Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection혈장 프로테옴 지문은 SARS-COV-2 감염의 고유성과 임상 결과를 나타냅니다.Observational Study Published on 2021-12-072022-08-31 Journal: Viruses [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] ADM Analysis analyzed assist AUROC cardiovascular disease circulating clinical Clinical management Clinical outcome Comparative Course COVID-19 death determine diagnostics disease emergency department emergency medicine evaluated fatality fingerprint helping Hospital admission Hospitalization hospitalized patient IL-6 Infection Inflammation intensive care Kinetics MCP-3 pathophysiology Patient PD-L1 plasma plasma protein plasma proteins plasma samples Predictive presenting Protein proteome proteomic proteomics proximity extension assay risk prediction SARS-CoV-2 SARS-COV-2 infection Standard of care stratified subsequent supported symptoms of COVID-19 TRAIL translate [DOI] 10.3390/v13122456 PMC 바로가기 [Article Type] Observational Study
Algorithm for Individual Prediction of COVID-19–Related Hospitalization Based on Symptoms: Development and Implementation StudyOriginal Paper Published on 2021-11-152022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, SARS, [키워드] 95% CI Accuracy Admission age Ageusia Algorithm Algorithms Anosmia applied assist C-index calibrated Care Clinical data Comorbidities cough COVID-19 COVID-19 hospitalization COVID-19 pandemic COVID-19 patient COVID-19 severity COVID-19 testing data set database dead death develop development diagnosed with COVID-19 diarrhea died digital data discrimination Dyspnea exposure Fever headache Health health records high risk high-risk patient High-risk patients Hospital admission Hospitalization Hospitalized impacted individual Italy management medium monitoring system myalgia objective Odds ratio ordinal logistic regression outcome pandemic Patient patients patients with COVID-19 prediction prediction models Predictive primary care public health Region resource Result risk risk prediction severe outcome Sex Stratification stratified study population Symptom Symptoms vomiting with COVID-19 [DOI] 10.2196/29504 PMC 바로가기 [Article Type] Original Paper
External validation of hepatocellular carcinoma risk scores in patients with chronic hepatitis B virus infection in ChinaArticle Published on 2021-10-012023-06-12 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] CU-HCC hepatitis B Hepatocellular carcinoma modified PAGE-B risk prediction [DOI] 10.1111/jvh.13569
Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19Article Published on 2021-08-302022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI acute respiratory syndrome Admission age association biomarkers of inflammation characterized collected composite endpoint coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRP death determinant dialysis died examined healthy volunteer Hospitalization hospitalized COVID-19 patient In-hospital increase in independent inflammatory biomarkers involved leukocyte Level male mechanical ventilation modulation multivariable analyses OPN osteopontin outcome outcomes Patient patients with COVID-19 PCT predict procalcitonin Prognostic factor renal replacement therapy required risk risk prediction risk-stratify patient RRT SARS-CoV-2 Sepsis serum significantly higher survival utility with COVID-19 [DOI] 10.3390/jcm10173907 PMC 바로가기 [Article Type] Article
Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens3가 MMR 및 Tdap 백신 항원에 의해 유도된 COVID-19의 보호 이종 T 세포 면역Clinical and Translational Article Published on 2021-08-142022-09-14 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 백일해, 임상, 진단, 치료기술, 치료법, [키워드] Abstract Activation acute respiratory syndrome Administered Analysis Anti-viral immunity Antibody titers Antigen antigen presenting cells antigens APC assays autologous CD45RA Cell co-cultured Cohort Context Control coronavirus coronavirus disease correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccination cross-reactive death disease severity Donor driving Effect effective effector memory elicit ELISA ELISPOT ENhance enzyme-linked immunospot epitope feature Features finding flow cytometry foundation funding Heterologous heterologous immunity IFN-γ IL-15 Immunity implicated individual individuals Infection interferon-γ investigated memory memory T cells microbe mitigate MMR nucleocapsid outcomes overlapping Participants Pathogens phenotype promote PROTECT Protective Protein Reactivation recognizing reduced required response risk prediction SARS-CoV-2 SARS-CoV-2 antigen scRNA-seq severe COVID-19 Single-cell RNA sequencing subset supported T cell TCR TCR repertoire transcriptional Transcriptome trivalent uninfected vaccination Vaccine vaccine antigen Vaccines validation study viral infection with mild disease [DOI] 10.1016/j.medj.2021.08.004 PMC 바로가기 [Article Type] Clinical and Translational Article
Identifying patients with symptoms suspicious for COVID-19 at elevated risk of adverse events: The COVAS scoreMulticenter Study Published on 2021-08-012023-07-12 Journal: The American journal of emergency medicine [Category] SARS, [키워드] COVID-19 emergency medicine risk prediction SARS-CoV-2 [DOI] 10.1016/j.ajem.2020.10.068 PMC 바로가기 [Article Type] Multicenter Study
Development and validation of a clinical and genetic model for predicting risk of severe COVID-19심각한 COVID-19의 위험을 예측하기 위한 임상 및 유전 모델의 개발 및 검증Original Paper Published on 2021-07-022022-09-11 Journal: Epidemiology and Infection [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval calibration characteristic clinical coronavirus disease Coronavirus disease 2019 COVID-19 dataset development dispersion Effect Evidence evidence of genetic model genetic risk factor Infection transmission knowledge log Logistic regression magnitude multivariable logistic regression no evidence of Odds ratio participant positive predict receiver receiver operating characteristic Region respiratory risk Risk factors risk prediction SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 severe coronavirus disease severe COVID-19 single-nucleotide polymorphism training dataset UK biobank vaccination Vaccine [DOI] 10.1017/S095026882100145X PMC 바로가기 [Article Type] Original Paper
Haematological inflammatory prognostication in COVID-19: Points to ponder!Comment Published on 2021-07-012023-07-12 Journal: The American journal of emergency medicine [Category] SARS, [키워드] COVID-19 Haematological prognostication Inflammation Neutrophil-to-lymphocyte ratio risk prediction systemic immune-inflammation index [DOI] 10.1016/j.ajem.2020.12.070 PMC 바로가기 [Article Type] Comment
Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls—A Prospective Cohort StudyArticle Published on 2021-06-172022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI acute respiratory syndrome Admission age baseline characteristics Characteristics clinical comparable comparison Control control group controls coronavirus coronavirus disease COVID-19 death Direct enrolled ICU intensive care lactate dehydrogenase MOST outcome oxygen saturation Patient positive prediction predictor presenting prognostic Prospective Protein respiratory infection risk risk prediction SARS-CoV-2 significantly higher tested utility with COVID-19 [DOI] 10.3390/jcm10122672 PMC 바로가기 [Article Type] Article
Development of An Individualized Risk Prediction Model for COVID-19 Using Electronic Health Record DataBig Data Published on 2021-06-042022-10-31 Journal: Frontiers in Big Data [Category] COVID-19, [키워드] abnormality approach Biology calculated calculator Chest chronic condition Cohort cough COVID-19 COVID-19 diagnosis COVID-19 infection CREDIT credit scorecard model Critical depressive Developing development disorder Effect effort EHR EHR data Electronic health record enrolled evaluated feature generate higher risk hospital resources ICD-10 include informatics medical condition Model organ systems Pain Patient positive predict prediction Predictive questionnaire Record Repository resources respiratory symptom risk risk prediction risk score Symptom System tested the timing university [DOI] 10.3389/fdata.2021.675882 PMC 바로가기 [Article Type] Big Data