Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patientsACE2 발현 조절제의 체계적인 식별은 심근병증을 COVID-19 환자의 사망 위험 인자로 밝혀줍니다Research Published on 2022-01-102022-09-11 Journal: Genome Biology [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression Analysis angiotensin angiotensin-converting enzyme 2 Cardiomyopathy cardiovascular conditions categories characterized Comprehensive condition COVID-19 illness COVID-19 patient COVID-19 patients Critical dataset datasets develop disease drug drug treatment drug treatments drugs Electronic health record Electronic health records enzyme expression Genetic healthy heart HNF1A human tissue identify increased mortality Infection itraconazole joint Mortality overexpression Pathogenesis pathogenesis of COVID-19 Patient perturbations RAD140 receptor Result reveal risk risk factor Risk factors RNA-Seq SARS-CoV-2 SARS-COV-2 infection Seven severe COVID-19 illness supplementary material Transmission upregulation variance while [DOI] 10.1186/s13059-021-02589-4 PMC 바로가기 [Article Type] Research
Disease characteristics and serological responses in patients with differing severity of COVID-19 infection: A longitudinal cohort study in Dhaka, BangladeshCOVID-19 감염의 중증도가 다른 환자의 질병 특성 및 혈청 반응: 방글라데시 다카의 종단 코호트 연구Research Article Published on 2022-01-042022-09-12 Journal: PLoS Neglected Tropical Diseases [Category] 진단, [키워드] addition age age and sex analyzed antibody Antibody Response antibody response against Antibody responses Asymptomatic asymptomatic infection asymptomatic infections biochemical caused Characteristics clinician co-morbid condition co-morbid conditions Community conducted Control COVID-19 COVID-19 disease COVID-19 illness COVID-19 infection CRP CRP level CRP levels D-dimer disease disease severity Disease spectrum elevated enrolled Enrollment evaluate exclusion criteria ferritin ferritin level ferritin levels Follow-up visit follow-up visits Gender geographical region healthy healthy controls help hematological parameter hematological parameters hospital IgG antibodies IgG antibody IgG levels IgM and IgG immunological parameter immunological parameters infected individual Infection levels of antibody longitudinal cohort study longitudinal study lymphocyte lymphocyte counts male many cases Mild Mild disease moderate neutrophil neutrophil count NLR normal range Older age onset of symptom outcome outcomes participant Patient patients patients with COVID-19 predict progression RBD Receptor binding domain responsible risk factor Risk factors SARS-CoV-2 serological response seropositive Severe case severe cases severe COVID-19 disease severe COVID-19 illness severe disease severe disease manifestation severe patients severity of COVID-19 significantly higher Spike protein spike protein of SARS-CoV-2 the disease the spike protein Viral load [DOI] 10.1371/journal.pntd.0010102 PMC 바로가기 [Article Type] Research Article
A Quality Improvement Project to Minimize COVID-19 Infections in Patients Receiving Haemodialysis and the Role of Routine Surveillance Using Nose and Throat Swabs for SARS-CoV-2 rRT-PCR and Serum Antibody Testing혈액투석을 받는 환자의 COVID-19 감염을 최소화하기 위한 품질 개선 프로젝트와 SARS-CoV-2 rRT-PCR 및 혈청 항체 검사를 위한 코 및 인후 면봉을 사용한 일상적인 감시의 역할Article Published on 2022-01-012022-09-11 Journal: Nephron [Category] SARS, 진단, 치료기술, [키워드] antibodies antibody Antibody Response Antibody testing Asymptomatic Bundle COVID-19 COVID-19 illness COVID-19-related death defined detectable diagnosed eliminated evaluated events First wave Haemodialysis Hospitalization implementation improvement incidence infected with COVID-19 Infection prevention Infection prevention control measures Longevity measure methodology Mortality MOST nose outbreak Outbreaks outcome pandemic Patient patients PCR test pre-symptomatic Primary outcomes proportion Quality Quality improvement receiving reduction in role routine rRT-PCR rRT-PCR test SARS-CoV-2 SARS-CoV-2 antibody secondary Secondary outcomes serum antibodies serum antibody severe COVID-19 illness Surveillance Testing Throat utility [DOI] 10.1159/000520654 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection among hospitalised pregnant women and impact of different viral strains on COVID-19 severity in Italy: a national prospective population-based cohort study입원한 임산부의 SARS-CoV-2 감염과 이탈리아의 COVID-19 심각도에 대한 다양한 바이러스 균주의 영향: 국가 전향적 인구 기반 코호트 연구Article Published on 2022-01-012022-09-11 Journal: BJOG : an international journal of obstetrics and [Category] SARS, 변종, [키워드] 95% CI Admission age Asymptomatic Birth rate citizenship clinician Cohort Cohort studies Comorbidity country COVID-19 COVID-19 disease COVID-19 illness COVID-19 pneumonia COVID-19 severity death described Hospital admission hospitalised hospitals ICU ICU admission intensive care intensive care unit Italian Italy Maternal maternal age Migration mode multivariate analyses National Neonatal Neonatal Mortality obesity Occurrence outcome outcomes Pneumonia population-based cohort Pregnancy pregnant women Preterm birth prospective cohort study remained reported required Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral severe COVID-19 disease severe COVID-19 illness severity significant increase Stillbirth strain ventilatory support viral strain virus variant virus variants wild-type women [DOI] 10.1111/1471-0528.16980 PMC 바로가기 [Article Type] Article
COVID-19-associated subacute invasive pulmonary aspergillosisCOVID-19 관련 아급성 침습성 폐 아스페르길루스증Article Published on 2022-01-012022-09-12 Journal: Mycoses [Category] 진단, [키워드] age All the patient Aspergillus change collected complication of COVID-19 COVID-19 Culture described diabetes Diabetic differential diagnosis follow-up period form fungal Fungal infection hospital IgG indolent invasive Lung disease lung lesion Patient patients patients died PCR Pneumonia polymerase chain positive predominant respiratory sample serum severe COVID-19 illness steroid subacute invasive pulmonary aspergillosis. Symptom treated while [DOI] 10.1111/myc.13369 PMC 바로가기 [Article Type] Article
