 효과를 강력하게 억제합니다Article Published on 2022-05-262022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome coronavirus Antiviral effect biogenesis Cell fusion cellular coronavirus 2 counteract evaluated expressed Factor HIV Host Human Human immunodeficiency virus immunodeficiency virus incorporation information inhibit involved ORF7a Protein respiratory restrict retroviruses SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SERINC5 Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sphingolipid transmembrane protein turn virion virions virus infectivity while [DOI] 10.1038/s41467-022-30609-9 PMC 바로가기 [Article Type] Article
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2 Research Published on 2022-05-162022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition Antiviral Antiviral compound antiviral drug B.1.1.529 characterization chimeric COVID-19 delta variant dominant effective Effectiveness evaluated expressing hamster hamsters individual isolate less Lineage mice molnupiravir monoclonal antibody Mutation Neutralizing activity omicron organ pathogenicity plasma raised recipient reduction in REGN10933 REGN10987 Replication replicative restrict rodent S309 SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains Strains susceptibility the spike protein therapeutic Vaccine Vaccines variant variants viral infection [DOI] 10.1038/s41586-022-04856-1 [Article Type] Research
Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screenCRISPR/Cas9 화면을 통한 SARS-CoV-2의 제한 요인으로 DAXX 식별Article Published on 2022-05-042022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antiviral activity basal Cell culture CRISPR cytoplasmic DAXX Degradation dependent on DNA virus DNA viruses domain expression Factors functional human cells identification identify independent independent of Infection inhibitor interferon life cycle limit Localization mechanism nuclear over-expression Papain-like protease pathway PLPro PML promote proteasome Protein Replication replication of SARS-CoV-2 restrict restriction factor retroviruses SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle SARS-CoV-2 replication scaffold protein the SARS-CoV-2 Trigger turn [DOI] 10.1038/s41467-022-30134-9 PMC 바로가기 [Article Type] Article