SARS-CoV-2 epitope – Page 2 – Communicable Diseases Research

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

교차 반응성 기억 T 세포는 COVID-19 접촉에서 SARS-CoV-2 감염에 대한 보호와 관련이 있습니다

Article

Published on 2022-01-102022-09-10
Journal: Nature Communications
[Category] 진단, 치료기술, 치료법,

Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals

전염병 및 COVID-19 회복기 개인의 교차 반응성 및 단일 반응성 SARS-CoV-2 CD4+ T 세포

Research Article

Published on 2021-12-292022-09-10
Journal: PLoS Pathogens
[Category] SARS, 치료기술, 치료법,

[키워드] Activation allele Amino acid amino acid sequence Amino acid sequences analysis assays Author CD4+ T cell class common cold common cold coronavirus common cold Coronaviruses common cold virus common cold viruses contributed convalescent convalescent individual convalescent individuals coronavirus coronavirus COVID-19 cross-react cross-reactive cross-reactivity defined demonstrated Direct dominant epitope DPB1 elicit elicited Endemic epitope Epitopes Ex vivo frequencies Frequency functional HLA-DP HLA-DR identify immunodominant low frequency marker membrane MHC-II naïve individuals nucleocapsid Nucleocapsid proteins overlapping PBMC peptide peptides Potential prevalent Previous studies previous study proportion protective immunity Protein reactive reagent recognizing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 epitope SARS-CoV-2 epitopes sequence identity shown spike staining stratified subjects suggested T cell T cell epitope T cell epitopes T cell response T cell responses T cells the Spike to define unlikely viruses was used were used world population
[DOI] 10.1371/journal.ppat.1010203 PMC 바로가기 [Article Type] Research Article

EpiCurator: an immunoinformatic workflow to predict and prioritize SARS-CoV-2 epitopes

Bioinformatics

Published on 2021-11-302022-10-28
Journal: PeerJ
[Category] COVID-19,

[키워드] analyzed antigenic antigenicity approaches assist candidate clinical trial Combination Coronavirus 2019 Coverage COVID-19 demonstrated described effective effective vaccine Effectiveness Efficacy Efficiency EpiCurator epitope Epitopes prediction GISAID database global public health glycoprotein HLA alleles binding affinity IEDB Immune Epitope Database immune response immunogenic potential Immunoinformatic approaches in silico in vitro Interaction pandemic predict Prevent RBD Research retrieved SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 genome SARS-CoV-2 virus sequence spike stability the receptor-binding domain the vaccine TLR triggered variants of concern virus genome virus spread
[DOI] 10.7717/peerj.12548 PMC 바로가기 [Article Type] Bioinformatics

High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Article

Published on 2021-11-222022-10-04
Journal: Communications Biology
[Category] MERS, SARS, 바이오마커, 변종, 진단,

[키워드] Adaptive immunity analyzed antibody epitopes Antibody Response Antigen applied approach Bacterial binding coronavirus 2 Coronaviruses COVID-19 cross-reactive D614G Data mining data-driven Diagnostic markers disease severity dominant epitope effective vaccine elicit epitope epitope mapping Evolution of SARS-CoV-2 highlight humoral identify immune response in silico analysis infected patient large cohort Mild motif mutant Mutant SARS-CoV-2 neutralization activity organism other coronavirus Patient peptide platform proteome proteomes random reduced Region repertoire respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 epitope SARSCoV-2 serum samples severe disease specificity Spread Strains subject the vaccine Therapies therapy treat viral infection with COVID-19
[DOI] 10.1038/s42003-021-02835-2 PMC 바로가기 [Article Type] Article

Mass spectrometric identification of immunogenic SARS-CoV-2 epitopes and cognate TCRs