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 자가항체 반응의 역설적인 성별 특정 패턴Research Published on 2021-12-302022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 진단, 치료법, [키워드] AABs absence Activation acute response age analyses antibody Antigen antigens assigned asymptomatic infection autoantibody autoantigen Autoantigen selectivity Autoimmune Autoimmune disease Autoimmune diseases autoreactivity blood draw breadth classic clinical disease Clustering Cohort collected COVID-19 COVID-19 illness demographic data effective intervention effective interventions Evidence evidence of exhibit extreme greater healthy control homology Immune-mediated inflammatory activity lead men men and women modulating molecular multivariable analyses nucleocapsid protein number of symptom participant presence or absence Prevalence reactivity reported symptom reported symptoms Result SARS-CoV-2 SARS-COV-2 infection serological severe COVID-19 illness Sex difference sex differences socio-demographic supplementary material susceptibility Symptom symptomatic infection Symptoms trajectory triggered within 6 months women [DOI] 10.1186/s12967-021-03184-8 PMC 바로가기 [Article Type] Research
Epidemiological Characteristics of Hospitalized Patients with Moderate versus Severe COVID-19 Infection: A Retrospective Cohort Single Centre StudyArticle Published on 2021-12-232022-11-01 Journal: Diseases [Category] COVID-19, [키워드] age Analysis ARDS average C-reactive protein CDC Clinical characteristics clinical factor Clinical outcome clinical outcomes Comorbidity conducted COVID-19 COVID-19 severity CRP D-dimer Demographic factors elevated epidemiological Epidemiological factors Factor Factors fatality FIVE Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients identify intensive care Intervention Laboratory Laboratory parameters LDH majority male management marker mechanical ventilation moderate Mortality NIV non-invasive ventilation non-severe patient noticeable difference Older Oman Patient prevalent progression reduce resource Respiratory disease retrospective cohort study SARS-CoV-2 selected Sepsis severe COVID-19 illness Severe patient severity single-center steroid syndrome therapeutic therapeutic intervention WBC were assessed white cell with COVID-19 [DOI] 10.3390/diseases10010001 PMC 바로가기 [Article Type] Article
Longitudinal SARS-CoV-2 mRNA Vaccine-Induced Humoral Immune Responses in Patients with Cancer암 환자의 세로 SARS-CoV-2 mRNA 백신 유도 체액 면역 반응Article Published on 2021-12-152022-09-11 Journal: Cancer research [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike antibody antibody levels Antibody Response B-cell BNT162b2 booster booster vaccination booster vaccinations Breakthrough infection breakthrough infections Cancer clinical care coronavirus COVID-19 illness dose elicit evaluated Follow-up Frequency hematologic humoral responses Immune checkpoint inhibitor Immune checkpoint inhibitors immune responses immunogenicity Immunoglobulin implication longitudinal Longitudinal studies malignancies median mRNA mRNA-1273 Patient patient selection patients Patients with cancer peak levels Population prospective cohort study receiving reduced remained respiratory response SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines sequence severe acute respiratory syndrome Coronavirus severe COVID-19 illness Solid solid tumor solid tumors sustained therapeutic trajectory Treatment Tumor tumors vaccination Vaccinations Vaccine vaccine-induced immune response Variation [DOI] 10.1158/0008-5472.CAN-21-3554 PMC 바로가기 [Article Type] Article
Evaluation of the Relationship between Clonal Hematopoiesis and Severe COVID-19 Disease in Rhesus MacaquesConference abstract Published on 2021-11-242022-10-05 Journal: Blood [Category] 변종, [키워드] Acquired advanced age age Analysis Asymptomatic autologous Autopsy BAL benefit Blood clinical manifestation clinical symptom clinically co-morbidities cohort study Concentration Control control group controls COVID-19 COVID-19 disease detectable develop died disease Evidence expand Factor Genes group hallmark Hematopoiesis Human Hyperinflammatory IL-6 IL-6 level IL-8 Infection Inflammation inoculated Laboratory LOF loss of function lung tissue macaque MCP-1 Mild MIP-1b Multiorgan mutant Mutation occur pathophysiological pathophysiology phenotype progenitor cell relationship reported Respiratory failure Respiratory samples rhesus macaque risk risk factor robust Sample size SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA sera severe COVID-19 severe COVID-19 disease severe COVID-19 illness significant difference somatic mutation suggested Symptom TET2 the median therapeutic approaches therapy Vaccine development Viral antigen [DOI] 10.1182/blood-2021-152628 [Article Type] Conference abstract
A Rapid Realist Review of Effective Mental Health Interventions for Individuals with Chronic Physical Health Conditions during the COVID-19 Pandemic Using a Systems-Level Mental Health Promotion FrameworkReview Published on 2021-11-232022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] chronic chronic physical health conditions condition conditions conducted consequence country COVID COVID-19 driver effective Evidence Factor Factors framework Health health condition high risk identify implication include indicated individual Intervention iterative mechanism mechanisms mental health mental health interventions mental health promotion outbreak outcome physical promotion provided Public health response Rapid rapid realist review reported Research Resilience review severe COVID-19 illness social isolation threat Topic were used [DOI] 10.3390/ijerph182312292 PMC 바로가기 [Article Type] Review