Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjectsArticle Published on 2022-09-302022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 치료제, [키워드] affected age antiviral drug approved association baseline blood sample BMI calculated collected comparison Concentration COVID-19 COVID-19 patients COVID-19 severity Efficacy enrolled evaluated glomerular filtration rate GS-441524 ICU identify independent predictor Inpatient Inpatients inter-individual Liver function Logistic regression metabolite Multiple linear regression Multiple regression analysis parameter Patient pharmacokinetic plasma Remdesivir renal renal function required Research SARS-CoV-2 SARS-CoV-2 infections Sex Standard-dose statistical subject transaminase treated Treatment Variability variables were assessed were measured were used [DOI] 10.1093/jac/dkac234 PMC 바로가기
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in IcelandArticle Published on 2022-09-282022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] antibody binding BNT162b2 booster booster vaccination Combination Delta delta variant Effect greater Iceland infections inhibitory activity initiated majority mRNA mRNA vaccine mRNA-1273 observé omicron qPCR test reflected risk risk of infection SARS-CoV-2 infections SARS-CoV-2 variant Spread vaccination vaccination against COVID-19 vaccination schedule Vaccine virus [DOI] 10.1038/s41467-022-33076-4 PMC 바로가기
Early Detection of SARS-CoV-2 Epidemic Waves: Lessons from the Syndromic Surveillance in Lombardy, ItalyArticle Published on 2022-09-282022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] alarm ARIMA average coded detect detection diagnoses Early detection emergency department evaluated EWMA models Frequency Health Italy lesson Local lombardy Occurrence outlier pandemic predictor Regression model respiratory symptom respiratory symptoms SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 infections Surveillance syndrome Syndromic surveillance. [DOI] 10.3390/ijerph191912375 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Antigen in Urine of Hospitalized Patients With Coronavirus Disease 2019Article Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] absence Accuracy acute respiratory syndrome Admission antibodies Blood C-reactive protein Compound coronavirus coronavirus 2 coronavirus disease Course COVID-19 disease severity dissemination early phase hospitalized patient immunoassay Infection intensive care units lactate dehydrogenase lymphopenia marker nucleocapsid nucleocapsid antigen Patient patients hospitalized patients with SARS-CoV-2 plasma polymerase chain positive reflect respiratory SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 nucleocapsid severe COVID-19 severity Severity of disease tested urinary Urine Urine. [DOI] 10.1093/infdis/jiac073 PMC 바로가기
SARS-CoV-2 variant trends in Ireland: Wastewater-based epidemiology and clinical surveillance아일랜드의 SARS-CoV-2 변종 경향: 폐수 기반 역학 및 임상 감시Article Published on 2022-09-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha Alpha variant average circulating circulating variant circulating variants clinical clinical sample clinical samples collected Community complement conducted confirmed case confirmed cases correlated COVID-19 case COVID-19 disease Delta delta variant demonstrated determine Digital digital PCR disease Effectiveness Epidemiology Genome Genomic surveillance greater highlight identify Infection Ireland MONITOR National notification offer Prevalence prevalence of COVID-19 quantification RNA RNA concentration SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 lineage SARS-CoV-2 N1 SARS-CoV-2 variant sequence sequenced Sequencing significantly Spread Surveillance Validity variant variants variants of concern Viral RNA VOCs wastewater Wastewater surveillance. [DOI] 10.1016/j.scitotenv.2022.155828 PMC 바로가기 [Article Type] Article
Age and product dependent vaccine effectiveness against SARS-CoV-2 infection and hospitalisation among adults in Norway: a national cohort study, July-November 2021Article Published on 2022-09-022022-11-16 Journal: BMC Medicine [Category] SARS, 변종, [키워드] adjusted Admissions age AZD1222 BNT162b2 booster Care change changes in Cohort studies cohort study Combination Comorbidities conditions confidence interval country covariate COVID-19 COVID-19 vaccine COVID-19 vaccines death delta variant dominant dose effective Effectiveness facilitated groups hazard heterologous schedules highest hospitalisation hospitalisations Hospitalization Infection intensive care intensive care units knowledge Mortality mRNA mRNA-1273 National Norway pandemic population-based cohort proportional hazards models provided receiving regimen regimens registries remained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections second dose Sex Support the vaccine vaccination Vaccine vaccine dose vaccine effectiveness. waned [DOI] 10.1186/s12916-022-02480-4 PMC 바로가기
Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In VivoArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 affected approach block comparable decoy receptors dimeric effective Efficiency escape mutations fused greater in vivo inhibit SARS-CoV-2 isolates monoclonal antibodies monomeric MoonTag multimerization Mutation mutations neutralization neutralized Neutralizing offer provide sACE2 sACE2. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SunTag Therapeutic treatment Treatment trimeric unlikely variants of concern [DOI] 10.1002/advs.202201294 PMC 바로가기
Differences in pediatric SARS-CoV-2 symptomology and Co-infection rates among COVID-19 Pandemic waves코로나19 팬데믹 파동별 소아 SARS-CoV-2 증상 및 동시 감염률 차이Article Published on 2022-09-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] changes in Co-infection COVID-19 demographics difference epidemic wave occurred pediatric SARS-CoV-2 SARS-CoV-2 epidemiology SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variants the United State United States [DOI] 10.1016/j.jcv.2022.105220 PMC 바로가기 [Article Type] Article
Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinoloneResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] A549 activity acute respiratory syndrome addition Analysis AUC binding binding affinity Bioinformatics analysis candidate caused Cell cell line clinical investigation Colon conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 (Coronavirus disease 2019) COVID-19 infections dataset drug drug target effector memory Efficacy evaluated exhibited FIVE gene signature global pandemic human lung IC50 identification immune immunomodulation immunomodulatory immunosuppressive in vitro in vivo Inflammation Inflammatory Lungs peak plasma concentration pharmacokinetics positive-sense RNA virus respiratory infection SARS-CoV-2 SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 drug SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pathogenesis SARS-CoV-2-infected patient suggested T cell therapeutic options therapeutic potential therapy threat transcriptomic translation translational vaccine candidates value [DOI] 10.1016/j.compbiomed.2022.105814 [Article Type] Research article
Detecting Waning Serological Response with Commercial Immunoassays: 18-Month Longitudinal Follow-up of Anti-SARS-CoV-2 Nucleocapsid AntibodiesArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] Abbott Accuracy acute respiratory syndrome adjusted Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 immune response antibodies antibody Antibody concentrations Antibody detection Architect cohorts commercial immunoassay conducted convalescent individual coronavirus coronavirus disease COVID-19 cumulative dependent on Detection limit Elecsy ELISA enzyme-linked immunosorbent evaluated Follow-up Health care worker heterogenous highest IgG immune responses immunoassay immunoassays incidence individual Infection longitudinal lowest nucleocapsid protein Patient Reinfection response Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections selected serological serological kinetics serum serum antibody Surveillance tested the SARS-CoV-2 threshold unique waning antibody. [DOI] 10.1128/spectrum.00986-22 PMC 바로가기