Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primatesINO-4800 및 INO-4802를 사용한 프라임-부스트 백신 요법은 비인간 영장류에서 SARS-CoV-2에 대한 면역 반응을 증대 및 확대합니다.Article Published on 2022-05-092022-09-11 Journal: Vaccine [Category] Coronavirus, COVID19(2023년), SARS, 변종, 비임상, [키워드] ACE2 Antibody Response Antibody responses blocking activity Booster vaccine booster vaccines characterized clinical evaluation COVID-19 DNA DNA vaccine Electroporation evaluated expansion homologous or heterologous immune evasion immune response Immunity immunogenicity INO-4800 Intradermal macaque natural infection Neutralizing pandemic portion question regimen regimens rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 variant SARS-CoV-2 variants shifting Strains Support T cell T cells These data Transmissibility vaccination Vaccine variant variants of concern wild-type SARS-CoV-2 Wuhan-Hu-1 [DOI] 10.1016/j.vaccine.2022.03.060 PMC 바로가기 [Article Type] Article
Adenovirus 5 Vectors Expressing SARS-CoV-2 ProteinsSARS-CoV-2 단백질을 발현하는 아데노바이러스 5 벡터Article Published on 2022-04-272022-09-11 Journal: mSphere [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Adenovirus animal model animal models causative agent caused Cell cell line cell lines cellular Community coronavirus coronavirus protein COVID-19 COVID-19 pandemic effort Engagement etiology evaluate Evolution Express expressed facilitate flexibility fusion host cell immune system evasion mechanism molecular Molecular biology N protein Novel coronavirus Nsp12 Nsp7 NSP8 Outbreaks pandemic qRT-PCR Quantitative reagent reagents Receptor binding domain Research researcher resource reverse transcriptase Rules of engagement SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 proteins shifting subcellular localization targets the N protein the S protein the SARS-CoV-2 to be done transcriptase variant variants variety vector Viral proteins Viral vector viral vectors virus Virus-host interaction Virus-host interactions western blotting [DOI] 10.1128/msphere.00998-21 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Lineage Tracking, and Evolving Trends Seen during Three Consecutive Peaks of Infection in Delhi, India: a Clinico-Genomic StudySARS-CoV-2 혈통 추적 및 인도 델리에서 3개의 연속 감염 피크 동안 관찰된 진화 추세: 임상-유전체 연구Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] added amplified B.1.617.2 can not Care caused circulating clade Clinical characteristics co-morbidity collected Community Course COVID-19 COVID-19 in Delhi COVID-19 tracking Delhi detect difference driven by enrolled Genome genome surveillance genomic Genomic surveillance Health Health care help Immune escape India Infection investigated less Lineage lineage tracking lineages Local median morbidity Mutation mutation type mutation types novel lineage pandemic peak processed provide reported SARS-CoV-2 SARS-CoV-2 lineages SARS-CoV-2 variants Sequencing shifting Spread subset Surveillance the patient trajectory Transmissibility trend Vaccines variant variants Variation virus widespread [DOI] 10.1128/spectrum.02729-21 PMC 바로가기 [Article Type] Article
The impact of shifting demographics, variants of concern and vaccination on outcomes during the first 3 COVID-19 waves in Alberta and Ontario: a retrospective cohort study알버타와 온타리오에서 처음 3번의 COVID-19 파동 동안 인구 통계학적 변화, 우려의 변형 및 백신 접종이 결과에 미치는 영향: 후향적 코호트 연구Article Published on 2022-04-262022-09-11 Journal: CMAJ open [Category] COVID19(2023년), SARS, 변종, [키워드] 30-Day mortality 95% CI 95% confidence interval adjusted odds ratio age all-cause hospitalization Alpha Alpha variant anticipated Canada Care Chain Reaction changes in Charlson Comorbidity Index Comorbidities Comorbidity conducted COVID-19 data set death delta variant demographics disease expression examined genomic Health Health care Health care system higher risk Hospital stay Hospitalization Hospitalized individual infected with SARS-CoV-2 Infection lower mortality risk median outcome pandemic Patient phenotype Phenotypes polymerase chain polymerase chain reaction positive result retrospective cohort study reverse transcription SARS-CoV-2 SARS-COV-2 infection Sex shift shifting vaccination Vaccination Status variant variants variants of concern Wave Waves were infected wild-type SARS-CoV-2 younger patient younger patients [DOI] 10.9778/cmajo.20210323 PMC 바로가기 [Article Type] Article
