Outcome of SARS-CoV-2 infection among patients with common variable immunodeficiency and a matched control group: A Danish nationwide cohort studyArticle Published on 2022-09-232022-11-16 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] age calculate Clinical outcome cohort study common variable immunodeficiency (CVID) conducted Contact control group Coronavirus-2 Course COVID-19 Cox regression CVID death detectable estimate Gender General population groups hospital Immunity immunodeficiency in both groups inborn errors of immunity (IEI) incidence rate increased risk individual Infection mechanical ventilation not differ Novel coronavirus outcome Patient Re-infection risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe adult respiratory coronavirus-2 (SARS-CoV-2) severe novel coronavirus 2019 (COVID-19). severity the timing was used [DOI] 10.3389/fimmu.2022.994253 PMC 바로가기
Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial계층적 복합 종점을 기반으로 한 연구의 설계 및 분석: DARE-19 시험의 통찰력Article Published on 2022-09-012022-09-11 Journal: Therapeutic innovation & regulatory science [Category] 임상, [키워드] accompanied Analysis analyzed cardiometabolic Cardiometabolic risk factors clinical endpoint Clinical endpoints Clinical outcome clinical outcomes clinically component components Composite composite endpoint COVID-19 COVID-19 pneumonia Dapagliflozin described detectable disease Effect Endpoint example flexible handling Hierarchical composite endpoints hospitalized patient hospitalized patients ICH include inhibitor insight Interpretation mechanism mechanism of action Missing data offered Pneumonia power primary endpoints randomized trial ranking Sample size SGLT2 inhibitors statistical suggested the primary endpoint therapeutic to define Treatment Trial Win odds. with COVID-19 [DOI] 10.1007/s43441-022-00420-1 PMC 바로가기 [Article Type] Article
The Perception of Preparedness in Undergraduate Nursing Students During COVID-19Research article Published on 2022-09-012022-10-05 Journal: Journal of Professional Nursing [Category] 임상, [키워드] changed clinical experience Clinical simulation Comfort Coronavirus disease 2019 COVID-19 Data collection expressed Facebook group healthcare impacted learning less Nurse Nursing online learning participant Patient Perception platform Practice preparedness question readiness reduction in Research Result Sample size student Support survey technique Topic transitioned Undergraduate nurse [DOI] 10.1016/j.profnurs.2022.06.002 [Article Type] Research article
Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical TrialArticle Published on 2022-09-012022-11-15 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis antibody blinded clinical COVID-19 Delta diagnosed Diagnosis double-blind Efficacy Elecsy evaluate evaluated had no higher odd immunoassay increase in Infection Infectious disease injection median Moderna mRNA-1273 occurred Odds ratio Older omicron participant PCR PCR-confirmed COVID-19 phase Phase 3 Placebo placebo recipient placebo-controlled polymerase chain Randomized risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Seroconversion serum sample severe COVID-19 Swab tested The United States Treatment Trial vaccination Vaccination Status Vaccine vaccinee [DOI] 10.7326/M22-1300 PMC 바로가기
A Virtual, Simulated Code White for Undergraduate Nursing StudentsRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: The Canadian journal of nursing research = Revue canadienne de recherche en [Category] 임상, [키워드] benefit Care code Code white collected control group control groups COVID-19 COVID-19 pandemic detect Effectiveness evaluate exhibiting groups Health increasingly Intervention intervention group iterations knowledge measure Mental mental health Nurse Nursing organized participant physical promoted public health qualitative data Randomly response Sample size student undergraduate nursing education verbal virtual simulation while white workplace violence. [DOI] 10.1177/08445621221101290 PMC 바로가기 [Article Type] Randomized Controlled Trial
