SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like propertiesSARS-CoV-2 스파이크 S1 소단위체는 신경염증, 소교세포 및 행동병 반응을 유도합니다: PAMP 유사 특성의 증거Article Published on 2022-02-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated Activation Anxiety avoidance Brain brain region brain regions CAGE CD11b CD200R1 cells characterized CNS cognitive CXCL1 cytokine signaling demonstrated Depression Direct direct viral infection Evidence evidence of examined function Gene Expression GFAp HEK293 HEK293 cells HMGB1 Hypothesis IFNγ IL-10 IL-1β IL-2 IL-6 IL1B in vitro include independent independent of induce Infection Inflammatory injected male mechanism MHCII microglia microglial modulated Neuroinflammation neurological Neuropsychiatric NLRP3 PAMP PAMPs pathogen pathogen-associated molecular Pattern recognition pattern recognition receptor Protein protein level protein levels receptor signaling reduced S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein Sickness Sickness behavior spike Spike protein structural protein structural proteins Symptom the S1 subunit the SARS-CoV-2 TLR TLR. TLR2 TLR4 TNF transgenic Treatment vehicle viral infection [DOI] 10.1016/j.bbi.2021.12.007 PMC 바로가기 [Article Type] Article
Satisfaction with life and psychological distress during the COVID-19 pandemic: An Egyptian online cross-sectional studyOriginal Research Published on 2022-01-312022-10-28 Journal: African Journal of Primary Health Care & Family Me [Category] Coronavirus, SARS, [키워드] adjusted odds ratio AOR Arabic being conducted Coronavirus disease 2019 COVID-19 COVID-19 pandemic cross-sectional distress Effect Egypt Evidence female highlight Impact independent predictor Intervention life Life satisfaction Mental mental illness moderate pandemic Prevalence promote provide Psychological distress Psychological well-being Result Satisfaction scale setting Sickness were measured [DOI] 10.4102/phcfm.v14i1.2896 PMC 바로가기 [Article Type] Original Research
Serial-Multiple Mediation of Job Burnout and Fatigue in the Relationship Between Sickness Presenteeism and Productivity Loss in Nurses: A Multicenter Cross-Sectional StudyPublic Health Published on 2022-01-142022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, SARS, [키워드] accounted Affect Analysis analysis of variance association average Burnout carried caused Chalder Fatigue Scale China Chinese Cluster COVID-19 pandemic Cross-sectional studies cross-sectional survey Effect exhibited fatigue Hierarchical hospital incidence include independent-samples t -test inventory job Loss mechanism mediation Mediation analysis mental health multicenter Nurse Nurses Patient Pearson correlation physical positively correlated Presenteeism Prevalence productivity promote questionnaire relationship returned scale Sickness Stanford statistically significant total effect variable was used were measured [DOI] 10.3389/fpubh.2021.812737 PMC 바로가기 [Article Type] Public Health
Machine learning approaches in Covid-19 severity risk prediction in MoroccoResearch Published on 2022-01-062022-10-30 Journal: Journal of Big Data [Category] COVID-19, [키워드] Accuracy AdaBoost Admission Algorithm approach approximation assist C-reactive protein Characteristics COVID-19 COVID-19 positive patient COVID-19 severity COVID-19 test D-dimer Data analysis develop Feature reduction Feature selection forest hospital Illness severity machine machine learning machine learning classifier Manifold Morocco patient data patients with COVID-19 Platelets predict prognostic projection reduction Research risk ROC Curve sensitivity severity severity of COVID-19 shown Sickness specificity therapeutic purpose topological data analysis UMAP Uniform were used Zaid [DOI] 10.1186/s40537-021-00557-0 PMC 바로가기 [Article Type] Research
Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illnessResearch Published on 2022-01-062022-10-30 Journal: Journal of Neuroinflammation [Category] COVID-19, [키워드] addition administration Analysis animal model anti-inflammatory actions anti-inflammatory effect Anti-viral behavioural Blood Brain circulating leukocytes CNS collected COVID-19 CXCL1 CXCL10 cytokine production DMSO evaluated evidenced examined Exogenous expression had no host response IFN-γ immunohistochemistry immunomodulatory effects increased expression induce Inflammation Inflammatory response inhibit inhibiting injection Intravenous injection liver lung marker mice nafamostat pathology phenotype provide qPCR reduce reducing restored Result robust serine protease inhibitor shown Sickness Sickness behaviour significantly ssRNA suppressed systemic inflammation temperature TLR7/8 TMPRSS2 TNF Treatment treatment for COVID-19 turn viral cell viral infection virus virus infection was determined [DOI] 10.1186/s12974-021-02357-y PMC 바로가기 [Article Type] Research
