Elucidating Design Principles for Engineering Cell-Derived Vesicles to Inhibit SARS-CoV-2 InfectionSARS-CoV-2 감염을 억제하기 위해 세포 유래 소포를 엔지니어링하기 위한 설계 원리 설명Article Published on 2022-05-012022-09-11 Journal: Small (Weinheim an der Bergstrasse, Germany) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition administration antiviral efficacy binding affinities clinic coronavirus decoy decoys develop drug resistance Engineering evade Extracellular Extracellular vesicles feature foundation Health inhibit inhibitor inhibitors knowledge mAb mAbs monoclonal antibody nanovesicles. neutralization overcome Particle pathogen Pathogens principle provide Quantitative Recombinant protein repeated respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virions sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sustained Therapeutics therapy Toxicity Vesicle vesicles Viral viral infections virions [DOI] 10.1002/smll.202200125 PMC 바로가기 [Article Type] Article
Potential inhibitor for blocking binding between ACE2 and SARS-CoV-2 spike protein with mutations돌연변이가 있는 ACE2와 SARS-CoV-2 스파이크 단백질 간의 결합을 차단하는 잠재적 억제제Article Published on 2022-05-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] (+)-Catechin (Pubchem CID: 9064) ACE2 addition binding catechin coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic death E484K GB-1 glycyrrhizic acid Glycyrrhizic acid (Pubchem CID: 14982) Health Organization high mutation rates Infection inhibit inhibited inhibitor K417N K417N mutation L452R Mutation Mutation rates N501Y outbreak pandemic Potential Prophylaxis Protein RBD Receptor binding domain reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein several variant several variants single mutation spike Spike protein T478K Temple Tian variants of SARS-CoV-2 World Health Organization writing Wuhan Wuhan, China [DOI] 10.1016/j.biopha.2022.112802 PMC 바로가기 [Article Type] Article
Interaction of surface glycoprotein of SARS-CoV-2 variants of concern with potential drug candidates: A molecular docking studyArticle Published on 2022-04-072022-11-15 Journal: F1000Research [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] antiviral drug Antiviral effect arising B.1.1.7 B.1.351 B.1.351 variant B.1.617.2 Baricitinib binding binding affinity change conducted COVID-19 determine Dexamethasone drug Drug repurposing experiments Favipiravir Genetic variant investigated mitigate molecular docking molecular dynamics Mutation outbreak Previous studies public health Receptor binding domain Remdesivir residue SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant several variant Surface glycoprotein the SARS-CoV-2 virus Transmission treat virulence VOCs Wuhan, China [DOI] 10.12688/f1000research.109586.1 PMC 바로가기
Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2SARS-CoV-2 S 단백질을 발현하는 폭스바이러스 MVA는 강력한 면역을 유도하고 SARS-CoV-2로부터 붉은털원숭이를 보호합니다Article Published on 2022-03-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] BAL Bronchoalveolar lavage caused Cell clinical trials Computed tomography COVID-19 COVID-19 pandemic cytokine Cytokine storm domain effective vaccine Effective vaccines Efficacy elicited expressing favor Fever full-length SARS-CoV-2 histological histological examination IFNγ IgG antibodies IgG antibody IL-4 immunogenic immunogenicity lung Lung pathology Lungs macaque macaques modified vaccinia virus MVA vaccine nasal mucosa Neutralizing antibodies neutralizing antibody novel Protein Receptor-binding domain reduced reduction rhesus rhesus macaque rhesus macaques robust Safe Safety SARS-CoV-2 SARS-CoV-2 S several variant several variants spike tomography vaccination Vaccine virus load [DOI] 10.3389/fimmu.2022.845887 PMC 바로가기 [Article Type] Article
Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim BladderCOVID-19 모델로 Zebrafish 유충 탐색: 수영 방광에서 SARS-CoV-2 복제 중단 가능성Article Published on 2022-03-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술, [키워드] abortive infection animal animal model animal models Bath bladder wall bloodstream Brain Cell comparable COVID-19 decrease drug Embryo epithelial cell epithelial cells Evidence evidence of Host human ACE2 immunohistochemistry in some in vitro Infection inoculated interferon lung mammalian microinjection no evidence of organ overexpression pathophysiology Prophylactic SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 RNA several variant several variants similarity swim bladder tested therapeutic type I type I interferon Viral load Viral RNA virus wild-type zebrafish [DOI] 10.3389/fcimb.2022.790851 PMC 바로가기 [Article Type] Article
