Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2SARS-CoV-2 S 단백질을 발현하는 폭스바이러스 MVA는 강력한 면역을 유도하고 SARS-CoV-2로부터 붉은털원숭이를 보호합니다Article Published on 2022-03-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] BAL Bronchoalveolar lavage caused Cell clinical trials Computed tomography COVID-19 COVID-19 pandemic cytokine Cytokine storm domain effective vaccine Effective vaccines Efficacy elicited expressing favor Fever full-length SARS-CoV-2 histological histological examination IFNγ IgG antibodies IgG antibody IL-4 immunogenic immunogenicity lung Lung pathology Lungs macaque macaques modified vaccinia virus MVA vaccine nasal mucosa Neutralizing antibodies neutralizing antibody novel Protein Receptor-binding domain reduced reduction rhesus rhesus macaque rhesus macaques robust Safe Safety SARS-CoV-2 SARS-CoV-2 S several variant several variants Spike. tomography vaccination Vaccine virus load [DOI] 10.3389/fimmu.2022.845887 PMC 바로가기 [Article Type] Article
Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBDArticle Published on 2022-02-152022-10-04 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] ACE2 acute respiratory syndrome affinity antibody Autoimmunity Beta binding epitope characterized Contact coronavirus Cryoelectron microscopy Delta eliminated enzyme Epidemic epitope experiment globe high affinity highlight hydrophobic in vitro inhibitory concentration Interaction Microscopy monoclonal antibody Mutation neutralization neutralize neutralized overlap RBD Receptor binding domain rhesus SARS-CoV-2 SARS-CoV-2 variant Spike protein Spike proteins therapeutic therapeutic efficacy therapy Tolerance transgenic mice Transmissibility Vaccine variants of concern viral burden VoC VOCs [DOI] 10.1038/s41421-022-00381-7 PMC 바로가기 [Article Type] Article
Subcutaneous remdesivir administration prevents interstitial pneumonia in rhesus macaques inoculated with SARS-CoV-2렘데시비르 피하 투여로 SARS-CoV-2 접종한 붉은털원숭이의 간질성 폐렴 예방Article Published on 2022-02-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] absence administer administration animal animal model Antiviral caused COVID-19 COVID-19 patient COVID-19. disease Efficacy hospitalized patients in vivo inoculated interstitial pneumonia intravenously Lower respiratory tract lower respiratory tract disease macaque macaques post inoculation Prevent PROTECT reduced reduction Remdesivir Respiratory disease rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection Subcutaneous subcutaneous administration tested treated Treatment utility virus virus replication [DOI] 10.1016/j.antiviral.2022.105246 PMC 바로가기 [Article Type] Article
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2 감염 중 면역 역학의 연령 관련 차이Research Article Published on 2022-01-172022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] advanced age age aging Analysis animal animals Antiviral Bronchoalveolar lavage fluid Cellular immune response cellular immune responses clinical observations Clinical signs cohorts cytokine cytokine level cytokine levels difference disease eight evaluated exhibited flow cytometry immune Immune homeostasis immune response immune responses immunohistochemistry impair Increased inflammation-associated gene inflammation-associated genes Inflammatory Innate immune defense innate immune defenses inoculated lipid mediator Local macaque mediator multiplex Older outcomes pro-inflammatory response pulmonary infiltrates responses return rhesus rhesus macaque rhesus macaques risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 single-cell Single-cell transcriptomics sustained T-cell Response T-cell responses Thoracic transcriptomics various tissues Viral viral RNA quantification virus replication [DOI] 10.26508/lsa.202101314 PMC 바로가기 [Article Type] Research Article
Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus MacaquesImmunology Published on 2021-12-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] anatomical anatomical compartment anti-spike monoclonal antibody antibodies antibody probes COVID-19 CR3022 demonstrated development fluorescent Frequency identify in vivo infected cell lung macaque macaques nonhuman primates Novel coronavirus pathology Pneumonia probe question Replication respiratory symptom rhesus rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection spatiotemporal tissue block track viral spread virus [DOI] 10.3389/fimmu.2021.810047 PMC 바로가기 [Article Type] Immunology
