Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteasesSARS-CoV-2 주요 및 뎅기 바이러스 프로테아제에 대한 강력한 벤족사보롤 억제제의 발견Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral agent Antiviral agents biochemical assay Cell Cell culture class contribute cytotoxicity demonstrated Dengue dengue virus DENV-2 Drug development evaluated had no Health inhibit inhibitor M pro membrane MOST penetration protease Proteases Replication RNA virus RNA viruses SARS-CoV-2 stability synthesis target targets [DOI] 10.1016/j.ejmech.2022.114585 PMC 바로가기 [Article Type] Article
Exploitation of N-Gene of SARS-CoV-2 to Develop a New Rapid Assay by ASOs@AuNPsArticle Published on 2022-10-042022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amplification annealing Antisense oligonucleotide AuNP denaturation detect Detection limit DNA Gold nanoparticle gold standard guanine intensity labeling Modification N-gene New nucleocapsid polymerase chain Rapid Result RNA RNA gene RNA viruses RT-qPCR SARS-CoV-2 simplicity suggested threshold throat swab [DOI] 10.1021/acs.analchem.2c03544 PMC 바로가기
Modeling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent RNA Polymerase by DFT/MM-MD: An Unusual Active Site Leading to High Replication RatesArticle Published on 2022-09-122022-11-15 Journal: Journal of Chemical Information and Modeling [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral assist cellular compensated computation COVID-19 diffusion duplication Efficiency Enzymes highlight histidine Inclusion infecting Infection lack leading less Lower lysine mechanism modeling nucleotide Pandemics performed polymerase polymerases Rate reactive reactivity Replication replication of SARS-CoV-2 RNA RNA genome RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 genome Site subsequent the SARS-CoV-2 viral genome Viral RNA virus [DOI] 10.1021/acs.jcim.2c00802 PMC 바로가기
Antiviral plant-derived natural products to combat RNA viruses: Targets throughout the viral life cycleArticle Published on 2022-09-012022-11-15 Journal: Letters in Applied Microbiology [Category] SARS, 치료제, [키워드] Antiviral antiviral activity Antiviral agents antiviral drug antivirals clinical trial Compound Drug discovery effective Efficacy evaluate in vivo mechanism mechanism of action natural product phytochemical plant plant. Research RNA RNA virus RNA viruses SARS-CoV-2 Stage target therapeutic potential Toxicity viral life cycle virus [DOI] 10.1111/lam.13637 PMC 바로가기
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translationSARS-CoV-2는 mRNA 번역의 NSP2 유도 억제를 통해 인터페론 생산을 손상시킵니다Article Published on 2022-08-092022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 4EHP Antiviral binding cellular cytokine Cytokines Depletion ENhance evade GIGYF2 IFN-β IFNB1 IFNs immunostimulatory impair inhibit innate immune response interact Interaction interferon interferons intrinsic mechanism mRNA mRNA translation mRNA translation. NSP2 Protein RNA viruses SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus significantly suppress target the SARS-CoV-2 the SARS-CoV-2 virus translation type I interferon type I interferons [DOI] 10.1073/pnas.2204539119 PMC 바로가기 [Article Type] Article
Epigenetics may characterize asymptomatic COVID-19 infection후성 유전학은 무증상 COVID-19 감염을 특징지을 수 있습니다Article Published on 2022-07-272022-09-11 Journal: Human Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter Analysis association Asymptomatic Asymptomatic COVID-19 Coronaviruses Course COVID-19 develop diagnosis of COVID-19 DNA methylation enveloped RNA viruses epigenetics had no Illumina Infection limitation Methylation methylation site no symptoms Patient PCR-based testing Peripheral blood peripheral blood samples positive Positive test RNA viruses RT-PCR SARS-CoV-2 Symptom symptomatic infection Symptoms tested with infection [DOI] 10.1186/s40246-022-00401-3 PMC 바로가기 [Article Type] Article
Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy Research Published on 2022-07-252022-10-05 Journal: Communications Chemistry [Category] 바이오마커, 진단, [키워드] Accuracy amino-acid analyzed biochemical Biomarkers Cell contribute COVID-19 Data analysis demonstrated Factor identify infected cell Infection Interaction Microscopy Modification molecular non-infected Raman spectroscopy RNA virus RNA viruses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells significant increase Specific Spread target therapeutic intervention viral pathogenesis virus Virus-host interactions virus-infected cell [DOI] 10.1038/s42004-022-00702-7 [Article Type] Research
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses신종 바이러스에 대해 활성을 나타내는 광범위한 항바이러스제로서 타고난 면역 신호의 인핸서 식별Article Published on 2022-07-212022-09-11 Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 치료제, [키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity boost broad-spectrum antiviral broad-spectrum antivirals Compound coronavirus Defense dependent on Drug screening emerging viruses enhancer Factors Gilteritinib identifying Immunity immunomodulatory molecules immunostimulatory IMPROVE increasingly Infection Innate innate immune innate immune activation Innate immunity innate response interferon interferon regulatory factor interferon regulatory factors. IRF7 IRFs Kinase inhibitor kinase inhibitors library nuclear translocation outbreak Pandemics pathogenic virus pathogenic viruses Pathogens proof proof of concept Regulatory RNA viruses SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus Signaling viral infection virus [DOI] 10.1016/j.chembiol.2022.05.009 PMC 바로가기 [Article Type] Article
Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬Comparative Study Published on 2022-07-082022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic [DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study
Exploring the Chinese Public’s Perception of Omicron Variants on Social Media: LDA-Based Topic Modeling and Sentiment Analysis소셜 미디어에서 오미크론 변종에 대한 중국 대중의 인식 탐색: LDA 기반 주제 모델링 및 감정 분석Article Published on 2022-07-082022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis analyzed Beijing category caused China Chinese Chinese government collected country COVID-19 COVID-19 pandemic Economy FIVE Government Infection knowledge media modeling negative emotions Neutral omicron Omicron variant Omicron variants pandemic Perception positive emotions Prevention and control promote provide Public public health authorities recommendation RNA viruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sentiment analysis Seven Sina Weibo social media Strains Topic topic modeling Vaccine [DOI] 10.3390/ijerph19148377 PMC 바로가기 [Article Type] Article