COVID-19 patient fibrinogen produces dense clots with altered polymerization kinetics, partially explained by increased sialic acidArticle Published on 2022-12-012023-07-10 Journal: Journal of thrombosis and haemostasis : JTH [Category] COVID19(2023년), [키워드] Coagulopathy COVID-19 fibrinogen sialic acid thrombosis [DOI] 10.1111/jth.15882 PMC 바로가기
Chemically Modified Bovine β-Lactoglobulin as a Broad-Spectrum Influenza Virus Entry Inhibitor with the Potential to Combat Influenza OutbreaksArticle Published on 2022-09-162022-11-15 Journal: Viruses [Category] SARS, 신종인플루엔자, 진단, 치료제, [키워드] acute respiratory syndrome administration binds bovine bovine β-lactoglobulin broad-spectrum charged residues chemical modification combat coronavirus effective Efficacy highly pathogenic HIV host cells HPV Human immunodeficiency virus human papillomavirus in vitro in vivo Infection infections Influenza influenza A influenza A virus influenza vaccines Influenza virus inhibiting inhibitor intranasal lack mice outbreak Outbreaks Potential Prevent prevention Prophylactic SARS-CoV-2 sialic acid subunit the receptor-binding domain viral entry viral entry inhibitor. viruses [DOI] 10.3390/v14092055 PMC 바로가기
Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody ReactivityArticle Published on 2022-09-092022-11-15 Journal: ACS Infectious Diseases [Category] SARS, 진단, [키워드] acid antibody antibody reactivity carbohydrate cells Chinese hamster conserved defined domain embryonic kidney cell ENhance evaluated exhibited fucose generate glycoepitope glycoproteomics IgG less mammalian cells mass spectrometry modulated monosaccharides N-linked glycans Neutralizing antibodies produced Protein RBD reactivity Receptor binding domain reduced removal SARS-CoV-2 SARS-CoV-2 positive patients serum sample sialic acid Spike protein Structure the RBD the RBD protein the SARS-CoV-2 vaccine candidates Viral proteins [DOI] 10.1021/acsinfecdis.2c00155 PMC 바로가기
Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions Research Published on 2022-07-132022-10-05 Journal: Nature Communications [Category] 변종, [키워드] assumed binding cell line contribute heterogeneity high affinity host adaptation human receptors IAV in vivo influenza A virus Interaction less non-binding Pandemics pathway provided receptor receptors secreted sialic acid Spanish flu specificity These cells viruses zoonotic [DOI] 10.1038/s41467-022-31840-0 [Article Type] Research
Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligandsArticle Published on 2022-07-122023-06-01 Journal: Biochemical and Biophysical Research Communication [Category] 두창, 수두, 홍역, [키워드] Cis-ligand entry receptor sialic acid Siglec-7 Varicella-Zoster Virus [DOI] 10.1016/j.bbrc.2022.04.111
Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein BSiglec-7은 글리코프로틴 B와 결합하여 수두-대상포진 바이러스 감염을 매개합니다.Article Published on 2022-06-042023-05-31 Journal: Biochemical and Biophysical Research Communication [Category] 대상포진, 두창, 수두, 홍역, [키워드] entry receptor hematopoietic cells sialic acid Siglec-7 Varicella-Zoster Virus [DOI] 10.1016/j.bbrc.2022.03.060
Altered IgG glycosylation at COVID-19 diagnosis predicts disease severityCOVID-19 진단 시 변경된 IgG 글리코실화는 질병 중증도를 예측합니다Article Published on 2022-06-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] Activation agalactosylation Altered analyzed appear asialylation. association Biomarker Blood breadth circulating Coverage COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 pathogenesis COVID-19 patient deficiency demonstrated Diagnosis disease disease course disease severity galactose glycan glycosylation IFN-γ IgG IgG Fc IgG Fc glycosylation IgGs immune activation immune response immune responses Immunity Immunoglobulin immunoglobulins indicate individual induce Inflammation N-glycan NK cell NK cells Pathogenesis Patient patients predict Predictive pro-inflammatory SARS-CoV-2 sialic acid Structure TNF-α Vaccine Variation variations with COVID-19 [DOI] 10.1002/eji.202149491 PMC 바로가기 [Article Type] Article
Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021-22 Northern Hemisphere influenza season2021-22 북반구 인플루엔자 시즌을 계속 지배하는 H3N2 변이체의 항원 및 바이러스 특성Article Published on 2022-05-312022-09-11 Journal: Cell Reports [Category] 변종, [키워드] Alter antibodies antibody antigenic antigenic mismatch binding COVID-19 pandemic CP: Microbiology elicited glycosylation site H3N2 H3N2 strain hemagglutinin Hemisphere human airway cells human cell human cells Influenza influenza vaccine Influenza virus influenza viruses maintain Microbiology neutralize population immunity replicate sialic acid Substitution These data these viruses Vaccine vaccine strain variant Virological virus [DOI] 10.1016/j.celrep.2022.110897 PMC 바로가기 [Article Type] Article
Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 강력한 억제제로서의 다가 9-O-아세틸화-시알산 글리코클러스터Article Published on 2022-05-102022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor Anti-viral atomic bind binding Cell develop event Factor glycans Host host cell Infection inhibition Inhibition assays inhibitor Microscopy moderate molecular multivalent Perspective receptor residues SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sialic acid therapeutic purpose therapeutic purposes Topology Treatment virus while [DOI] 10.1038/s41467-022-30313-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Attacks in the Brain: Focus on the SialomeReview Published on 2022-04-262023-07-09 Journal: Cells [Category] COVID19(2023년), [키워드] Brain COVID-19 Inflammation neurons SARS-CoV-2 sialic acid [DOI] 10.3390/cells11091458 PMC 바로가기 [Article Type] Review