A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of ConcernRBD 및 S2를 표적으로 하는 이중특이성 항체는 SARS-CoV-2 오미크론 및 우려되는 기타 변이체를 잠재적으로 중화합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta binding bispecific antibodies breadth Breakthrough infection caused concern contagious coronavirus country COVID-19 COVID-19 vaccines Delta demonstrated domain dominant effective Efficacy epitope Epitopes feasible highlighting IMPROVE mAbs monoclonal antibody Mutation neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibodies. neutralizing antibody omicron Omicron variant Omicron variants Other other variant other variants parental Prevent Pseudotyped virus RBD Receptor-binding domain reduced respiratory retained SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 WT specificity Spike protein target targeting tested the spike protein therapeutic treat Vaccine variant variants variants of concern VoC VOCs wild-type [DOI] 10.1128/jvi.00775-22 PMC 바로가기 [Article Type] Article
Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2 Research Published on 2022-08-182022-10-05 Journal: Nature Medicine [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Administered administration Antiviral applicability approach conserved Critical disease drugs genetic change Genome greater hamster highlight IAV identify Immunity implication in vitro in vivo influenza A virus isolates mice Mutation nucleic acid predicted Prophylactic Prophylaxis provided retained RNA RNA secondary structure RNA structure SARS-CoV-2 secondary structure survival the SARS-CoV-2 therapeutic targeting therapy Transmission Vaccine variant viral genome Viral RNA virus [DOI] 10.1038/s41591-022-01908-x [Article Type] Research
Calpains in cyanobacteria and the origin of calpains Research Published on 2022-08-162022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Anabaena analyses Analysis archaeal Bacteria Bacterial calpain cellular processes cleavage Clusters cysteine protease defined domain Donor enzyme eukaryote eukaryotes eukaryotic explain Human in silico independent information Interaction interaction partner investigated involved mammals Modification Phylogenetic analysis predicted Protein responsible retained selected substrates variety [DOI] 10.1038/s41598-022-18228-2 [Article Type] Research
Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariantsArticle Published on 2022-08-082022-10-06 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acting acute respiratory syndrome Administered administration antibody approved B.1.1.529 breadth cell line cGMP characterized coronavirus COVID-19 CRIPT DARPA defined diagnosed domains Emergency use FDA H2L2 mice Harbor human clinical trials human IgG1 intranasal intranasally intravenous intravenously K18-hACE2 transgenic mice LALA limit lineages Live virus lung titer NAb neutralization assays Neutralizing Neutralizing activity neutralizing antibody omicron Omicron BA.1 Omicron BA.1.1 Omicron BA.2 Pre-clinical research provided pseudotype quantitation reduced required retained SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike subset tested therapeutic Therapies treat vaccination variant variants of concern variants of concern. virus weight loss [DOI] 10.1016/j.medj.2022.08.002 PMC 바로가기 [Article Type] Article
Consensus recommendations for opioid agonist treatment following the introduction of emergency clinical guidelines in Ireland during the COVID-19 pandemic: A national Delphi studyResearch article Published on 2022-08-012022-10-05 Journal: The International Journal on Drug Policy [Category] 치료법, [키워드] Addiction services Care change clinical clinical guideline Clinical guidelines Community Consensus COVID-19 DelPhi Delphi technique develop domains dosage doses drug policy Emergency Final for inclusion Frequency Guidance guideline harm reduction Health identify include introduced involved Ireland lower quartile maintenance phase median methodology National OAT Opioid agonist treatment over pandemic practitioners promote provided psychiatrists reached recommendation recruited Result resulting retained risk Safe Substance use disorder Treatment Urine [DOI] 10.1016/j.drugpo.2022.103768 [Article Type] Research article
Case report: Variant-specific pre-exposure prophylaxis of SARS-CoV-2 infection in multiple sclerosis patients lacking vaccination responses증례 보고: 백신 접종 반응이 없는 다발성 경화증 환자에서 SARS-CoV-2 감염의 변종 특이적 노출 전 예방Case Reports Published on 2022-07-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-CD20 treatment antibody cocktail approved Asymptomatic Case report Case series case sery Casirivimab cilgavimab conducted coronavirus coronavirus disease coronavirus disease (COVID-19) COVID-19 infection develop dose European Evidence evidence of FIVE humoral Imdevimab immunomodulatory Immunotherapy impair incidence Infection Initially monoclonal monoclonal antibody multiple sclerosis Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody offered omicron Omicron variant one patient pandemic Patient patients positive RT-PCR predominant prophylactic treatment Prophylaxis receptor reduced respiratory respiratory tract infection response retained Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe adverse event severe adverse events Sotrovimab specific antibodies sphingosine sphingosine-1-phosphate sphingosine-1-receptor modulators (S1PR) sustained Symptom T-cell T-cells the patient the SARS-CoV-2 Tixagevimab Treatment union upper respiratory tract upper respiratory tract infection vaccination vaccination response vaccination. variant were recorded [DOI] 10.3389/fimmu.2022.897748 PMC 바로가기 [Article Type] Case Reports