Remdesivir Plus Dexamethasone Versus Dexamethasone Alone for the Treatment of Coronavirus Disease 2019 (COVID-19) Patients Requiring Supplemental O2 Therapy: A Prospective Controlled Nonrandomized Study코로나바이러스 질병 2019(COVID-19) 환자 치료를 위한 렘데시비르 플러스 덱사메타손 대 덱사메타손 단독 요법: 보충 O2 요법이 필요한 환자: 전향적 통제된 비무작위 연구Controlled Clinical Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제, [키워드] 30-Day mortality Antiviral baseline calculated clinical outcomes cohorts Combination Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRP D-dimer Dexamethasone drug effective Endpoint enrolled evaluate evaluated faster fibrinogen FiO2 group groups Hospitalization IMPROVE independent Inflammatory inflammatory markers Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves laboratory characteristics log-rank test median Mortality neutrophil neutrophil/lymphocyte ratio no differences occurred primary endpoint primary endpoints Prospective reducing mortality reduction in reduction in mortality Remdesivir Respiratory failure Respiratory function Sample size SARS-CoV-2 clearance secondary Secondary endpoints shown significant difference significant differences survival the log-rank test therapy treat Treatment viral clearance Viral clearance. were used [DOI] 10.1093/cid/ciac014 PMC 바로가기 [Article Type] Controlled Clinical Trial
Infections with the SARS-CoV-2 Delta variant exhibit fourfold increased viral loads in the upper airways compared to Alpha or non-variants of concernSARS-CoV-2 Delta 변이체 감염은 우려되는 알파 또는 비 변이체에 비해 상기도에서 4배 증가된 바이러스 부하를 나타냅니다.Article Published on 2022-08-172022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age all age group all age groups Alpha Alpha variant B.1.1.7 B.1.617.2 coronavirus Delta delta variant dominant Evidence evidenced genomic Genomic surveillance group groups in viral no difference Older age other variants reported respiratory sample Respiratory samples Sample size SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sex significantly lower suggested Surveillance the SARS-CoV-2 Transmissibility upper airway vaccination variant variants Viral load viral loads Wuhan strain [DOI] 10.1038/s41598-022-18279-5 PMC 바로가기 [Article Type] Article
Attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia케냐, 말리, 잠비아에서 매력적인 표적 설탕 미끼 3상 시험Clinical Trial Published on 2022-08-092022-09-11 Journal: Trials [Category] 임상, 치료제, [키워드] adaptive ARMS Attractive targeted sugar bait children Cluster cluster separation Cluster-randomized controlled trial Clusters Cohort Contamination Controlled trial core covariate covariates COVID-19 pandemic detect determine dinotefuran Effects External validity Follow-up Imbalance IMPROVE incidence include insecticidal insecticide interim analysis internal validity Intervention Kenya kill Longevity malaria morbidity mosquito density Open-label open-label design phase III trial Prevalence Primary outcome Primary outcomes randomization receive reduce reduction in reductions in Restricted resulting risk Sample size secondary outcome strength Structure sugar threat Transmission transmission pattern Trial Two-arm Validity Variation vector vector control Vector control. vectors [DOI] 10.1186/s13063-022-06555-8 PMC 바로가기 [Article Type] Clinical Trial
Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workersResearch article Published on 2022-08-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] SARS, 신약개발, 임상, [키워드] 95% CI 95% CIs Adverse assigned Asymptomatic benefit Combination conducted COVID-19 Daily double-blind eligible event generally mild group HCQ healthcare worker Hydroxychloroquine IgM/IgG individual laboratory-confirmed objective outcome Placebo placebo group placebo-controlled randomized trial pre-exposure prophylaxis Prophylaxis randomized clinical trial randomized trial Randomly Result risk risk ratio Sample size SARS-CoV-2 screened Spain symptomatic TDF/FTC tenofovir tenofovir disoproxil Venezuela was performed [DOI] 10.1016/j.cmi.2022.07.006 [Article Type] Research article
Network methods and design of randomized trials: Application to investigation of COVID-19 vaccination boosters네트워크 방법 및 무작위 시험 설계: 코로나19 백신 부스터 조사에 적용Article Published on 2022-08-012022-09-11 Journal: Clinical Trials (London, England) [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, 치료제, [키워드] Analysis antibody tests application approach approval arise booster Booster vaccine booster vaccines can be used Characteristics Clinical efficacy Cluster Combination consequence Contact COVID-19 COVID-19 vaccination detectability disease Effect Efficacy enrolled error evaluate the effect Evidence evidence of feasible flexible framework Guidance HIV HIV prevention incidence Infection infections infectiousness information intervention effect Intervention effects magnitude Molecular epidemiology motivation network network science. neutralizing antibody novel populations Pragmatic provide random Randomized randomized trial randomized trials reduce cost Sample size SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants Spread Standard of care statistical Study design susceptibility Transmission Trial United Kingdom Vaccine vaccine efficacy variant [DOI] 10.1177/17407745221111818 PMC 바로가기 [Article Type] Article