Acute Surge of Atypical Memory and Plasma B-Cell Subsets Driven by an Extrafollicular Response in Severe COVID-19심각한 COVID-19에서 난포 외 반응에 의해 구동되는 비정형 기억 및 혈장 B-세포 하위 집합의 급성 급증Article Published on 2022-07-082022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, 진단, [키워드] accumulating acute phase acute respiratory syndrome addition anti-SARS-CoV-2 antibody Antibody Response Atypical B cell B cells B-cell B-cell response BCR Cell Clinical severity coronavirus coronavirus disease COVID-19 COVID-19 patient Critical cytokine expression dataset disease course Disease progression disease severity driven by driver elevated Evidence extrafollicular response feature Features groups heterogeneous humoral Humoral immunity Inflammatory investigated mechanism memory B cell moderate naïve pandemic pathogenic pathway PC2 Peripheral blood plasma Plasma cell Plasma cells progression public health receptor response RNA robust Sequencing analysis severe COVID-19 severe COVID-19 patients severe disease severe patients severity single-cell subset Trajectory analysis transcriptional Vaccine with COVID-19 [DOI] 10.3389/fcimb.2022.909218 PMC 바로가기 [Article Type] Article
Testing for rare genetic causes of obesity: findings and experiences from a pediatric weight management program Research Published on 2022-05-132022-10-05 Journal: International journal of obesity (2005) [Category] 유전자 메커니즘, [키워드] absence age analyzed BMI body mass index children clinical feature Cohort evaluated exploratory study expression Genes Genetic genetic cause genetic disorder genetic screening Genetic variant heterozygous hyperphagia identified variant information management MC4R medical record minor allele frequency MOST obesity objective Panel pathway pediatric rare variant receptor reported Research Result risk Sequencing analysis single variant subject syndrome tested Testing variant variants [DOI] 10.1038/s41366-022-01139-7 [Article Type] Research
Vaccine breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota, and OmicronDelta Plus, Iota 및 Omicron에서 SARS-CoV-2 알파 거울 돌연변이로 인한 백신 돌발 감염Article Published on 2022-05-022022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha variant Amino acid amino acid substitution amino acid substitutions Amplicon amplicons Breakthrough infection COVID-19 deep deep sequencing Deep sequencing analysis defined Delta distribution distributions dominant epidemiologically examined Frequency Host human population identify Iota isolate Molecular biology mutant mutant spectra mutants Mutation nasopharyngeal omicron Omicron variants Patient Replication SARS-CoV-2 Sequencing Sequencing analysis Substitution the SARS-CoV-2 Vaccine variant variants Virology virus [DOI] 10.1172/JCI157700 PMC 바로가기 [Article Type] Article
The atlas of ACE2 expression in fetal and adult human hearts reveals the potential mechanism of heart-injured patients infected with SARS-CoV-2태아 및 성인 인간 심장에서 ACE2 발현의 아틀라스는 SARS-CoV-2에 감염된 심장 부상 환자의 잠재적 메커니즘을 보여줍니다Article Published on 2022-04-012022-09-11 Journal: American journal of physiology. Cell physiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis analyzed angiotensin angiotensin I angiotensin I converting enzyme 2 binding calcium Calcium signaling Cardiomyopathy coronavirus dilated cardiomyopathy embryonic embryonic development embryos enzyme expressed gene expressing expression expression level expression profile fetal heart heart failure hearts host cell host cells increase infect infected with SARS-CoV-2 molecular docking Myocyte Numerous organs pathway Pathway analysis Patient potential mechanism Protein protein-protein interaction RAS RAS system regulate Renin renin-angiotensin system reveal risk of infection SARS-CoV-2 Sequencing analysis severe acute respiratory syndrome Coronavirus shown single-cell Spike protein Stage transcription profile upregulated upregulation variant spike various tissue various tissues ventricular was increased was used Wnt signaling pathway [DOI] 10.1152/ajpcell.00169.2021 PMC 바로가기 [Article Type] Article
