In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening [DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article
The use of dried blood spots for the serological evaluation of SARS-CoV-2 antibodiesSARS-CoV-2 항체의 혈청학적 평가를 위한 건조된 혈반의 사용Article Published on 2022-06-272022-09-11 Journal: Journal of public health (Oxford, England) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults alternative antibodies antibody Blood Chain Reaction children cohort study collected coronavirus correlated COVID-19 vaccination detect determine dried blood spot effort ELISA facilitate IgG IgG antibodies IgG antibody IgG level Infectious disease Melbourne Melbourne, Australia Methods participant Participants polymerase chain polymerase chain reaction Population positive public health Public health response Public health responses RBD Receptor-binding domain remained respiratory S1 protein SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2 proteins serological Seropositivity serum serum sample serum samples severe acute respiratory syndrome Coronavirus specimen specimens the receptor-binding domain the SARS-CoV-2 [DOI] 10.1093/pubmed/fdab011 PMC 바로가기 [Article Type] Article
Validation of Serological Methods for COVID-19 and Retrospective Screening of Health Employees and Visitors to the São Paulo University Hospital, BrazilCOVID-19에 대한 혈청학적 방법의 검증 및 브라질 상파울루 대학 병원을 방문하는 의료진 및 방문객에 대한 후향적 검사Article Published on 2022-06-022022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] antigens approach Brazil Clinical studies collected country COVID-19 Critical diagnostic diagnostic test diagnostic tests ECLIA Elecsy Elecsys electrochemiluminescence immunoassay ELISA employee enzyme enzyme-linked immunosorbent assays epidemiological gold gold standard Health health employees house immunoassay in-house ELISA in-house ELISAs infection rates neutralization neutralization test nucleoprotein portion Receptor binding domain Recombinant protein recombinant proteins Roche Diagnostics S1 protein SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 N protein screened Screening screenings sensitivity Sensitivity and specificity serological assays serological test Serological tests serology serum sample serum samples specificity Surveillance the S1 protein the SARS-CoV-2 university university hospital vaccinated individual vaccinated individuals validation virus neutralization test Visitor was used [DOI] 10.3389/fcimb.2022.787411 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and Mitochondrial Proteins in Neural-Derived Exosomes of COVID-19코로나19 신경 유래 엑소좀의 SARS-CoV-2 및 미토콘드리아 단백질Article Published on 2022-06-012022-09-11 Journal: Annals of neurology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료법, [키워드] 12S rRNA acute COVID-19 anion ANN Astrocyte Biomarker Biomarkers calcium calcium channel CD81 Cell Central nervous system Complex I complex III controls COVID-19 Exosome extracellular vesicle Extracellular vesicles Frame healthy controls Human Humanin LETM1 leucine long-COVID manifestation marker MCU mechanism Mitochondria mitochondrial N-methyl-D-aspartate N-methyl-D-aspartate receptor Neuropsychiatric nucleocapsid PASC plasma Protein quantified resolved respiratory chain S1 protein SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 S1 significantly sodium subunit therapeutic therapeutic trials transmembrane trials VDAC1 was used [DOI] 10.1002/ana.26350 PMC 바로가기 [Article Type] Article
Regenerable and high-throughput surface plasmon resonance assay for rapid screening of anti-SARS-CoV-2 antibody in serum samples혈청 샘플에서 항-SARS-CoV-2 항체의 신속한 스크리닝을 위한 재생 가능한 고처리량 표면 플라즈몬 공명 분석Article Published on 2022-05-222022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acid acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition anti-SARS-CoV-2 antibody antibody Antibody test antibody tests association can not channel clinical sample clinical samples Concentration Convalescent patients coronavirus current Detection limit effective ELISA ELISA kit enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay exhibit fluorescent High-throughput histidine mass offer Protein reached reagents reduced reproducibility respiratory S1 protein SARS-CoV-2 SARS-CoV-2 spike sensor serological serological measurement serological measurements serum sample serum samples severe acute respiratory syndrome Coronavirus speed SPR surface plasmon surface plasmon resonance threshold value tris tris-NTA chip. [DOI] 10.1016/j.aca.2022.339830 PMC 바로가기 [Article Type] Article
