Protocol for the Metformin Aneurysm Trial (MAT): a placebo-controlled randomised trial testing whether metformin reduces the risk of serious complications of abdominal aortic aneurysm메트포르민 동맥류 시험 프로토콜(MAT): 메트포르민이 복부 대동맥류의 심각한 합병증 위험을 감소시키는지 여부를 테스트하는 위약 대조 무작위 시험Study Protocol Published on 2021-12-272022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] Abdominal aortic aneurysm Alpha Aneurysm aneurysms Antibiotics aortic aneurysm Asymptomatic benefit blood pressure cardiovascular event Cell clinical COVID-19 pandemic defined diabetes double-blind drug therapy event events Evidence evidence of growth include inhibitor International life mast cell medication metformin metformin XR Mortality Multiple observational studies observational study outcome overcome parallel-group participant Patient Placebo placebo-controlled placebo-controlled trial potential participant Primary outcome progression proportion Quality of life randomised randomised controlled trial Randomised trial receive reduce reduced required risk rupture secondary Secondary outcomes serious complication single-blind surgical therapy Trial Trial registration trials unique [DOI] 10.1186/s13063-021-05915-0 PMC 바로가기 [Article Type] Study Protocol
Spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema in non-ventilated COVID-19 patientsResearch Article Published on 2021-11-182022-10-31 Journal: Future Science OA [Category] COVID-19, [키워드] Abstract alveolar analyzed C-reactive protein Chest collected data Complication COVID-19 COVID-19 patient COVID-19 patients emphysema Factor ferritin insertion investigated lactate dehydrogenase less lymphocytopenia mechanical ventilation Most patient obese pathophysiology Patient patients Pneumomediastinum Pneumothorax Respiratory failure rupture Spontaneous pneumothorax subcutaneous emphysema suffered the disease Ventilation [DOI] 10.2144/fsoa-2021-0090 PMC 바로가기 [Article Type] Research Article
A fresh look at coronary microembolization Reviews Published on 2021-11-162022-10-05 Journal: Nature reviews. Cardiology [Category] 바이오마커, [키워드] accompanied acute coronary syndromes antiplatelet atherosclerotic plaque benefit circulation Clinical studies clinical trial contractile contribute Coronary drug dysfunction Endothelial dysfunction facilitate feature incidence increase in induce Inflammatory inflammatory reaction Mechanical mechanism Myocardial Myocardial infarction patchy Percutaneous coronary intervention Perturbation physical review rupture Stress thrombotic Treatment vasoconstriction [DOI] 10.1038/s41569-021-00632-2 [Article Type] Reviews
Partial oral antibiotic treatment for bacterial brain abscess: an open-label randomized non-inferiority trial (ORAL)Randomized Controlled Trial Published on 2021-11-122022-10-04 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 Admission age all-cause mortality Alpha Antibiotic therapy Antibiotic treatment Antibiotics assigned Bacterial blinded Brain Brain abscess caused Cerebral abscess cognitive complications composite endpoint conducted Controlled trial criteria Date Denmark effective Endpoint EudraCT favor Follow-up France Health hospital Immunocompromise include independent International intravenous intraventricular investigator-initiated Netherlands non-inferiority non-inferiority trial Open-label oral outcome parallel group Partial Patient patients Pregnancy primary endpoint Pseudomona Quality of life randomization Randomized Randomized controlled trial recommendation recruitment Registered rupture Sample size scale secondary severe adverse events standard treatment suggested Treatment Tuberculosis [DOI] 10.1186/s13063-021-05783-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis-Associated MechanismsReview Article Published on 2021-10-062022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, [키워드] appear biochemically cell membrane cellular characterized Clinical treatment disparate drug Evidence fatty Ferroptosis form function indicate investigated Lung diseases mechanism membrane molecular molecular mechanism morphologically Necrosis novel organelle Protein regulated Regulated cell death Regulation resulting rupture Strategy targeting therapeutic unsaturated vital role [DOI] 10.1155/2021/1098970 PMC 바로가기 [Article Type] Review Article
COVID-19 Lockdown Increased the Risk of Preterm BirthMedicine Published on 2021-09-272022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 1:1 affected Birth Child China cohort study conducted COVID-19 COVID-19 pandemic enrolled evaluate healthcare higher risk Increased increased risk inverse lockdown maternity membrane non-infected peace pregnant women Premature Premature rupture of membranes Preterm birth Probability propensity score matching PTB retrospective cohort study rupture Shanghai Treatment two groups uninfected very preterm birth Weighting were used women [DOI] 10.3389/fmed.2021.705943 PMC 바로가기 [Article Type] Medicine
Association of ABO and Rh blood groups with obstetric outcomes in SARS-CoV-2 infected pregnancies: A prospective study with a multivariate analysisObservational Study Published on 2021-09-012022-10-05 Journal: European journal of obstetrics, gynecology, and re [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval ABO ABO blood group adjusted odds ratio age Analysis analyzed association Blood Blood Group Cohort collected complications coronavirus COVID-19 difference disease susceptibility distribution Emergency evaluate group groups hemorrhage Hemorrhagic hemorrhagic events lower risk Maternal maternal age Maternal morbidity membrane morbidity mother Neonatal Mortality Obstetric outcome Patient performed pregnancies Pregnancy pregnant women Premature Prospective Prospective Study Rh+ rupture SARS-CoV-2 Spanish Stillbirth symptomatic tested women [DOI] 10.1016/j.ejogrb.2021.07.008 PMC 바로가기 [Article Type] Observational Study
Short-term outcome of pregnant women vaccinated with BNT162b2 mRNA COVID-19 vaccineObservational Study Published on 2021-09-012022-10-05 Journal: Ultrasound in obstetrics & gynecology : the offici [Category] 임상, [키워드] acute respiratory syndrome Administered Admission age arthralgia asked bleeding Blood BNT162b2 mRNA BNT162b2 vaccine calculated case-control study comparable complications control group coronavirus coronavirus disease COVID-19 COVID-19 vaccine death demographics determine dose doses effective evaluate fetal Fever first dose gestation Gynecology headache humoral immune response IgG Immunoglobulin in both group Infection information intensive care interquartile range less Local local pain median medication membrane Neonatal no significant difference Obstetric obstetric outcome offered outcome outcomes participant Patient Pfizer/BioNTech positive Pregnancy pregnant population pregnant women Preterm birth questionnaire Rash reactogenicity recruited Respiratory Support returned rupture SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 IgG second dose second vaccination serology serum serum sample severe fatigue Side effect significantly significantly lower significantly more Society study group study period the study group the vaccine two groups two-dose regimen Ultrasound uterine vaccination Vaccine vaccine dose women [DOI] 10.1002/uog.23729 PMC 바로가기 [Article Type] Observational Study
Unusual Presentation of COVID Pneumonia as Esophageal Rupture Ended With Successful ManagementRadiology Published on 2021-08-212022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abdominal pain accompanied boerhaave's syndrome Care caused causes Chest CT chest pain complex pleural effusion Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) cough coughing COVID COVID-19 COVID-19 pandemic Diagnosis early diagnosis emesis Epidemic esophageal rupture esophagogram Fever gastrointestinal symptoms global pandemic Health iatrogenic implementation incidence increased mortality Infection less Mallory-Weiss syndrome mallory-weiss tear medical resource nausea occur outcome Patient presentation reported Research respiratory symptoms resulting rupture SARS-CoV-2 seeking Sepsis severe respiratory syndrome Shortness of breath surgical Symptoms syndrome the patient transmural Treatment vomiting was performed Wuhan, China [DOI] 10.7759/cureus.17348 PMC 바로가기 [Article Type] Radiology
Clinical Implications of IL-32, IL-34 and IL-37 in Atherosclerosis: Speculative Role in Cardiovascular Manifestations of COVID-19Cardiovascular Medicine Published on 2021-08-062022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] adaptive atherogenesis atherosclerotic atherosclerotic plaque atherosclerotic plaques cardiovascular cardiovascular disease chronic inflammatory disease clinical contribute coronary syndrome COVID-19 COVID-19 cytokine storm CVD cytokine death future therapeutic IL-32 IL-34 IL-37 Immunity implication Infection Inflammation maintain management manifestation Occurrence patients patients with COVID-19 plaque regulated role rupture stability triggering understanding [DOI] 10.3389/fcvm.2021.630767 PMC 바로가기 [Article Type] Cardiovascular Medicine