SARS-CoV-2 biology – Page 2 – Communicable Diseases Research

Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies

항 바이러스 약물 테스트 및 유전자 기능 연구를위한 비 감염성 SARS-COV-2 레플리 콘의 구성

Article

Published on 2021-08-252022-08-31
Journal: Journal of Virology
[Category] MERS, SARS, 신약개발, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral compounds antiviral drug antiviral drugs antivirals BAC Bacterial biosafety biosafety level Biosafety Level 3 BSL2 BSL3 catalytic site catalytic sites catastrophic caused chromosomal construction contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic deleting demonstrated detect DNA dose-dependent manner drug Drug administration effective vaccine Effective vaccines effort expressing food function functions genetics global public health in viral inhibited level 2 level 3 nano luciferase nLuc nonstructural protein 15 nucleocapsid nucleocapsid protein outbreak pandemic performed Plasmid principle proof Protein reduced Remdesivir Replication replicon reporter respiratory resulting reverse genetics. SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus significantly Spread Testing the SARS-CoV-2 transcript transfecting Vero E6 VERO E6 cells Viral viral pathogen viral replication Viral RNA
[DOI] 10.1128/JVI.00687-21 PMC 바로가기 [Article Type] Article

Increase of SARS-CoV-2 RNA load in faecal samples prompts for rethinking of SARS-CoV-2 biology and COVID-19 epidemiology

대변 샘플에서 SARS-CoV-2 RNA 로드의 증가는 SARS-CoV-2 생물학 및 COVID-19 역학에 대한 재고를 촉구합니다

Research Article

Published on 2021-07-012022-09-11
Journal: F1000Research
[Category] MERS, SARS, 치료기술,

SARS-CoV-2: An Overview of Virus Genetics, Transmission, and Immunopathogenesis

Review

Published on 2021-06-102022-10-29
Journal: International Journal of Environmental Research an
[Category] COVID-19, MERS, SARS,

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

44개의 Sarbecovirus 게놈을 비교하여 SARS-CoV-2 유전자 함량 및 COVID-19 돌연변이 영향

Comparative Study

Published on 2021-05-112022-09-10
Journal: Nature Communications
[Category] SARS, 변종, 유전자 메커니즘, 치료법,

SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental Models

Pharmacology

Published on 2021-04-222022-10-31
Journal: Frontiers in Pharmacology
[Category] COVID-19,

[키워드] ACE-2 acute respiratory syndrome Antiviral blood vessel organoid Calu-3 cause cell line cells clinical sample coronavirus COVID-19 develop drug design Drug discovery epithelial cell epithelial cells experimental model experimental models expression H1299 HEK-293 human Angiotensin-converting enzyme human lung inefficient Infection intestinal epithelial cells Intestinal Organoids investigated Laboratory lung organoids Model molecular molecular target Molecular targets morbidity and mortality mouse model Novel coronavirus outbreak outcomes pandemic Pathogenesis potential molecular Protein recent receptor Research researcher SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection sequencing data spike target targets the SARS-CoV-2 therapeutic transgenic Treatment outcome Vero cells viral genome viral life cycle viral pathogen viral pathogenesis Viral protein viral titer X-ray
[DOI] 10.3389/fphar.2021.638334 PMC 바로가기 [Article Type] Pharmacology

Infectious Clones Produce SARS-CoV-2 That Causes Severe Pulmonary Disease in Infected K18-Human ACE2 Mice

감염성 클론은 감염된 K18-인간 ACE2 마우스에서 심각한 폐 질환을 일으키는 SARS-CoV-2를 생성합니다

Research Article

Published on 2021-04-202022-09-10
Journal: mBio
[Category] MERS, SARS, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 benefit Brain brains causative agent cause caused changes in clinical disease clinically clone consolidation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine development Cytokines develop effective facilitate feature Genetic hACE2 human ACE2 immunopathology in viral in vivo Infection infectious clones K18-hACE2 K18-hACE2 mice Laboratory lung Lung infection Lung pathology Lungs mCherry mice morbidity Mortality pandemic Pathogenesis Patient Pneumonia Postinfection Produce produced pulmonary Research respiratory respiratory viruses RG-rescued SARS-CoV-2 virus RG-rescued SARS-CoV-2 viruses SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 research SARS-CoV-2 toolkit SARS-CoV-2-mCherry severe acute respiratory syndrome Coronavirus severe COVID-19 structures toolkit utility Validity valuable resource variety Viral Viral pneumonia viruses weight loss
[DOI] 10.1128/mBio.00819-21 PMC 바로가기 [Article Type] Research Article

A novel cell culture system modeling the SARS-CoV-2 life cycle

SARS-CoV-2 수명 주기를 모델링한 새로운 세포 배양 시스템

Research Article

Published on 2021-03-122022-08-13
Journal: PLoS Pathogens
[Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

[키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agent Antiviral antivirals approach Author biosafety biosafety level BSL-2 BSL-2 laboratory BSL-3 can be used cause Cell Cell culture cell line cells chloride Complete coronavirus COVID-19 Critical Culture culture system Deletion dissect drug effective evidenced experimental system expresse expressing facilitate genetic recombination genetics genomic GFP global pandemic impede independent intein life cycle MERS MERS-CoV N monensin monensin sodium N gene N protein neutralization nucleocapsid Nucleocapsid gene Particles passage Phosphorylation powerful tool producer cells Protein Proteins replacing Replication replication-competent SARS-CoV-2 reporter reporter gene required Research residue respiratory Salinomycin SARS-CoV SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 N SARS-CoV-2 virus secure Sequence analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sodium the cells the N protein the SARS-CoV-2 this system trans Transcription vector vectors Viral viral genome viral infection viral life cycle Viral RNA virion assembly Virus life cycle
[DOI] 10.1371/journal.ppat.1009439 PMC 바로가기 [Article Type] Research Article

The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19

Review

Published on 2021-03-092022-10-29
Journal: Stem Cell Reports
[Category] COVID-19, SARS,

A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care

Reviews

Published on 2021-02-112022-10-30
Journal: Journal of Biological Rhythms
[Category] COVID-19, MERS,

Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics

다이아몬드 광원: SARS-CoV-2 생물학 및 치료제에 대한 기여

Article

Published on 2021-01-292022-08-31
Journal: Biochemical and Biophysical Research Communication
[Category] SARS, 신약개발,