Development of a cost-effective ovine antibody-based therapy against SARS-CoV-2 infection and contribution of antibodies specific to the spike subunit proteinsSARS-CoV-2 감염에 대한 비용 효율적인 양 항체 기반 요법의 개발 및 스파이크 소단위 단백질에 대한 항체의 기여Article Published on 2022-07-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affinity antibodies antibody Antibody titre antibody-based therapy Antigen approval approved B.1.1.529 complement complement fixation convalescent plasma COVID-19 demonstrated development evaluated fixation generate highly active Immunoglobulin in vitro Neutralising activity omicron performed phagocytosis plasma polyclonal antibodies polyclonal antibody protective immunity Protein provide raised Regulatory S1 and S2 S2 subunit SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection sheep Spike protein subunit therapy therapy for COVID-19 variant virus was collected widespread [DOI] 10.1016/j.antiviral.2022.105332 PMC 바로가기 [Article Type] Article
Screening Protocol and Prevalence of Venous Thromboembolic Disease in Hospitalized Patients With COVID-19COVID-19로 입원한 환자에서 정맥 혈전색전증의 스크리닝 프로토콜 및 유병률Observational Study Published on 2022-07-012022-09-11 Journal: Journal of Ultrasound in Medicine [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] AUC benefit Cohort Computed tomography conducted COVID-19 COVID-19 patient COVID-19 patients CSS Cytokine storm syndrome D-dimer Deep vein Deep vein thrombosis detect determine diagnosing dimer disease DVT endothelial damage evidenced facilitate Factor Future hospitalized patients hypercoagulability hypoxia immobilization induce Inflammatory laboratory parameter Mortality no difference no differences observational study Older Patient patients with COVID-19 performed point-of-care positive Prevalence prospective observational study pulmonary computed tomography Pulmonary embolism ROC Curve SARS-CoV-2 disease SARS-CoV2 Screening screening strategy Sensitivity and specificity Society sustained syndrome the cytokine storm the patient Thromboprophylaxis thrombosis Trial Ultrasound undergo venous thromboembolic [DOI] 10.1002/jum.15850 PMC 바로가기 [Article Type] Observational Study
Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 diseaseS1 소단위를 발현하는 뉴캐슬병 바이러스 벡터를 사용한 햄스터의 비강내 예방접종은 SARS-CoV-2 질병으로부터 동물을 보호합니다Article Published on 2022-06-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administer administration animals breath claimed coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Critical effective Efficacy elicited expressing hamster hamsters human clinical trial humoral immune responses immune responses long term lung damage mice Neutralizing antibodies newcastle disease virus pandemic phase prevented PROTECT Protective recent recorded recorded history reduced respiratory respiratory tract Safe SARS-CoV-2 SARS-CoV-2 disease severe acute respiratory syndrome Coronavirus short term significantly the disease the S1 subunit vaccination Vaccine vaccine candidate variant vectored vaccine Viral Viral load while [DOI] 10.1038/s41598-022-13560-z PMC 바로가기 [Article Type] Article
Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection폐 공간 프로파일링은 치명적인 SARS-CoV-2 감염이 있는 COPD 환자의 T 세포 서명을 나타냅니다Article Published on 2022-06-072022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] airways Antigen CD4 CD45 CD45RO Cell characterized chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) chronic obstructive pulmonary disease (COPD). COPD COVID-19 COVID-19 infection death died downregulation expression Gene Expression immune microenvironment immune response invasive lung Lung disease Lung diseases lung parenchyma memory memory T memory T cell obstructive pulmonary disease parenchyma Patient patients priming Profiling Protein proteomic pulmonary disease receptor ROI ROIs SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 disease 2019 SARS-CoV-2 entry SARS-COV-2 infection sick signature significant enrichment Smokers Still structural gene T cell T cell response T cells T-lymphocyte T-lymphocytes transcriptomic underlie vessel vessels with COVID-19 [DOI] 10.3390/cells11121864 PMC 바로가기 [Article Type] Article
Modeling the population-level impact of treatment on COVID-19 disease and SARS-CoV-2 transmissionResearch article Published on 2022-06-012022-10-05 Journal: Epidemics [Category] COVID19(2023년), SARS, 치료법, [키워드] age candidate COVID-19 COVID-19 disease COVID-19 treatment Critical Critical disease death disease Disease progression downstream driven by drug Drug efficacy Effect Effectiveness ENhance example implementation Infection Infection transmission mathematical mathematical model modeling Pfizer population-level Primary outcome progression Prophylactic Prophylaxis provide reduce reductions in robust SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 transmission the epidemic the United State therapeutic Transmission Treatment vaccination were assessed [DOI] 10.1016/j.epidem.2022.100567 [Article Type] Research article