Increased Expression of Tim-3 Is Associated With Depletion of NKT Cells In SARS-CoV-2 InfectionTim-3의 발현 증가는 SARS-CoV-2 감염에서 NKT 세포의 고갈과 관련이 있습니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Apoptosis binding caspase caused CD147 CD26 Cell circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients CTLA-4 DCs decrease demonstrated dendritic cell dendritic cells Depletion disease severity dysfunction expressed expression expression level Genes healthy individuals IFN-γ IL-10 IL-12 IL-4 immune responses Immunopathogenesis implication Increased increased expression LAG-3 large cohort mechanism mitochondrial mitochondrial gene mitochondrial genes natural killer NKT NKT cell NKT cells outcome patients with COVID-19 PD-1 positively correlated Prognosis progression stage promote receptor receptors respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike scRNA-seq secrete secreted Sequencing analysis severe acute respiratory syndrome Coronavirus severity and prognosis Single-cell RNA sequencing stages therapeutic strategy TIM-3 up-regulated [DOI] 10.3389/fimmu.2022.796682 PMC 바로가기 [Article Type] Immunology
Genomic Analysis of AZD1222 (ChAdOx1) Vaccine Breakthrough Infections in the City of Mumbai뭄바이 시에서 AZD1222(ChAdOx1) 백신 획기적인 감염의 게놈 분석Observational Study Published on 2022-02-112022-09-11 Journal: International journal of clinical practice [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] addition analysed Analysis assigned AZD1222 B.1.617.1 B.1.617.2 Cancer Cancer patients Care ChAdOx1 city Cohort contributed COVID-19 COVID-19 patient delta variant Delta variants disease severity dose feature First wave Genetic Genome genomic genomic sequencing group groups healthcare Healthcare workers hospital immune response India individual individuals Lineage lineages majority manuscript Mumbai not differ observational study Occurrence pandemic Patient Phylogenetic Prevalence prevalent proportion SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutations second wave sequenced sequenced genome sequenced genomes Sequencing analysis severe COVID-19 severe COVID-19 patient severity severity of COVID-19 significantly the disease Therapeutic strategies vaccination variables variant variants of concern [DOI] 10.1155/2022/2449068 PMC 바로가기 [Article Type] Observational Study
Pseudomonas aeruginosa modulates alginate biosynthesis and type VI secretion system in two critically ill COVID-19 patientsResearch Published on 2022-02-092022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] adaptive analyzed ancestors assays attenuate Bacteria bacterial pathogen bacterial superinfection biofilm caused chronic infections contribute COVID-19 COVID-19 patient COVID-19 patients critical COVID-19 patient Critically ill cytotoxicity Evolution facilitate genetic trait Health Host host cell host susceptibility immune clearance increase infected patient lung Macrophage marker mechanism microbial microenvironment modulate morbidity and mortality P. aeruginosa phenotypic Pneumonia Pseudomonas aeruginosa reactive oxygen specy reduced Result SARS-COV-2 infection secretion Sequencing analysis shift strain supplementary material the disease turn Type VI Secretion System viral infection virulence virus infection [DOI] 10.1186/s13578-022-00748-z PMC 바로가기 [Article Type] Research
Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구Article Published on 2022-02-012022-09-11 Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used [DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article
COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen CityArticle Published on 2022-02-012022-11-16 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory distress Anti-Aspergillus IgG Antibody detection Antigen ARDS Aspergillus BALF Bronchoalveolar lavage fluid Care characterized China city clinical care Co-infection collected COVID-19 Culture diagnosed with COVID-19 Diagnosis died eight fungal galactomannan high mortality rate include invasive outcomes Patient positive positive result pulmonary aspergillosis risk Sequencing analysis severe coronavirus disease Shenzhen single center sputum syndrome tested Therapies therapy underlying conditions [DOI] 10.1016/j.jiph.2021.12.015 PMC 바로가기
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력Clinical Trial Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제, [키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used [DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial