Self-derived peptides from the SARS-CoV-2 spike glycoprotein disrupting shaping and stability of the homotrimer unitSARS-CoV-2 스파이크 당단백질의 자가유래 펩타이드가 동종삼량체 단위의 형태와 안정성을 방해Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] approach binding binding affinity blocker blockers conformation COVID dataset destabilized develop disrupting domain exhibited functional higher affinity homotrimer host cell host cell receptor instability linear Linear motif molecular molecular dynamics monomer motif mutated Mutation opposite peptide peptides Protein protein structure RBD Region regions responsible resulting S protein S1 and S2 S1 and S2 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 S Self-derived peptides shown spike spike glycoprotein stability Structural folding structure-based design subunit Support the S protein the SARS-CoV-2 Vaccine Vaccine design variant wild type β-coronavirus [DOI] 10.1016/j.biopha.2022.113190 PMC 바로가기 [Article Type] Article
Self-reported symptoms and seroprevalence against SARS-CoV-2 in the population of Mato Grosso: a household-based survey in 2020Article Published on 2022-07-012022-11-15 Journal: Revista da Associação Médica Brasileira (1992) [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome antibody applied association Asymptomatic case chemiluminescence Cluster Comorbidities conducted coronavirus coronavirus disease COVID-19 Fever General population Health Hospitalized IgG Immunoglobulin individual no symptoms Older Pain predominant prevalent proportion Protein quantitative determination reported S1 and S2 SARS-CoV-2 SARS-CoV-2 antibody selected self-reported symptom stages Symptom was used [DOI] 10.1590/1806-9282.20220078 PMC 바로가기
Development of a cost-effective ovine antibody-based therapy against SARS-CoV-2 infection and contribution of antibodies specific to the spike subunit proteinsSARS-CoV-2 감염에 대한 비용 효율적인 양 항체 기반 요법의 개발 및 스파이크 소단위 단백질에 대한 항체의 기여Article Published on 2022-07-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affinity antibodies antibody Antibody titre antibody-based therapy Antigen approval approved B.1.1.529 complement complement fixation convalescent plasma COVID-19 demonstrated development evaluated fixation generate highly active Immunoglobulin in vitro Neutralising activity omicron performed phagocytosis plasma polyclonal antibodies polyclonal antibody protective immunity Protein provide raised Regulatory S1 and S2 S2 subunit SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection sheep Spike protein subunit therapy therapy for COVID-19 variant virus was collected widespread [DOI] 10.1016/j.antiviral.2022.105332 PMC 바로가기 [Article Type] Article
Insight towards the effect of the multi basic cleavage site of SARS-CoV-2 spike protein on cellular proteasesArticle Published on 2022-06-062022-11-01 Journal: Virus research [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome Amino acid amino acid substitution Analysis analyzed Antiviral approach binding cathepsin B cell receptor cellular cellular protease cellular proteases cleavage site cleaving coronavirus coronavirus pathogenesis develop domain functional furin furin cleavage site generate Health help Host host cell protease host protease host range incorporation indicated Infection inhibitor insight Interaction involved maturation MD simulation MD simulations molecular molecular docking multi Mutation plasmin polybasic primary determinant protease Protein proteolytic activation Receptor binding S protein S1 and S2 SARS-CoV-2 SARS-CoV-2 spike protein shown spike Spike protein Spread subunits the S protein tissue tropism [DOI] 10.1016/j.virusres.2022.198845 PMC 바로가기 [Article Type] Article
A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virusSARS-CoV-2 변이체에 대해 설계된 보존 소단위 백신은 바이러스를 중화하는 증거를 보여주었습니다Article Published on 2022-06-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition affinity analyzed antibody approach B-cell response conserved coronavirus coronavirus disease country Coverage COVID-19 Cytopathic effect docking domain Efficiency elicit envelope envelope protein epitope Epitope-based vaccine Epitopes Evidence FIVE genomes glycoprotein highest IgG immunogenic immunoinformatics IMPROVE induce linker lung tissue membrane membrane glycoprotein MHC MHC class MHC class I MHC class II mice molecular molecular docking Multi-epitope vaccine Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody novel Novel coronavirus omicron outbreak pandemic peptide peptides Proteins recognize reported required S1 and S2 S2 domain SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequences spike Spike surface glycoprotein, Immunogenic, Neutralizing antibody. Spread step subunit Subunit vaccine Surface glycoprotein surface protein surface proteins T-cell T-cell epitope T-cell epitopes the vaccine Vaccine vaccine construct variant variants variants of SARS-CoV-2 Vero Cell viral surface virus virus replication wild type wild-type virus [DOI] 10.1007/s00253-022-11988-x PMC 바로가기 [Article Type] Article