Pre-Omicron Vaccine Breakthrough Infection Induces Superior Cross-Neutralization against SARS-CoV-2 Omicron BA.1 Compared to Infection AlonePre-Omicron 백신의 획기적인 감염은 단독 감염에 비해 SARS-CoV-2 Omicron BA.1에 대해 우수한 교차 중화를 유도합니다Article Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] antibody antibody levels Antibody Response Antibody responses B.1 boost Breakthrough infection comparable convalescent convalescent sera convalescent serum correlated COVID-19 patient cross-neutralization cross-neutralizing antibodies cross-neutralizing antibody Delta disease elicited evade form Gamma had no higher affinity highlight Immunity individuals induce infecting Infection Live virus Mild moderate disease N-terminal domain neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity NTD nucleocapsid omicron Omicron BA.1 Patient patients with moderate Protein Proteins raise RBD Receptor-binding domain remained retained SARS-CoV-2 SARS-CoV-2 variants sera spike Spike protein Spike proteins strain Strains Superior the disease the RBD the receptor-binding domain the Spike the spike protein Transmissibility vaccination Vaccine Variability variant variants variants of concern variants of concern (VOCs). virus-induced antibodies VoC VOCs [DOI] 10.3390/ijms23147675 PMC 바로가기 [Article Type] Article
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strainsSARS-CoV-2 Omicron 계통 균주에 의한 감염에 대한 S309 및 AZD7442 단일클론 항체 치료의 회복력Article Published on 2022-07-022022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acting Antibody neutralization AstraZeneca Cell culture changes in Combination correlation analyses Correlation analysis Effect Efficacy Express FcγR hACE2 human ACE2 humans in vitro In vitro studies in vitro study in vivo Infection Interaction K18-hACE2 Lineage Lung infection mAb mechanism mice monoclonal antibody monoclonal antibody therapies monoclonal antibody treatment monotherapy neutralization neutralization potency Neutralizing activity omicron Omicron variant Omicron variants Prevent Prophylactic Protective reduced reductions reductions in Resilience retained S309 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 variant Spike protein strain suggested susceptible the spike protein therapeutic therapy transgenic mice treat Treatment variant variants Viral viral burden [DOI] 10.1038/s41467-022-31615-7 PMC 바로가기 [Article Type] Article
Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing단일 세포 RNA 시퀀싱으로 밝혀진 COVID-19 회복기 개인의 면역 기능Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation addition B cell B cell subset B cells Bioinformatics analysis biological processe biological processes CD4 CD8 Cell cell receptor cell-cell adhesion clonal expansions Cluster convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent individual convalescent individuals convalescent patient Convalescent patients COVID-19 Critical declined decreased expression differentiation downregulation effector memory feature function functions GNLY HLA class I HLA class II HLA class II genes humoral immune response Humoral immunity immune protection immune response immune responses increased expression infections Innate innate immune responses Innate immunity Interferon-gamma involved leukocyte mapped marginal zone mechanism Migration moderate natural infection neutrophil Peripheral blood peripheral blood samples phenotypic reflected Regulation Reinfection retained RNA SARS-CoV-2 SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses severe cases single cell RNA sequencing Single-cell RNA sequencing subjects subset sustained T cell T cell activation T cell response T/B cell receptor repertoire. TCR upregulation was increased weakened with COVID-19 zone [DOI] 10.1016/j.intimp.2022.108767 PMC 바로가기 [Article Type] Article
In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19 Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료법, 치료제, [키워드] Acidic analysis Analysis antiviral activity aromatic group average binding affinities binding affinity binding free energy binding interaction Ceftazidime Cell Compound coronavirus COVID-19 demonstrated docking exceptional exhibited FIVE fraction functional greater groups Health high stability HPLC Hydrogen bond in silico in vitro study Interaction less lowest MD simulation Molecular dynamics simulation occurred oxygen pandemic penetration Potential treatment predict Protein RBD RBD residue Receptor binding domain required retained SARS-CoV-2 SARS-CoV-2 viral selected similarity suggested the RBD the SARS-CoV-2 these compound Toxicity Treatment [DOI] 10.1038/s41598-022-15288-2 [Article Type] Research