Development of a thermostable SARS-CoV-2 variant-based bivalent protein vaccine with cross-neutralizing potency against Omicron subvariantsArticle Published on 2022-11-012022-11-15 Journal: Virology [Category] SARS, 변종, 진단, [키워드] Antigen approach Beta Breakthrough infection cross-neutralization cross-neutralizing development Efficacy exhibited mice multivalent Multivalent protein vaccine Neutralizing omicron Omicron subvariants platform Protein risk rodents safety profile SARS-CoV-2 SARS-CoV-2 variant stability thermal thermal stability Vaccine Vaccine hesitancy Vaccines variant variants [DOI] 10.1016/j.virol.2022.09.003 PMC 바로가기
Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats: A short reportArticle Published on 2022-10-262022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] Affect age Brain clinical samples coronavirus determine digital PCR DNA Effect Frequency Future hearts Hypothesis individuals inhibiting kidneys liver majority male mammals mitochondrial Mutation no effect not affect Older patients with moderate Remdesivir RNA-directed RNA polymerases rodents SARS-CoV-2 Skeletal muscle Support therapy tissue treated Treatment Viral RNA [DOI] 10.1371/journal.pone.0271850 PMC 바로가기
Rats and the city: Implications of urbanization on zoonotic disease risk in Southeast AsiaArticle Published on 2022-09-272023-06-22 Journal: Proceedings of the National Academy of Sciences of [Category] 조류인플루엔자, [키워드] land-use change rodents Southeast Asia urbanization zoonotic diseases [DOI] 10.1073/pnas.2112341119 PMC 바로가기
Current status of antihistamine drugs repurposing for infectious diseasesReview article Published on 2022-09-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] active against Anti-infective Antihistamines applicability article Blood brain barrier Candida carried Chemical library clinical trial clinical trials cross current determine dose drug Ebola virus Efficacy English eventual need FIVE Google Scholar Government groups growth Health hepatitis C IC50 identify in vitro activity in vitro data in vivo Infectious disease information inhibited intrinsically lack Leishmania objective off-label Pathogens pharmacological Plasmodium repurposing Research Result rodents Side effects Staphylococcus aureus Staphylococcus epidermidis Support suppressed Trial Trypanosoma virus [DOI] 10.1016/j.medidd.2022.100140 [Article Type] Review article
Genetic diversity of wild rodents and detection of Coxiella burnetii, the causative agent of Q fever, in Saudi ArabiaArticle Published on 2022-09-012023-06-22 Journal: Veterinary Research Communications [Category] 조류인플루엔자, [키워드] Coxiella burnetii Phylogeny Q fever rodents Saudi Arabia wildlife [DOI] 10.1007/s11259-022-09897-5
Fine-scale prevalence and genetic diversity of urban small mammal-borne pathogenic Leptospira in Africa: A spatiotemporal survey within Cotonou, BeninArticle Published on 2022-09-012023-06-22 Journal: Zoonoses and Public Health [Category] 조류인플루엔자, [키워드] health ecology leptospirosis rodents Urban ecology zoonosis [DOI] 10.1111/zph.12953 PMC 바로가기
SARS-CoV-2 surveillance in Norway rats (Rattus norvegicus) from Antwerp sewer system, BelgiumArticle Published on 2022-09-012022-11-15 Journal: Transboundary and emerging diseases [Category] SARS, 변종, 진단, [키워드] activity addition analysed anti-SARS-CoV-2 IgG antibody Antwerp Belgium checked collected COVID-19 epidemic cVNT disease disease outbreaks evaluate Evolution faece human-to-animal transmission humans immunoassay infect infected with SARS-CoV-2 Interpretation Local MIA microsphere Muridae neutralizing antibody Norway oral swabs outbreak positive RATs Rattus reservoir rodents RT-qPCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 surveillance screened sera serological test serum serum sample tested tissue tissue sample variant viral neutralization was tested [DOI] 10.1111/tbed.14219 PMC 바로가기
Cross-reactive immunity against SARS-CoV-2 N protein in Central and West Africa precedes the COVID-19 pandemic중부 및 서부 아프리카의 SARS-CoV-2 N 단백질에 대한 교차 반응성 면역은 COVID-19 전염병보다 앞서 있습니다Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus African antibody anticipated circulation coronavirus COVID-19 pandemic cross-reactive death defense mechanisms Donor Efficacy ELISA Europe examined explain Gabon human immune defense Humoral immunity hypothese Immunity in vitro in vivo indicate investigated involved mechanism mouse model N protein N proteins neutralization neutralize North America nucleocapsid pandemic Population pre-existing immunity presence of antibody prevalent Protective Protein public health respiratory rodent rodents SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N protein SARS-CoV-2 S SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus South specific antibodies specific antibody the N protein Viral viral fitness virus was tested West [DOI] 10.1038/s41598-022-17241-9 PMC 바로가기 [Article Type] Article
Hamster models of COVID-19 pneumonia reviewed: How human can they be?COVID-19 폐렴의 햄스터 모델 검토: 어떻게 인간이 될 수 있습니까?Review Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age alveolar damage animal model characteristic clinically Coagulopathy condition consequence coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 diagnostic Diffuse alveolar damage examined facilitate feature hamster hamsters Histopathology Human human disease humans immune function immune functions Infection Inference Inflammation information limit manifestation Mesocricetus mice moderate molecular outcome pandemic pathology pathway Patient Phodopus Pneumonia Preclinical research Research respiratory respiratory tract review rodents SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity Still susceptible susceptible patient the disease therapy Vaccines variants of concern Vascular virus [DOI] 10.1177/03009858211057197 PMC 바로가기 [Article Type] Review
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655YIns215KLRS 및 H655Y의 비 RBD 돌연변이에 의한 SARS-CoV-2의 N501Y 부여 마우스 감염성의 장거리 향상Article Published on 2022-06-052022-09-11 Journal: Biology Direct [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 Alpha Beta changes in cooperation Cross-species transmission disrupt ENhance facilitate flexible Gamma H655Y high infectiousness hosts Impact impacts increase Ins215KLRS insertion Interaction intramolecular interaction less Local mice mouse Mouse infection mouse-adapted strain mutant Mutation N-terminal domain N501Y N501Y mutation NTD omicron Omicron variants peptide Protein RBD Receptor binding Receptor-binding domain resulting rodents SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike Spike protein suppressed targets the receptor-binding domain variant virus infectivity wild type [DOI] 10.1186/s13062-022-00325-x PMC 바로가기 [Article Type] Article