Development of flow cytometry-based assays to assess the ability of antibodies to bind to SARS-CoV-2-infected and spike-transfected cells and mediate NK cell degranulationSARS-CoV-2 감염 및 스파이크 형질감염 세포에 결합하고 NK 세포 탈과립을 매개하는 항체의 능력을 평가하기 위한 유세포 분석 기반 분석법 개발Article Published on 2022-06-012022-09-11 Journal: Cytometry. Part A : the journal of the Internation [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] antibody Antibody binding Antibody Response Antibody responses Antibody titer Antibody titers assays binding capture Cell cells Clinical studies correlation COVID-19 degranulation demonstrated detect determine develop development Dilution dilution sery Efficiency effort elicited facilitate function functional antibody response healthy control high correlation Immunity IMPROVE infected cell infected cell. infected cells infected individuals magnitude moderate NK cell NK cell degranulation outcome overlap pandemic plasma platform ranged reduce response response rates responses SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2-infected cell SARS-CoV-2-infected cells SARS-CoV-2-infected individual SARS-CoV-2-infected individuals Spearman the SARS-CoV-2 transfected cells Undetermined vaccination [DOI] 10.1002/cyto.a.24552 PMC 바로가기 [Article Type] Article
Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster modelResearch Article Published on 2022-05-052022-10-04 Journal: Science Translational Medicine [Category] SARS, 임상, 진단, 치료법, [키워드] acute respiratory syndrome Adenovirus clinical symptom clinical trial coronavirus coronavirus disease COVID-19 cross-reactive cross-reactive antibody decrease demonstrated description disease disease severity elicited exhibited expresse hamster IgA response immunization Infection Infectious virus intranasal intranasal route intranasally less lung Lung pathology mucosal nasal swab nucleocapsid protein oral platform PROTECT reduced responses robust SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 vaccine SARS-CoV-2-infected hamster Spread the SARS-CoV-2 the spike protein Transmission Viral RNA Viral transmission [DOI] 10.1126/scitranslmed.abn6868 PMC 바로가기 [Article Type] Research Article
Tachycardia as an undescribed adverse effect to the Comirnaty© vaccine (BNT162b2 Pfizer-BioNTech Covid-19 vaccine): Description of 3 cases with a history of SARS-CoV-2 diseaseCase report Published on 2022-05-012022-10-05 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] COVID19(2023년), SARS, 변종, [키워드] adverse effect BNT162b2 description Pfizer-BioNTech SARS-CoV-2 disease Vaccine [DOI] 10.1016/j.eimce.2022.03.002 [Article Type] Case report
A Protective HLA Extended Haplotype Outweighs the Major COVID-19 Risk Factor Inherited From Neanderthals in the Sardinian Population보호 HLA 확장 일배체형은 사르데냐 인구의 네안데르탈인에게서 유전된 주요 COVID-19 위험 요소보다 큽니다Article Published on 2022-04-192022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] 95% CI analyzed Asymptomatic B*18:01 balance carrier carriers chromosome chromosome 3 Combination combinations Course COVID-19 disease course DRB*03 extended haplotype drug Europe evaluated Evolution Extended Factor Frequency Genetic variant Haplotype healthy high risk HLA HLA class I HLA haplotypes HLA-A HLA-A*02:01 Hospitalization immunogenetic factor incidence increased risk Infection investigated KIR KIR genes KIRs Ligand locus lowest Major mechanism moderate disease Mortality Neanderthal Neanderthal Covid-19 risk haplotype outcome Patient pauci-symptomatic Population predicted Protective protective effect reported risk risk factor rs35044562 variant. Sardinia Sardinian Sardinian controls Sardinian population SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 patient severe disease severe SARS severe SARS-CoV-2 shown thalassemia three-loci extended haplotype turn Vaccines variant [DOI] 10.3389/fimmu.2022.891147 PMC 바로가기 [Article Type] Article
Response to Letter to the Editor from Lui et al.: ‘Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS-CoV-2 disease’: prognostic significance of non-thyroidal illness syndrome in the whole spectrum of COVID-19 severityLui et al.의 편집자에게 보낸 편지에 대한 응답: '경증 SARS-CoV-2 질병에서 좋지 않은 결과의 조기 대리 표지자로서의 정상갑상선 질환 증후군': COVID-19의 전체 스펙트럼에서 비갑상선 질환 증후군의 예후적 중요성 심각성Comment Published on 2022-04-012022-09-11 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 바이오마커, [키워드] COVID-19 severity marker Mild outcome prognostic response SARS-CoV-2 disease sick syndrome [DOI] 10.1007/s40618-021-01733-y PMC 바로가기 [Article Type] Comment