Clinical Sensitivity, Specificity and Epidemiology of SARS-CoV-2 Serological Testing Using the Biozek COVID-19 TestArticle Published on 2021-12-282022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Analysis analyzed clinical COVID-19 COVID-19 cases COVID-19 test discrepancy Epidemiology excluded Final Hospitalized hospitalized patient IgG IgM IgM and IgG independent variable Loss of Smell mild case Model multivariable analysis multivariable logistic regression negative controls non-COVID-19 cases Odds ratio P -value Positive test remained Result SARS-CoV-2 sensitivity Sensitivity and specificity sera Sickness specificity Symptom symptomatic Test Testing validation [DOI] 10.3390/diagnostics12010060 PMC 바로가기 [Article Type] Article
Nitric Oxide: The Missing Factor in COVID-19 Severity? †산화질소: COVID-19 심각도에서 누락된 요소? †Hypothesis Published on 2021-12-232022-09-10 Journal: Medical Sciences [Category] SARS, 변종, [키워드] Comorbidities Comorbidity conditions contagious coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptom COVID-19 symptoms delta variant Depletion etiology Factor Hospitalization Hypothesis identify Infectious disease Intervention missing new strain Nitrate nitric oxide NO outcome Patient precursor respiratory respiratory tract SARS-CoV-2 Scientific community Sickness Spread Symptom transmission rates variant vascular disease widespread with COVID-19 [DOI] 10.3390/medsci10010003 PMC 바로가기 [Article Type] Hypothesis
Parents’ Decisions to Vaccinate Children against COVID-19: A Scoping ReviewReview Published on 2021-12-142022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acceptance activities children coronavirus COVID-19 COVID-19 pandemic COVID-19 virus death decision displaying Factor Factors Government Health heterogeneous hospitalizations impacted IMPROVE IQR measure parent parents PROTECT recommendation review scoping review Sickness Side effect the median Transmission vaccinate vaccination vaccination rate Vaccine hesitancy widespread Willingness [DOI] 10.3390/vaccines9121476 PMC 바로가기 [Article Type] Review
Bioactive Molecules Derived from Snake Venoms with Therapeutic Potential for the Treatment of Thrombo-Cardiovascular Disorders Associated with COVID-19COVID-19와 관련된 혈전-심혈관 질환 치료를 위한 치료 가능성을 지닌 뱀 독에서 추출한 생리활성 분자Review Published on 2021-12-012022-09-11 Journal: The protein journal [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Algae Anti-inflammatory Anticoagulant antimicrobial antiplatelet Antiplatelet peptides Antithrombotic Antithrombotic compounds Antiviral antiviral proteins antiviral strategy Bioactivity Biotherapeutics Coagulopathy Compound compounds coronavirus coronavirus disease COVID-19 cytokine Cytokine storm effective Endothelial dysfunction expected genetic difference genetic differences IMPROVE induce Infection Inflammatory responses management mechanism molecule Nature offer pandemic peptide peptides plant platelet hyperactivation Potential Protein respiratory response SARS-CoV-2 SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Sickness snake Snake venom Snake Venoms Snake venoms. therapeutic Therapeutics thrombosis thrombotic disorder thrombotic disorders variant variants Venom Viral viral respiratory with COVID-19 [DOI] 10.1007/s10930-021-10019-4 PMC 바로가기 [Article Type] Review
COVID-19 transmission during swimming-related activities: a rapid systematic reviewResearch Published on 2021-10-292022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] activities activity Analysis association Compliance conducted coronavirus COVID-19 COVID-19 pandemic COVID-19 transmission database Effect Efficacy Efficacy and safety eligibility eligible Evidence Guidance hygiene information management mitigating strategy non-randomized study Personal protective equipment platform Prevent prevention of COVID-19 public health raising Recreation Research Result searched Sickness social distancing supplementary material Swimming systematic review team Transmission vaccination Ventilation [DOI] 10.1186/s12879-021-06802-4 PMC 바로가기 [Article Type] Research