Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in miceArticle Published on 2022-11-012022-11-15 Journal: Inflammation research : official journal of the Eu [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alleviate Analysis Anti-inflammatory anti-inflammatory property anti-inflammatory response ARDS CFZ Clofazimine coronavirus disease COVID-19 Critical decrease disease Diseases distress down-regulate histological change hyperimmune response IL-1β immune IMPROVE increasingly Infectious disease Inflammatory information inhibit involved lipopolysaccharide LPS lung Lung injury Macrophage macrophages mechanism mice Molecular biology pathway pharmacological mechanism potential molecular profile proliferation protective effect Protein protein expression Proteomic analysis proteomics Pulmonary edema Quantitative Signal transduction Signaling significantly survival rate syndrome therapeutic strategy TNF-α [DOI] 10.1007/s00011-022-01623-w PMC 바로가기
The pH Robustness of Bacterial SensingArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] 유전자 메커니즘, [키워드] analyzed appear Bacteria Bacterial bacterial adaptation binding can be used change chaperone chemoreceptor chemotaxis condition conditions COVID-19 pandemic cytosolic demonstrated demonstration determine dimeric domain eight energy Escherichia coli extreme facilitate form Hormones in vivo include information intrinsic isothermal titration calorimetry Ligand ligands mechanism MONITOR Neurotransmitters nine pathway periplasmic pH pH robustness pH value progression Protein Proteins Pseudomonas aeruginosa quorum-sensing receptors recognize reported Research resonance respond response reveal robustness sensing sensor domains signal Signal transduction Signaling TAR tested ultracentrifugation was obtained [DOI] 10.1128/mbio.01650-22 PMC 바로가기
Could Endogenous Glucocorticoids Influence SARS-CoV-2 Infectivity?Article Published on 2022-09-212022-11-15 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect alteration analogues Antiviral component conformational coronavirus coronavirus diseases cortisol COVID-19 Deleterious Dexamethasone endogenous enzyme glucocorticoid Glucocorticoids groups Host Immunological disorders Infection influence inhibit SARS-CoV-2 Innate immunity Interaction mechanism outcome pathogen produced PROTECT Protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signal transduction spike Spike protein stimulate subunit surface protein target cells variant [DOI] 10.3390/cells11192955 PMC 바로가기
Treatment of COVID-19-induced refractory status epilepticus by tocilizumab토실리주맙에 의한 COVID-19 유발 불응성 간질 지속 상태의 치료Case Reports Published on 2022-09-012022-09-12 Journal: European journal of neurology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome block caused coronavirus correlated COVID-19 COVID-19 infection disease IL-6 IL-6 inhibitor immune system increasingly Infection Infectious disease inhibitor of IL-6 interleukin 6 nervous system Neurological complication Patient receptors reported SARS-CoV-2 Seizure Seizures severity of symptoms Signal transduction status epilepticus symptomatic the cytokine storm Tocilizumab Treatment treatment with tocilizumab Unverricht-Lundborg disease [DOI] 10.1111/ene.15440 PMC 바로가기 [Article Type] Case Reports
Highlights of clinical and laboratory parameters among severe COVID-19 patients treated with tocilizumab: a retrospective observational studyArticle Published on 2022-09-012022-11-15 Journal: São Paulo medical journal = Revista paulista de medicina [Category] 진단, 치료기술, [키워드] Admission age Analysis analyzed C-reactive protein (CRP Chest Clinical characteristics Comparative conducted Coronavirus disease 2019 COVID-19 COVID-19 patient CRP CRP level CRS Cytokine release syndrome database died disease evaluate ferritin high mortality hospital Hospitalized IL-6 independent risk factor information interleukin-6 laboratory parameter Logistic regression analysis lymphocyte Mortality neutrophil no difference oxygen saturation Patient performed receiving Research retrospective severe COVID-19 patient Signal transduction significantly lower suppresse survival group survived the patient Tocilizumab tocilizumab administration treated Treatment Turkey WBC White blood cell [DOI] 10.1590/1516-3180.2021.0604.R1.23112021 PMC 바로가기
In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈Article Published on 2022-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics up-regulated USP18 viral infectious disease [DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease Research Published on 2022-08-162022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] accompanied alteration arise Cell cellular ciliary detect dysfunction environmental factors Gene Expression Genetic hedgehog impairment inhibition mitochondrial dysfunction morphology mouse model neurodegenerative disorder neurons observé overactive Parkinson’s disease pathological mechanism pathway patients phenotype precursor required SHH Signal transduction Signaling single-cell therapy transcriptomics [DOI] 10.1038/s41467-022-32229-9 [Article Type] Research
Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent mannerArticle Published on 2022-08-122022-10-06 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome antiviral therapy attenuate catalytic component components contribute Coronavirus-2 COVID-19 Critical cysteine demonstrated Deubiquitination disease severity domain DUB dysregulated Effect Efficiency exhibited greater IFN IFN response independent inhibit inhibitory activity inhibitory effect innate immune interferon IRF3 IκBα MAVS mechanism mechanisms mutant Papain-like protease PLPro protease receptor reduced reported required residue response responses RIG-I RLR signaling SARS-CoV SARS-CoV-2 SARS-CoV-2 pathogenesis Sendai virus Signal transduction Signaling signaling pathway significantly specificity suppressed target TBK1 TRAF3 Traf6 [DOI] 10.3389/fimmu.2022.947272 PMC 바로가기 [Article Type] Article
Lp-PLA2 as a biomarker and its possible associations with SARS-CoV-2 infection바이오마커로서의 Lp-PLA2 및 SARS-CoV-2 감염과의 가능한 연관성Review Published on 2022-07-012022-09-11 Journal: Biomarkers in Medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] affected association Biomarker Biomarkers cardiovascular condition cardiovascular conditions chromosome chronic obstructive chronic obstructive pulmonary disease COVID-19 Economy enzyme estimation Evidence Exercise Tolerance healthy individuals help hepatic disease hour Inflammation life Lp-PLA2 management marker metabolic condition metabolic conditions obstructive pulmonary disease oxidative stress pathophysiological Pathways PLA2G7 pulmonary disease renal impairment risk SARS-COV-2 infection Serum level serum levels Sickness Signal transduction Tolerance Treatment [DOI] 10.2217/bmm-2021-1129 PMC 바로가기 [Article Type] Review
Circularized fluorescent nanodiscs for probing protein-lipid interactions단백질-지질 상호작용을 조사하기 위한 원형 형광 나노디스크Article Published on 2022-05-262022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] binding biochemical events fluorescent fusion peptide GFP HIV-1 intensity Interaction involved membrane neurotransmission peptides Protein Reactions Research respond robust SARS-CoV-2 Signal transduction signaling pathways synaptotagmin synuclein translational transmembrane [DOI] 10.1038/s42003-022-03443-4 PMC 바로가기 [Article Type] Article