Optimized Antibiotic Management of Critically Ill Patients with Severe Pneumonia Following Multiplex Polymerase Chain Reaction Testing: A Prospective Clinical Exploratory TrialBrief Report Published on 2024-01-102024-09-05 Journal: Antibiotics [Category] update2024, [키워드] antibiotic management Antimicrobial stewardship Critically ill FilmArray Pneumonia molecular testing severe pneumonia [DOI] 10.3390/antibiotics13010067 PMC 바로가기 [Article Type] Brief Report
Investigation of etiology of community-acquired pneumonia in hospitalized patients in a tertiary hospital of São Paulo City, BrazilOriginal Article Published on 2023-11-132024-09-05 Journal: The Brazilian Journal of Infectious Diseases [Category] update2024, [키워드] Brazil community-acquired pneumonia etiology multiplex polymerase chain reaction severe pneumonia [DOI] 10.1016/j.bjid.2023.103690 PMC 바로가기 [Article Type] Original Article
Patterns of physical activity and SARS-CoV-2 severe pneumonia: A case–control studyOriginal Article Published on 2023-05-092024-09-05 Journal: Medicina clínica [Category] update2024, [키워드] COVID-19 Neumonía severa Patrón de actividad física Physical activity pattern SARS-CoV-2 severe pneumonia [DOI] 10.1016/j.medcli.2023.04.031 PMC 바로가기 [Article Type] Original Article
Reduction in the COVID-19 pneumonia case fatality rate by silver nanoparticles: A randomized case studyResearch Article Published on 2023-03-112024-09-05 Journal: Heliyon [Category] update2024, [키워드] AgNPs AgNPs, Silver Nanoparticles COVID-19 Mortality severe pneumonia Silver nanoparticles Supplemental oxygenation [DOI] 10.1016/j.heliyon.2023.e14419 PMC 바로가기 [Article Type] Research Article
Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
Clinical characteristics of the delta variant of COVID-19 in Jingmen, ChinaArticle Published on 2022-09-232022-11-16 Journal: Medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome age analyzed C-reactive protein Characteristics children China chronic disease clinical Clinical characteristics contagious coronavirus disease Coronavirus-2 cough COVID-19 delta variant diagnosed effective elevated enrolled eosinophil Epidemic epidemiological female Fever granulocyte had no headache infected with SARS-CoV-2 interquartile range lockdown Loss of Smell lung lymphocyte majority male measure mild pneumonia mild symptoms neutrophil count no symptom pathogenicity Patient Pneumonia reported SARS-CoV-2 severe pneumonia significantly the median the SARS-CoV-2 variant virus [DOI] 10.1097/MD.0000000000030812 PMC 바로가기
Patients with infectious diseases undergoing mechanical ventilation in the intensive care unit have better prognosis after receiving metagenomic next-generation sequencing assayResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 비임상, [키워드] 28-day mortality Analysis analyzed approaches assays assigned baseline Concordance Culture diagnostic evaluate Health hypertension ICU Immunosuppressed independent risk factor Infectious disease intensive care intensive care unit mechanical ventilation medical record metagenomic Metagenomic next-generation sequencing Mortality Next-generation sequencing objective on mechanical ventilation pathogen Pathogens diagnosis Patient polymerase chain Prognosis prognosis of patient receiving reducing Result severe pneumonia single-center the patient traditional methods [DOI] 10.1016/j.ijid.2022.07.062 [Article Type] Research article
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and COVID-19: The Clinical Course and Prognosis of 15 Patients From a Tertiary Care CenterArticle Published on 2022-09-012022-11-15 Journal: Journal of clinical rheumatology : practical reports on rheumatic & [Category] 바이오마커, 진단, [키워드] age alveolar center clinical Clinical finding coronavirus disease COVID-19 COVID-19 pandemic cytoplasmic Deceased Diagnosis died Disease activity evaluate Factor glomerular filtration rate glucocorticoid hemorrhage Hospital admission Hospitalized Hypogammaglobulinemia IgG incidence rates Inpatient intensive care Laboratory medical records Mortality organ damage outcome Patient Prognosis renal severe pneumonia symptomatic Tertiary the disease the patient treatment history Vasculitis were recorded were used with COVID-19 [DOI] 10.1097/RHU.0000000000001855 PMC 바로가기
Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into CellsArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Affect Alter analyzed bind binding Cell cells cellular entry coronavirus CoV CoVs Effect Efficiency expressing Genetic polymorphism glycoprotein HEK293T cell host cell membrane host susceptibility Human human ACE2 human Angiotensin-converting enzyme humans Infection Interaction investigated negatively affected plasma membrane Plasmid polymorphism previous study pseudotyped Pseudotyped viruses RBD RBD of SARS-CoV-2 Receptor binding domain relative infectivity reported S protein SARS CoV SARS-CoV SARS-CoV-2 severe pneumonia significantly Single nucleotide variant SNPs SNV SNVs Spike protein stomatitis Substitution suggested Support susceptibility the binding affinity the S protein the SARS-CoV-2 thought transfected with variants of concern viral entry viral surface virus virus entry virus infection viruses were infected wild-type [DOI] 10.1128/spectrum.00870-22 PMC 바로가기
JAK inhibition as a new treatment strategy for patients with COVID-19Review article Published on 2022-08-012022-10-05 Journal: Biochemical pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, [키워드] AAK1 ACE-2 acute respiratory syndrome adverse outcomes angiotensin-converting enzyme 2 Bacterial infection blockers caused clinical trial clinical trials Combination coronavirus coronavirus disease Corticosteroids Course COVID-19 Critical cytokine Cytokine storm Cytokines Cytokines storm develop discharge Disease progression dysregulated effective Epidemic Future GAK greater herpes zoster Host ICU admission IL-2 IL-6 IL-6 receptor immune improve clinical outcome increased risk Infection Inflammation inhibit inhibiting involved Jak JAK inhibition JAK inhibitor Jak-STAT JAK/STAT JAK/STAT signaling janus medication medications Mortality MOST new treatment strategy offer pathway Patient patients with COVID-19 pro-inflammatory cytokine raised regulate released SARS-CoV-2 severe pneumonia significantly Spread Thromboembolic events TNF-α Transcription transmembrane protein Treatment upregulated viral endocytosis virus virus infection WHO guideline [DOI] 10.1016/j.bcp.2022.115162 [Article Type] Review article