Discovery of a Phage Peptide Specifically Binding to the SARS-CoV-2 Spike S1 Protein for the Sensitive Phage-Based Enzyme-Linked Chemiluminescence Immunoassay of the SARS-CoV-2 AntigenSARS-CoV-2 항원의 민감한 파지 기반 효소 연결 화학발광 면역분석을 위한 SARS-CoV-2 스파이크 S1 단백질에 특이적으로 결합하는 파지 펩티드의 발견Article Published on 2022-08-232022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료제, [키워드] albumin Amino acid amino acid sequence amplification antigen recognition binding site bovine bovine serum albumin chemiluminescence immunoassay conditions COVID-19 pandemic detect diagnose Dissociation constant Economy Effect exhibited expressing healthcare high affinity hydrogen hydrogen bond network hydrophobic immunoassay Interaction molecular docking N-terminal domain peptide peptides phage probe Protein pseudovirus S1 subunit Saliva SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S1 SARS-CoV-2 S1 protein selective sensitive sensitivity serum albumin specificity spike Spread supported target target protein the S1 subunit the SARS-CoV-2 transducing transmembrane protein [DOI] 10.1021/acs.analchem.2c01988 PMC 바로가기 [Article Type] Article
GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virusGanoderma microsporum의 단백질인 GMI는 SARS-CoV-2 Spike-pseudotyped 바이러스의 감염을 완화하기 위해 ACE2 분해를 유도합니다Article Published on 2022-08-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression activating addition alleviate bafilomycin blocking Cell cell viability cells cloned Cytometry deaths Degradation determined by downregulated dynamin Effect Efficacy examined exhibit expressing flow cytometry fluorescence microscopy fluorescent function Fungal immunomodulatory proteins fungal protein GFP GMI green fluorescent protein HEK293T host cells Human immunomodulatory immunomodulatory functions in vitro induce infecting Infection inhibited inhibiting Interaction lentiviral lung epithelial lung tissue lysosome macrophages mechanism MG132 mice MTT nebulizer not affect overexpressing pandemic Prevent prevention proteasome Protein protein level pseudovirus reduced rescued respiratory responsible S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection SARS-CoV-2. Severe acute respiratory syndrome spike Spike protein Therapeutic strategies triggered Type Vaccine viability viral infection virus was determined western blot [DOI] 10.1016/j.phymed.2022.154215 PMC 바로가기 [Article Type] Article
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies마비 관련 키나아제는 SARS-CoV-2 감염에 필요하며 항바이러스 전략의 세포 표적입니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] AAK1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral strategy approach approaches approved caused cellular combination treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated drugs epithelial cells Erlotinib experiment expression functional GAK Genetic global health Health Host-targeted antivirals human lung human lung epithelial cells implication in vitro inhibited kinase kinase inhibitors kinases late stage life cycle multiple RNA viruses multiple RNA viruses Numb Numb-associated kinases other coronaviruses pandemic pharmacological principle probe reported required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro SARS-CoV-2 life cycle SARS-CoV-2 pseudovirus SARS-CoV-2. severe acute respiratory syndrome Coronavirus siRNA small molecule STK16 sunitinib suppressed synergistic synergistic effect target the SARS-CoV-2 threat treat viral entry wild type [DOI] 10.1016/j.antiviral.2022.105367 PMC 바로가기 [Article Type] Article
Generation and characterization of humanized synergistic neutralizing antibodies against SARS-CoV-2SARS-CoV-2에 대한 인간화 시너지 중화 항체의 생성 및 특성화Article Published on 2022-08-012022-09-12 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody binding chimeric clinical therapy Combination coronavirus coronavirus disease COVID-19 epitope exhibited Generation global public health humanized humanized antibodies humanized neutralizing antibody Local neutralization activity Neutralizing Neutralizing activity neutralizing antibody Protein pseudovirus pseudovirus system RBD recognize SARS-CoV-2 SARS-CoV-2 pseudovirus single-chain antibody synergistic synergistic neutralizing activity. the receptor-binding domain the SARS-CoV-2 [DOI] 10.1002/jmv.27801 PMC 바로가기 [Article Type] Article
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine Research Published on 2022-07-042022-10-05 Journal: Nature biomedical engineering [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome airway antibodies approved CD4+ CD8+ T cell coronavirus COVID-19 vaccine cytokine expression profile domain dose elicit elicited ENhance Exosome hamsters Immunity Infection Inflammatory Intramuscular injection live SARS-CoV-2 lung parenchyma Lungs mice mRNA vaccine mucosal IgA response Preclinical Testing RBD RBD-specific IgG reduced SARS-CoV-2 SARS-CoV-2 pseudovirus severe pneumonia temperature the RBD the vaccine Vaccine vaccine candidates Virus-like particle [DOI] 10.1038/s41551-022-00902-5 [Article Type] Research
Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 InfectionSARS-CoV-2 감염에서 중화와 비교한 항체 의존성 Fc 매개 바이러스 진입 평가Article Published on 2022-05-312022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha antibody antibody dependent enhancement B.1.1.7 B.1.351 B.1.617.2 Beta characterization collected concern convalescent plasma coronavirus coronavirus – COVID-19 correlated Delta determine evaluated Fc-mediated virus entry functional Gamma HEK293 cell HEK293 cells IgM in vivo individuals infecting neutralization neutralization activity neutralization potency neutralization titer Neutralizing P.1 pandemic peaked plasma plasma dilution plasma IgG plasmas pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 strain SARS-CoV-2 variants significantly significantly higher significantly lower spike (S) protein titers variant Variant of concern. viral entry virus virus entry viruses VoC waned Washington while [DOI] 10.3389/fimmu.2022.901217 PMC 바로가기 [Article Type] Article
Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interactionSARS-CoV-2 슈도바이러스 감염의 항체 의존성 향상(ADE)에는 2가 상호작용을 갖는 FcγRIIB 및 바이러스-항체 복합체가 필요합니다Article Published on 2022-03-242022-09-12 Journal: Communications Biology [Category] MERS, SARS, 변종, 진단, [키워드] ADE ADE activity B cells bind blocking complex Critical effective ENhance FcγRIIb in vitro Infection inhibit Interaction lysosome acidification mAb mAbs macropinocytosis mechanism molecular mechanism monovalent Neutralizing RBD S trimer Safe SARS-CoV-2 SARS-CoV-2 pseudovirus Therapies understanding while X-ray [DOI] 10.1038/s42003-022-03207-0 PMC 바로가기 [Article Type] Article
Nanobody-Functionalized Cellulose for Capturing SARS-CoV-2SARS-CoV-2 포획을 위한 나노바디 기능화 셀룰로오스Article Published on 2022-03-082022-09-11 Journal: Applied and Environmental Microbiology [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Bacteria binding biological fluid Blood Cellulose cellulose binding domain cellulose binding protein complement complementary complex coronavirus COVID-19 COVID-19 pandemic cytokine Cytokines D614G variant diagnostics domain Efficiency effort exhibited filtration fluids fungi fusion protein help higher infectivity immobilization IMPROVE infected individuals intrinsic lockdowns mandatory mitigate nanobody nanobody. porous preventative measures proof proof of concept provided pseudoviruses Receptor-binding domain reducing removal SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses sensitivities shown substrate the receptor-binding domain Therapeutic strategies utility vaccination Vaccinations Viral detection Viral load viral spread Viral transmission virus virus viruses wild type [DOI] 10.1128/aem.02303-21 PMC 바로가기 [Article Type] Article
Rapid electrochemical immunodetection of SARS-CoV-2 using a pseudo-typed vesicular stomatitis virus model유사형 수포성 구내염 바이러스 모델을 사용한 SARS-CoV-2의 신속한 전기화학적 면역 검출Article Published on 2022-03-012022-09-11 Journal: Talanta [Category] MERS, SARS, 진단, 치료기술, [키워드] alternative Antigen applicability applied binding Biochip biosensor complex Concentration contribute costly COVID-19 COVID-19 pandemic COVID-19 test COVID-19 tests demonstrated diagnostic diagnostic testing diagnostic tests diagnostics Electrochemical impedance spectroscopy equipment exhibiting feasible Immunosensors integration Intensive labor labor-intensive limitation monoclonal antibodies monoclonal antibody overcome Particle performed plague platform point of care Protein pseudovirus Quantitative Rapid Rapid diagnostic testing real-time RT-PCR RT-PCR RT-PCR test RT-PCR tests S1 protein SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus. sensitivity Specific spike Spike protein supply vesicular stomatitis virus VSV [DOI] 10.1016/j.talanta.2021.123147 PMC 바로가기 [Article Type] Article
Inhibitor screening using microarray identifies the high capacity of neutralizing antibodies to Spike variants in SARS-CoV-2 infection and vaccination마이크로어레이를 사용한 억제제 스크리닝은 SARS-CoV-2 감염 및 백신 접종에서 스파이크 변이체에 대한 항체를 중화하는 높은 능력을 식별합니다Article Published on 2022-02-282022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition anti-S antibody antibody antibody diversity B.1.1.7 B.1.351 B.1.617.2 Cohort convalescent COVID-19 patient convalescent COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines D614G Drug development Efficacy FIVE glass slides group help heterogeneous identify Microarray Mutation NAb titers NAbs neutralization Neutralization assay neutralize Neutralizing antibodies neutralizing antibody neutralizing antibody. neutralizing effect P.1 peptide peptide microarray platform Population prevalent protective effect Protein purified reduce responsible S variant SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 spike Screening serum spike spike-ACE2 These data utility vaccination vaccinee vaccinees variant variants were assessed wild-type [DOI] 10.7150/thno.67038 PMC 바로가기 [Article Type] Article