Relationship between Acute-Phase Symptoms and Immunoglobulin G Seropositivity up to Eight Months after COVID-19COVID-19 이후 최대 8개월까지 급성기 증상과 면역글로불린 G 혈청양성 간의 관계Article Published on 2022-05-262022-09-11 Journal: Medicina [Category] MERS, 진단, 치료제, [키워드] acute phase adjusted analyzed Anosmia antibody Antibody Response Antibody responses chance classification clinical manifestation COVID-19 creating cross-sectional cross-sectional study dependence determinants Dyspnea effective HCW HCWs healthcare worker highest IgG Immunoglobulin Immunoglobulin G knowledge Logistic regression material Month multiple logistic regression Occurrence Odds ratio post-symptom onset proportion relationship responses S1 and S2 serology testing seronegative Seropositivity significantly increased Spike protein Surveillance Symptom symptom onset tested the spike protein was increased [DOI] 10.3390/medicina58060708 PMC 바로가기 [Article Type] Article
Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant델타 스파이크 P681R 돌연변이는 알파 변종보다 SARS-CoV-2 적합성을 향상시킵니다.Article Published on 2022-05-172022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha variant Amino acid cleavage coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CP: Microbiology Delta delta variant ENhance epithelial cell epithelial cells fitness full-length furin furin cleavage site human airway human airway culture human lung human lung epithelial cells IMPROVE Microbiology Mutation P681 P681H P681R pandemic primary human airway reduce reduced Replication S1 and S2 S1/S2 S1/S2 cleavage SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly spike mutation spike P681R subunits tissues variant viral entry virus entry wild-type [DOI] 10.1016/j.celrep.2022.110829 PMC 바로가기 [Article Type] Article
Determinants of Immune Response to Anti-SARS-CoV-2 mRNA Vaccines in Kidney Transplant Recipients: A Prospective Cohort Study신장 이식 수혜자의 Anti-SARS-CoV-2 mRNA 백신에 대한 면역 반응의 결정 요인: 전향적 코호트 연구Article Published on 2022-04-012022-09-12 Journal: Transplantation [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 95% confidence interval acute respiratory syndrome affecting analyzed antibody contrary coronavirus coronavirus disease Cutoff depleting determinant Effectiveness epitope evaluated exhibited Factor humoral immune response independent infected with SARS-CoV-2 interferon gamma kidney transplant recipient mRNA mRNA vaccines mycophenolate Odds ratio Patient Prospective prospective cohort study response S1 and S2 SARS-CoV-2 sensitivity Seroconversion shown significantly more Specific T-cell response specificity Spike protein subset subunit sustained tested the interferon therapy Transplant vaccination Vaccine [DOI] 10.1097/TP.0000000000004044 PMC 바로가기 [Article Type] Article
Antibody Response to SARS-CoV-2 Vaccination in Patients following Allogeneic Hematopoietic Cell Transplantation동종 조혈 세포 이식 후 환자에서 SARS-CoV-2 백신 접종에 대한 항체 반응Article Published on 2022-04-012022-09-11 Journal: Transplantation and cellular therapy [Category] COVID19(2023년), SARS, 치료법, [키워드] age Allogeneic Allogeneic hematopoietic cell transplantation Analysis antibody antibody levels Antibody Response Antibody titer Antibody titers approved BNT162b2 Cell cell transplantation chronic GVHD Cohort conditioning regimen conducted Critical disease domain Efficacy examined Factor Graft-versus-host disease group GVHD had no healthy control healthy controls healthy volunteers hematopoietic Hematopoietic cell transplantation highest homogenous humoral immune response IgA IgG IgM immune response immune responses Immunocompromised patients Immunosuppression information intensity Moderna mRNA mRNA vaccine mRNA vaccines mRNA-1273 nucleocapsid protein pandemic Patient physician reactivity receiving Receptor-binding domain recipient recipients regimen response revaccination S1 and S2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 pandemic SARS-CoV-2 vaccination second dose significantly lower single center spike glycoprotein stratified subunit Switzerland the SARS-CoV-2 the vaccine transplantation Treatment underlying disease vaccination Vaccine waned was performed [DOI] 10.1016/j.jtct.2022.01.019 PMC 바로가기 [Article Type] Article
Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core협력 다가 수용체 결합은 SARS-CoV-2 융합 기계 코어의 노출을 촉진합니다Article Published on 2022-02-222022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding affinity Cell conformational Cooperative coronavirus dissociation domains event induce Interaction membrane fusion molecular molecular dynamics Molecular dynamics simulation Population promote Protein Proteins receptor Receptor binding recognize S1 and S2 S1 and S2 domains S1 domain S1/S2 cleavage SARS-CoV-2 severe acute respiratory syndrome Coronavirus spike spike glycoprotein Spike proteins spike trimer spike trimers the SARS-CoV-2 therapeutic tomography variant virus [DOI] 10.1038/s41467-022-28654-5 PMC 바로가기 [Article Type] Article