Fluorescence signatures of SARS-CoV-2 spike S1 proteins and a human ACE-2: excitation-emission maps and fluorescence lifetimesSARS-CoV-2 스파이크 S1 단백질 및 인간 ACE-2의 형광 서명: 여기-방출 지도 및 형광 수명Article Published on 2022-05-012022-09-11 Journal: Journal of Biomedical Optics [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin approach binding change changes coronavirus domain examined excitation excitation-emission maps feature Fluorescence fluorescence decay times human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human angiotensin-converting enzyme 2. identify information involved kinetic knowledge media optical Protein RBD Receptor-binding domain resolved S1 protein S1 subunit SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Specific Spike protein the SARS-CoV-2 were recorded [DOI] 10.1117/1.JBO.27.5.050501 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19)AZD1222(ChAdOx1 nCoV-19) 백신을 접종한 쥐의 시험관 내 SARS-CoV-2 스파이크 단백질 발현 및 혈액학적 효과Article Published on 2022-04-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adenovirus Adenovirus-vectored vaccine AZD1222 AZD1222 (ChAdOx1 nCoV-19) blood cell cells ChAdOx1 ChAdOx1 nCoV-19 change cleavage cleaved COVID-19 COVID-19 vaccination COVID-19 vaccine detectable Disease progression Effect Evidence expected expression hematologic hematology parameter Hematology parameters host cell host cells Host immune response host immune responses immediate effect immediate effects immune responses immunization immunohistochemistry in vitro in vivo Infection innate immune response intramuscular intravenous investigated mice morbidity morbidity and mortality nCoV neutrophil occurred parameters plasma concentration Platelet platelet activation platelet and white blood cell parameters. produced promote Protein prothrombotic state Respiratory failure response risk S1 protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein sera severe COVID-19 spike spike glycoprotein Spike protein the S1 subunit undetectable vaccination vectored vaccine vehicle Viral Viral particles White blood cell [DOI] 10.3389/fimmu.2022.836492 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of the COVID-19 vaccine BNT162b2 in patients undergoing chemotherapy for solid cancer고형암으로 항암화학요법을 받는 환자에서 코로나19 백신 BNT162b2의 안전성과 면역원성Article Published on 2022-04-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 진단, [키워드] Adverse adverse event Anti-S1 antibody Antibody titer BNT162b2 BNT162b2 mRNA cancer patient Cancer patients Chemotherapy COVID-19 severity COVID-19 vaccine cytotoxic Cytotoxic chemotherapy dose ELISA evaluated group groups healthy volunteer immune Immune checkpoint chemotherapy Inflammatory cytokine inhibitor investigated Japan median no difference no significant difference not differ occurred of BNT162b2 Patient pre-vaccination reported S1 protein Safety SARS-CoV-2 vaccination second dose second vaccination Serious Adverse Event serum IgG significantly lower solid cancer therapy three groups vaccination [DOI] 10.1016/j.jiac.2021.12.021 PMC 바로가기 [Article Type] Article
Recombinant VLPs empower RBM peptides showing no immunogenicity in native SARS-COV-2 protein to elicit a robust neutralizing antibody response재조합 VLP는 천연 SARS-COV-2 단백질에서 면역원성을 나타내지 않는 RBM 펩타이드를 강화하여 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-04-012022-09-11 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Antigen antigenicity Antisera candidate carrier protein core antigen coronavirus demonstrated effective delivery elicit epitope Epitopes HBcAg immunization in vitro inactivated indicate KLH linear mice motif Multi-epitope vaccine Neutralizing activity neutralizing antibody Neutralizing antibody response New overlapping Particle peptide peptide epitope peptides Protein RBM reactivity receptor binding motif receptor-binding motif Receptor-binding motif (RBM) recombinant respiratory robust S1 protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Vaccine variants virus virus infection virus mutation Virus-like particle virus-like particles Virus-like particles (VLPs) VLP VLPs [DOI] 10.1016/j.nano.2022.102527 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal deathSARS-CoV-2 스파이크 단백질은 비 세포 자율 해마 신경 세포 죽음을 통해 마우스에서인지 결핍 및 불안과 같은 행동을 유도합니다Article Published on 2022-03-312022-09-12 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] accompanied Activation acute respiratory syndrome administration autonomous cell death cognitive contribute coronavirus COVID-19 patient death disorder Glia glial cell in vitro in vivo induce Infection interleukin-1β mechanism neurological Neurological symptom neuronal pathogenic S1 protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein the S1 protein [DOI] 10.1038/s41598-022-09410-7 PMC 바로가기 [Article Type] Article