Chloroquine- and Hydroxychloroquine-Induced Cardiomyopathy: A Case Report and Brief Literature Review클로로퀸 및 하이드록시클로로퀸으로 유발된 심근병증: 증례 보고 및 간략한 문헌 검토Review Published on 2021-05-182022-09-11 Journal: American journal of clinical pathology [Category] 진단, 치료제, [키워드] administration antimalarial drug Antimalarial drugs cardiac and skeletal muscle Cardiomyopathy Cardiotoxicity caused change Chloroquine clinical trials coronavirus disease Coronavirus disease 2019 correlation country COVID-19 deposition described diagnosed drug Efficacy Endomyocardial biopsy HCQ histologic Hydroxychloroquine identify Including Inclusion inclusion bodies index case LIGHT literature literature review medical history metabolite myopathies Myopathy nonspecific overlap pathologic pathology Patient report review rheumatic disease Rheumatic diseases severe adverse effect Skeletal muscle the patient the United State United States vacuolated was performed were recorded [DOI] 10.1093/ajcp/aqaa253 PMC 바로가기 [Article Type] Review
The Use of In Silico Tools for the Toxicity Prediction of Potential Inhibitors of SARS-CoV-2SARS-CoV-2의 잠재적 억제제의 독성 예측을 위한 In Silico 도구의 사용Article Published on 2021-04-122022-09-10 Journal: Alternatives to Laboratory Animals [Category] MERS, 신약개발, 치료법, 치료제, [키워드] in silico toxicology adverse effects approval assist carcinogenicity Cardiotoxicity chymotrypsin Compound compounds computational toxicology Consensus Convalescent plasma therapy coronavirus coronavirus disease COVID-19 cysteine cysteine protease drug Drug development effort Endpoint exhibited hepatotoxicity in silico inhibitor inhibitors lead limitations Mutagenicity nucleocapsid protein positive Potential predict predicted prediction profiles protease Regulatory reported Repurposed drugs repurposing SARS-CoV-2 severe adverse effect silico studies therapeutic intervention Toxicity toxicity prediction were assessed were used [DOI] 10.1177/02611929211008196 PMC 바로가기 [Article Type] Article
Remdesivir: A potential game-changer or just a myth? A systematic review and meta-analysis렘데시비르: 잠재적인 게임 체인저인가 아니면 단지 신화인가? 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-01-012022-09-11 Journal: Life sciences [Category] SARS, 치료제, [키워드] 95% CI adverse effects adverse outcome ARDS clinical Clinical improvement clinical recovery Coronavirus-2 Course COVID COVID 19 COVID-19 COVID-19 outbreak discharge rate drug discontinuation Efficacy fixed heterogeneity mechanical ventilation Meta-analysis Mortality Placebo public health Quantitative analysis quantitative synthesis random effect model reduced Remdesivir searched severe adverse effect significantly higher Standard of care systematic review therapeutic efficacy was performed [DOI] 10.1016/j.lfs.2020.118663 PMC 바로가기 [Article Type] Meta-Analysis
Autophagy and SARS-CoV-2 infection: A possible smart targeting of the autophagy pathwayEditorial Published on 2020-06-222022-10-28 Journal: Virulence [Category] COVID-19, MERS, SARS, [키워드] acting activate acute respiratory syndrome administration adverse effect Apoptosis apoptotic death apoptotic pathway approved autophagy autophagy flux Betacoronavirus Cell clinical trials confirmed case coronavirus cross-talk death disrupt drug drug targeting drugs Effect FDA-approved drug infected cell Infection inhibit Macroautophagy molecular mechanism nanomedicine nanoparticle Nanoparticles outbreak overcome pathway powerful tool SARS-CoV-2 SARS-COV-2 infection severe adverse effect Spread suggested Treatment virus virus infection virus replication viruses WHO [DOI] 10.1080/21505594.2020.1780088 PMC 바로가기 [Article Type] Editorial
Effectiveness of convalescent plasma therapy in severe COVID-19 patients중증 코로나19 환자에서 회복기 혈장 요법의 효과530 Published on 2020-04-282022-09-06 Journal: Proceedings of the National Academy of Sciences of [Category] Communicable Disease, COVID-19, SARS, [키워드] Absorption addition Antibody titers antiviral agent Antiviral agents approved C-reactive protein clinical benefit Clinical outcome clinical outcomes clinical symptom Clinical symptoms convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 criteria disappearance Donor dose Endpoint enrolled feasibility FIVE global health Health IMPROVE laboratory parameter Laboratory parameters lung lesion lung lesions lymphocyte Lymphocyte count maintain median time Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Novel coronavirus novel coronavirus disease optimal dose oxyhemoglobin oxyhemoglobin saturation parameter Patient pilot project primary endpoint Radiological examinations randomized trial Seven severe adverse effect severe COVID-19 severe COVID-19 patient Severe patient severe patients Significance significantly supportive care the patient therapy transfused transfusion Treatment Treatment outcome trials undetectable Viral Viral load Viral RNA Viremia [DOI] 10.1073/pnas.2004168117 PMC 바로가기 [Article Type] 530
The early impact of the Covid-19 pandemic on the global and Turkish economyArticle Published on 2020-04-212022-10-29 Journal: Turkish Journal of Medical Sciences [Category] Coronavirus, SARS, [키워드] addition adjust consequence country COVID-19 develop Economy employment Government Health Impact individual Inference material pandemic reaction Result risk severe adverse effect Turkey [DOI] 10.3906/sag-2004-6 PMC 바로가기 [Article Type] Article