Plant-Derived Antiviral Compounds as Potential Entry Inhibitors against Spike Protein of SARS-CoV-2 Wild-Type and Delta Variant: An Integrative in SilicoApproachSARS-CoV-2 야생형 및 델타 변이체의 스파이크 단백질에 대한 잠재적 진입 억제제로서의 식물 유래 항바이러스 화합물: SilicoApproach의 통합Article Published on 2022-03-082022-09-11 Journal: Molecules [Category] SARS, 변종, 신약개발, 진단, 치료제, [키워드] antagonists Antiviral Antiviral agents antiviral drug antiviral drugs approach approaches binding affinities binding affinity binding energy binding free energies binding free energy binding interaction carried complexes Compound compounds controls Corilagin country COVID-19 COVID-19 infection Delta delta variant develop docking Efficacy exhibited experimental validation explained FIVE free energies glycoprotein greater H-bonds hydrogen hydrophobic interaction hydrophobic interactions Hypericin in silico India lead Ligand ligands Lupeol molecular molecular docking molecular dynamics molecular dynamics and simulations Molecular modeling mutated phytochemical compounds plant compound Potential Protein Research resulting RMSD RMSF S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant second wave selected several variant several variants spike spike glycoprotein Spike protein stability target proteins therapeutic intervention Transmissibility Vaccine Virtual screening virulence was performed while wild-type wild-type SARS-CoV-2 [DOI] 10.3390/molecules27061773 PMC 바로가기 [Article Type] Article
Cross-Neutralizing Breadth and Longevity Against SARS-CoV-2 Variants After Infections감염 후 SARS-CoV-2 변종에 대한 교차 중화 폭 및 수명Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Antibody titer Antibody titers B.1.1.7 B.1.351 breadth center convalescent sera coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cross-neutralizing D614G D614G mutation decrease epitope Epitopes infected with SARS-CoV-2 Infection Longevity maintain neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers not significantly different P.1 pandemic Patient patients produced Protective public health recognize respiratory responsible SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selected sera several variant several variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly sustained variant variants variants of concern virus Virus neutralization viruses VoC VOCs was performed [DOI] 10.3389/fimmu.2022.773652 PMC 바로가기 [Article Type] Article
Real-Time RT-PCR Allelic Discrimination Assay for Detection of N501Y Mutation in the Spike Protein of SARS-CoV-2 Associated with B.1.1.7 Variant of ConcernB.1.1.7 우려 변이체와 관련된 SARS-CoV-2의 스파이크 단백질에서 N501Y 돌연변이 검출을 위한 실시간 RT-PCR 대립형질 판별 분석Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allelic Amino acid B.1.1.7 B.1.351 B.1.617.2 caused characterized circulating concern coronavirus coronavirus disease Coronavirus disease 2019 costly COVID-19 Critical current decrease demonstrated described detection discrimination displaying effort example focus help identify Intensive labor Lineage mutant Mutation N501Y N501Y mutation negative nucleotide P.1 pandemic PCR assay polymorphism positive public health real-time reverse transcriptase real-time RT-PCR respiratory reverse transcriptase reverse transcription PCR RT-PCR RT-PCR assay Sample Sanger sequencing SARS-CoV-2 SARS-CoV-2 lineage sequenced Sequencing several variant several variants severe acute respiratory syndrome Coronavirus single nucleotide Single nucleotide polymorphism SNP specimen spike gene Spread Surveillance tested the Spike turnaround times variants of concern virus VoC VOCs whole-genome whole-genome sequencing wild type [DOI] 10.1128/spectrum.00681-21 PMC 바로가기 [Article Type] Research Article
Reduction of Cell Fusion by Deletion in the Hypervariable Region of the Spike Protein of Mouse Hepatitis VirusArticle Published on 2022-02-152022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Brain Cell fusion cells Characteristics characterized CPE CPEs cultured cells DBT Deletion Effect explain expression level fusion greater growth highlighting hypervariable region in viral involved luciferase activity MHV mouse mouse hepatitis virus Pathogenesis produced reduction Region several variant significantly higher spike gene strain Strains the Spike the spike protein virus growth [DOI] 10.3390/v14020398 PMC 바로가기 [Article Type] Article
Omicron Genetic and Clinical Peculiarities That May Overturn SARS-CoV-2 Pandemic: A Literature ReviewSARS-CoV-2 전염병을 뒤집을 수 있는 오미크론 유전 및 임상 특징: 문헌 검토Review Published on 2022-02-112022-09-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.529 clinical coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drugs elicited global public health immune protection Infection less literature Mutation omicron Omicron variant Overturn pandemic respiratory review SARS-CoV-2 several variant several variants severe acute respiratory syndrome Coronavirus Spike protein the spike protein Therapeutic strategies Therapies Vaccine variant variants of concern VoC wild-type strain [DOI] 10.3390/ijms23041987 PMC 바로가기 [Article Type] Review