Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cellsArticle Published on 2022-11-012022-11-15 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 진단, [키워드] 16HBE 16HBE cell 16HBE cells 6-O-angeloylplenolin ACE2 ACE2 expression addition administration Cell Centipeda Centipeda minima chemokine Chinese Compound conducted COVID-19 CX3CL1 CXCL13 dataset demonstrated downregulated entry of SARS-CoV-2 enzyme evaluated expression gene encoding HLF IL-6 inhibited inhibitor Interaction lung epithelial cell Lung epithelial cells lung tissue lung tissues mice modulate parental pathogen phosphorylated positively correlated promoter PROTECT Protein pseudovirus receptor reduced regulate Regulation S protein SARS-CoV-2 SARS-COV-2 infection screened STAT3 STAT3. stimulated suppressed target cells tested TFS Transcription transcription factor transfected with [DOI] 10.1038/s41401-022-00906-6 PMC 바로가기
The mutation features and geographical distributions of the surface glycoprotein (S gene) in SARS-CoV-2 strains: A comparative analysis of the early and current strainsArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] ACE2-binding region acute respiratory syndrome Analysis analyzed coronavirus coronavirus disease COVID-19 COVID-19 vaccines demonstrated develop Evolution feature Frequency Genome genome mutations geographical distribution highest identify loci mutant strain Mutation omicron prevalent remained Result S gene S protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant strain Strains Surface glycoprotein Surface glycoprotein. the receptor-binding domain the S protein The United States United Kingdom Vaccines was used [DOI] 10.1002/jmv.28023 PMC 바로가기
SARS-CoV-2 cell entry beyond the ACE2 receptorArticle Published on 2022-11-012022-11-16 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor AGTR2 ASGR1 Asymptomatic auxiliary B.1.1.529 B.1.1.7 B.1.617.1 B.1.617.2 binding carried CD147 CD26 cell entry cell surface receptors CLEC4G Cochrane Library COVID19 Delta Delta+ develop English enzyme erythrocyte Evidence explain facilitate host cell Hypoxemia Infection KREMEN1 LDLRAD3 membrane protein MeSH term neuropilin omicron organs Protein receptor receptors S protein SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2. SARSCoV-2 selected target therapeutic agent tissue tropism TMEM30A Transmission variants of SARS-CoV-2 viral entry virus entry [DOI] 10.1007/s11033-022-07700-x PMC 바로가기
A Computational Insight on the Inhibitory Potential of 8-Hydroxydihydrosanguinarine (8-HDS), a Pyridone Containing Analog of Sanguinarine, against SARS CoV2Article Published on 2022-11-012023-07-10 Journal: Chemistry & biodiversity [Category] COVID19(2023년), [키워드] 8-hydroxydihydrosanguinarine eugenol molecular dynamics S protein sanguinarine. SARS-CoV2 [DOI] 10.1002/cbdv.202200266 PMC 바로가기
Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cellsArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Alpha Antiviral approved Cell cells cellular cellular response change coronavirus Coronavirus disease-19 COVID-19 cytokine differentially expressed downregulation Effect effort expressing expression highlight homeostasis host cells host response humoral immune responses induce Infection information interferon intrinsic involved medium pandemic pathogenic PROTECT Protein reflected Result S protein SARS-CoV-2 spike Spike protein the S protein transcriptomic transcriptomics transcriptomics. type I Vaccination strategies Vaccine variety while [DOI] 10.3389/fimmu.2022.999233 PMC 바로가기
SARS-CoV-2 variants of concern and spike protein mutational dynamics in a Swedish cohort during 2021, studied by Nanopore sequencingArticle Published on 2022-10-182022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] A222V analysed approach ARTIC Network assist bioinformatics can be used circulating variant Cohort COVID-19 COVID-19 pandemic Delta delta variant distribution genomic Health include less mapped Mutation mutations nanopore sequencing National occurred omicron Patient positive primer Protein public health public health measures Q677H S protein SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant sequence Sequencing sequencing method spike Spike protein Surveillance Swedish the S protein the SARS-CoV-2 the Spike Uppsala County variant variants variants of concern. variants of interest VoC whole-genome sequencing [DOI] 10.1186/s12985-022-01896-x PMC 바로가기
Graphene-Binding Peptide in Fusion with SARS-CoV-2 Antigen for Electrochemical Immunosensor ConstructionArticle Published on 2022-10-172022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody Antibody detection Antibody titers Antigen applied caused characterized conditions construction decrease demonstrated detect diagnosing Diagnosis diagnostic DPV Efficiency electrochemical immunosensor emerging disease Fourier transform fusion Graphene human serum increase in Infection limit of detection Linear regression Microscopy peptide platform positive probe pulse Raman spectroscopy reduced response resulting S protein SARS-CoV-2 SARS-CoV-2 antibodies SBP SEM sera solid-binding peptide (SBP). tested the SARS-CoV-2 the SARS-CoV-2 virus traditional method was performed was used [DOI] 10.3390/bios12100885 PMC 바로가기
Detection of SARS-CoV-2 in a dog with hemorrhagic diarrheaArticle Published on 2022-10-122022-11-15 Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Affect African amino acid substitution analyzed Asymptomatic B.1.177 Bacterial Cell Ceuta characteristic circulation coronavirus COVID-19 detection diarrhea disease dog Dog COVID-19 excluded fecal gastrointestinal tract Genome Hemorrhagic Highland human SARS-CoV-2 human-to-animal transmission Ile402Val S protein substitution Infection Interaction intrinsic knowledge mapped microbial Microbiome MOST negative test Next-generation sequencing NGS North one health pandemic Pathogens pathology positive presenting RBD Receptor binding domain reported RT-PCR test S protein SARS-CoV-2 SARS-CoV-2 genome sequence Sequencing Spain Spanish suffered Terrier the S protein the spike protein USA variant viral loads viral variant virus West zoonosis. [DOI] 10.1186/s12917-022-03453-8 PMC 바로가기
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike proteinArticle Published on 2022-10-042022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome affected Antiviral assays coronavirus coronavirus disease epitope glycoprotein heptad repeat host cell HR2 include inhibit inhibitor interact interfere less membrane membrane fusion Modification monoclonal antibody Mutation N-terminal offer peptide Peptide Inhibitors peptide. peptides performed Protein Receptor binding domain Region related viruses S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Support target the S protein the SARS-CoV-2 the spike protein therapy Vaccine variants viral entry viral membrane viral spike virus infection [DOI] 10.1073/pnas.2210990119 PMC 바로가기