The SGLT2 inhibitor canagliflozin in heart failure: the CHIEF-HF remote, patient-centered randomized trialRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: Nature Medicine [Category] Fulltext, MERS, 임상, 진단, [키워드] 95% confidence interval benefit city clinical trial clinical trials conducted diabete diabetes double-blind trial Effect Ejection fraction heart failure IMPROVE inhibitor Interaction pandemic participant Patient Placebo preserved Primary outcome Randomized randomized trial reduced score shifting significantly Sponsor Symptom symptom burden the primary endpoint Total Trial TSS unblinding [DOI] 10.1038/s41591-022-01703-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
A novel approach for DDoS attacks detection in COVID-19 scenario for small entrepreneursResearch article Published on 2022-04-012022-10-05 Journal: Technological Forecasting and Social Change [Category] 치료기술, [키워드] Accuracy approach attack attacks COVID-19 DDoS Entropy Flash crowd highlight identify lack machine learning measure mechanism problem Research resource resources restrict shifting Small entrepreneurs statistical subject suggested while [DOI] 10.1016/j.techfore.2022.121554 [Article Type] Research article
COVID-MTL: Multitask learning with Shift3D and random-weighted loss for COVID-19 diagnosis and severity assessmentResearch article Published on 2022-04-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] 3D CNNs accelerate Accuracy Algorithm assist AUC automated Chest CT scans CNN complementary component computer tomography COVID-19 COVID-19 diagnosis CT scan deep learning Diagnosis distribution effective feature IMPROVE joint lung mechanism Multitask learning nucleic acid test Prevent radiology severity Severity assessment severity of COVID-19 shifting significantly tested transfer volumetric [DOI] 10.1016/j.patcog.2021.108499 [Article Type] Research article
Social media to enhance engagement and science dissemination during in-person and virtual medical conferences: the SCMR 2020 and 2021 experiences: a report of the SCMR social media task forceReview Published on 2022-03-072022-10-30 Journal: Journal of Cardiovascular Magnetic Resonance [Category] Coronavirus, MERS, SARS, [키워드] adopted Cardiac imaging Cardiac MRI cardiovascular Community Conference coronavirus disease COVID-19 COVID-19 pandemic dissemination education employment ENhance Evolution healthcare highlight Influencers media MOST pandemic professional resonance SCMR shifting social media Society triggered Twitter [DOI] 10.1186/s12968-021-00837-x PMC 바로가기 [Article Type] Review
Omicron Variant of SARS-CoV-2 Virus: In Silico Evaluation of the Possible Impact on People Affected by Diabetes MellitusSARS-CoV-2 바이러스의 오미크론 변종: 당뇨병의 영향을 받는 사람들에게 미칠 수 있는 영향에 대한 실리코 평가Article Published on 2022-03-072022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 receptor ACE2 ACE2 receptor affected Analysis approach asparagine B.1.1.529 binding cause Cell Characteristics computational analysis COVID-19 COVID-19 disease demonstration diabete diabetes Diabetes Mellitus entry routes evidenced feature finding Glycation higher affinity human ACE2 receptor human ACE2 receptor. Impact in silico Interaction interactivity lysine Maillard reaction maintain mechanism molecular Molecular mechanics mutant mutate Mutation omicron Omicron variant outcome Pathways RBD Receptor-binding domain residue risk SARS-CoV-2 severity shift shifting spike Spike protein surface area the disease the receptor-binding domain variant variant of SARS-CoV-2 virus virus attack wild-type [DOI] 10.3389/fendo.2022.847993 PMC 바로가기 [Article Type] Article
Unexpected benefits of and lessons learned from shifting to virtual focus group discussions in the BEECON trialResearch Note Published on 2022-03-042022-10-27 Journal: BMC Research Notes [Category] Coronavirus, MERS, SARS, [키워드] activity benefit COVID-19 pandemic focus Focus groups group group discussion highlight Hispanic hygiene objective oral health parent qualitative data reduced Research researcher Result shifting subject Trial Virtual data collection [DOI] 10.1186/s13104-022-05950-3 PMC 바로가기 [Article Type] Research Note