면역원성 SARS-CoV-2 에피토프 및 동족 TCR의 질량 분석 식별

420

Published on 2021-11-012022-09-10
Journal: Proceedings of the National Academy of Sciences of
[Category] MERS, SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach best binding affinities caused cell lines cells cellular immune responses conserved coronavirus COVID-19 COVID-19 infection Critical defined effective elicit epitope Epitopes Evidence expressing glycoprotein histocompatibility complex humoral Humoral response humoral responses immune immune protection immune responses immunogenic immunogenicity In silico method in vitro increasingly Infection infectious kill killing major histocompatibility complex malignant disease malignant diseases mass spectrometric mass spectrometry membrane membrane glycoprotein MGP MHC MHC peptide nsp13 peptide peptides predict processed Protein recognize recognizing Region reported respiratory robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2 peptide SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance specificity T cell T cell epitope T cell epitopes T cell response T cell responses T cells tandem Tandem mass spectrometry target cells TCR TCR-T the disease the SARS-CoV-2 therapy to define Treatment variants
[DOI] 10.1073/pnas.2111815118 PMC 바로가기 [Article Type] 420

Potential Antigenic Cross-reactivity Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue Viruses

중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)와 뎅기열 바이러스 간의 잠재적 항원 교차 반응성

Article

Published on 2021-10-052022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat
[Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed antibodies antibody Clinical data consequence Control control group coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-reactivity Dengue Dengue fever dengue virus dengue. diagnosed domain ELISA ELISA testing envelope protein enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes False-positive healthy individual identify IgA IgG IgG antibodies IgM Immunoglobulin Immunoglobulin G immunoglobulin M Implications in-silico include individual Infection Laboratory features lead Patient Patient care performed positive Potential Protein public health Rapid test respiratory S protein SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology serum sample serum samples severe acute respiratory syndrome Coronavirus similarities similarity Spike protein Structural analysis subject Support tested the S protein the spike protein West West Nile
[DOI] 10.1093/cid/ciaa1207 PMC 바로가기 [Article Type] Article

Profiling CD8 + T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants

COVID-19 회복기의 CD8 + T 세포 에피토프를 프로파일링하면 SARS-CoV-2 변이체에 대한 감소된 세포 면역 반응이 나타납니다

Article

Published on 2021-09-142022-09-11
Journal: Cell Reports
[Category] SARS, 변종,

[키워드] addition alleles binding CD8 CD8+ CD8+ T cells Cellular immune response cellular immunity circulating variants complex conserved contribute convalescent COVID-19 COVID-19 patient COVID-19 patients crystal structure delta variant determine disease severity epitope epitope peptide Epitopes HLA HLA-A human coronaviruses identify Immunity K417 mutated Mutation new SARS-CoV-2 patients peptides Profiling reduce reduced reveal SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants. severity of COVID-19 significantly Spike protein T cell T cell epitope T cell epitopes T cell response T cell responses T cells the disease the spike protein Transmissibility variants
[DOI] 10.1016/j.celrep.2021.109708 PMC 바로가기 [Article Type] Article

Bioinformatics Prediction of SARS-CoV-2 Epitopes as Vaccine Candidates for the Colombian Population

Article

Published on 2021-07-172022-10-28
Journal: Vaccines
[Category] COVID-19,

Deep learning identifies antigenic determinants of severe SARS-CoV-2 infection within T-cell repertoires

Article

Published on 2021-07-122022-10-04
Journal: Scientific Reports
[Category] SARS, 진단,

The landscape of antibody binding in SARS-CoV-2 infection

SARS-COV-2 감염에서 항체 결합의 풍경

Research Article

Published on 2021-06-182022-08-13
Journal: PLoS Biology
[Category] Biochemistry, MERS, SARS, 진단, 치료법,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody binding B cell epitope B cell epitopes binding convalescent coronavirus coronavirus correlated CoV proteins COVID-19 CoVs cross-reactivity develop diagnostic Diagnostic accuracy diagnostics ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes homologous human CoVs human sera humoral immunogen humoral immunogens identify illness Illness severity induce membrane naïve nucleocapsid occurred ORF3a ORF8 protein ORF8 proteins other coronavirus other coronaviruses pandemic peptide peptide sequences Profiling Protein Proteins proteome reactive reactivity respiratory robust antibody response robust antibody responses SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-COV-2 infection SARS-CoV-2 proteome sequence severity the SARS-CoV-2 Therapeutics ultradense peptide microarray Vaccines
[DOI] 10.1371/journal.pbio.3001265 PMC 바로가기 [Article Type] Research Article