COVID-19 and gut immunomodulation코로나19와 장 면역 조절Review Published on 2021-12-142022-09-12 Journal: World journal of gastroenterology [Category] SARS, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition angiotensin-converting enzyme-2 antibodies association calprotectin changes in clinically Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Cytokines dependent on direct infection disease disease severity Dysbiosis epithelial cell expresse Gastrointestinal gastrointestinal symptoms GI symptom GI symptoms GI Tract Gut gut microbiota Health heterogeneous hypoxia immune immune activation immune response Immunity immunoglobulin A impairment in vitro in vivo infect infected individual Infection Innate innate immune response intestinal epithelium observation organ organoids outcome Pathogenesis Patient positive Pre-existing diseases Probiotic Proinflammatory cytokine protease Protein reported required respiratory problems respiratory symptom Respiratory system rhesus SARS-CoV-2 serine 2 severe COVID-19 patient severe respiratory illness severity Stool supported Symptom symptomatic patient the disease therapeutic interventions Therapeutics Therapeutics. transmembrane Viral RNA virus [DOI] 10.3748/wjg.v27.i46.7925 PMC 바로가기 [Article Type] Review
Waning antibodies from inactivated SARS-CoV-2 vaccination offer protection against infection without antibody-enhanced immunopathology in rhesus macaque pneumonia models비활성화된 SARS-CoV-2 백신 접종으로 인한 항체 약화는 붉은털 원숭이 폐렴 모델에서 항체 강화 면역병리학 없이 감염에 대한 보호를 제공합니다Letter Published on 2021-11-212022-09-10 Journal: Emerging Microbes & Infections [Category] Coronavirus, SARS, 진단, 치료기술, [키워드] absence acute phase acute respiratory syndrome acute respiratory syndrome coronavirus ADE alveolar anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody Response Antibody-dependent enhancement bronchioles Bronchoalveolar lavage Bronchoalveolar lavage fluid Cell cellular immunity clinical trial control group coronavirus Coronaviruses elevated epithelial Evidence evidence of humans IL-33 IL-8 immunology immunopathology inactivated Inactivated Vaccines Infection initial MCP-1 MERS-CoV Middle East Middle East respiratory syndrome Coronavirus Mild mild to moderate moderate Mucus murine neutralizing antibody NHP no evidence of observation offer passive transfer Pneumonia polyclonal antibodies polyclonal antibody postvaccination preclinical studies preclinical study pulmonary immunopathology reported respiratory Respiratory disease respiratory diseases respiratory syndrome coronavirus rhesus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus subneutralizing antibodies supported transfer Typical vaccination Vaccine virus virus infection [DOI] 10.1080/22221751.2021.2002670 PMC 바로가기 [Article Type] Letter
Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies2개의 비경구 투여 SARS-CoV-2 중화 항체의 조합을 사용하여 붉은털 원숭이에서 COVID-19의 효과적인 예방Cellular and Infection Microbiology Published on 2021-11-182022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, [키워드] accelerate added Administered administration anti-SARS-CoV-2 antibody combination benefit beta coronavirus block blocking clinical study Cohort Combination combination treatment Complete COVID-19 disease dose effective evidenced immunoprophylaxis Infection lack lower dose mAb macaque monoclonal antibody mucosal neutralize nonhuman primates parenteral administration pathogenic pathologic pathology pharmacokinetics prophylactically Protective receiving Result rhesus SARS-CoV-2 SARS-CoV-2 antibodies subset swabs tissue viral challenge viral infection virus Virus neutralization worldwide pandemic [DOI] 10.3389/fcimb.2021.753444 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaquesResearch Article Published on 2021-10-222022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] absence animal B.1 B.1.1.7 B.1.351 bronchoalveolar can be used caused changes in chemokine circulation clinical disease confounding factors cytokine D614G description Efficacy favor immune evasion inoculated inoculation less lung lung lesions Medical countermeasures nasal samples pathogenicity phenotypical Replication respiratory tract rhesus rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 variant severe disease Transmissibility up-regulated variants of concern virus titers VoC [DOI] 10.1126/sciadv.abj3627 PMC 바로가기 [Article Type] Research Article
Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model피내 전달 DNA 백신은 붉은털 원숭이 SARS-CoV-2 챌린지 모델에서 바이러스 부하 감소를 매개하는 내구성 면역을 유도합니다Article Published on 2021-09-282022-09-12 Journal: Cell Reports Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] Abstract adaptive immune system ADCD ADCP anti-SARS-CoV-2 Antigen Arm caused cellular challenge clinical trials clinically coronavirus Coronavirus disease 2019 COVID-19 COVID-19 disease DNA vaccine Efficacy Electroporation evaluated humoral humoral immune response ID DNA vaccine immune immune response Immunity immunization induce Infectious disease INO-4800 lung macaque neutralized neutralizing antibody responses protection Protective pseudotype viruses public health RBD binding antibody recall reduced viral load reduction in regimen respond response resulting rhesus rhesus macaque SARS-CoV-2 SARS-CoV-2 spike Spike protein Support the SARS-CoV-2 the SARS-CoV-2 virus vaccination vaccine dose Viral load [DOI] 10.1016/j.xcrm.2021.100420 PMC 바로가기 [Article Type] Article