Clinical and Virological Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern: A Retrospective Cohort Study Comparing B.1.1.7 (Alpha), B.1.351 (Beta), and B.1.617.2 (Delta)중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변이의 임상 및 바이러스학적 특징: B.1.1.7(알파), B.1.351(베타) 및 B.1.617.2(베타)를 비교한 후향적 코호트 연구( 델타)Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% confidence interval adjusted odds ratio Admission age age and sex analyzed B.1.1.7 B.1.351 B.1.617.2 Beta Chain Reaction clinical clinical outcomes Cohort Comorbidities coronavirus 2 COVID-19 Ct value Ct values cycle threshold death Delta disease severity higher odd higher odds implementation Infection intensive care intensive care unit admission median not seen outcome oxygen Oxygen requirement Patient patients Pneumonia polymerase chain polymerase chain reaction respiratory Retrospective study SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severity severity of illness Sex significantly lower Singapore study period surveillance data vaccination Vaccination Status variants variants of concern viral shedding VoC VOCs were infected wild-type wild-type strain [DOI] 10.1093/cid/ciab721 PMC 바로가기 [Article Type] Article
Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age5~11세 어린이의 오미크론에 대한 BNT162b2 백신의 효과Article Published on 2022-08-112022-10-30 Journal: The New England Journal of Medicine [Category] COVID-19, COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis analyzed Antigen B.1.1.529 B.1.617.2 BNT162b2 children conducted coronavirus coronavirus disease Coronavirus disease 2019 dominant variant Effectiveness first dose Hospitalization incidence incidence rate of BNT162b2 omicron Omicron variant on children outcomes PCR assay PCR-confirmed Poisson regression polymerase predominant rate ratio reduced replaced reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections second dose severe acute respiratory syndrome Coronavirus Singapore Spread vaccination Vaccine variant was used Year [DOI] 10.1056/NEJMoa2203209 PMC 바로가기 [Article Type] Article
Investigating Linkages Between Spatiotemporal Patterns of the COVID-19 Delta Variant and Public Health Interventions in Southeast Asia: Prospective Space-Time Scan Statistical Analysis MethodCOVID-19 델타 변이의 시공간 패턴과 동남아시아의 공중 보건 개입 간의 연관성 조사: 전향적 시공간 스캔 통계 분석 방법Article Published on 2022-08-092022-09-11 Journal: JMIR Public Health and Surveillance [Category] SARS, 변종, 치료기술, [키워드] adopted aligned Analysis analyzed Asia assistance benefit Cluster Clusters collected Continuous continuous surveillance country COVID-19 COVID-19 transmission cumulative Delta delta variant effective Effectiveness Epidemic exacerbate heterogeneity identify increase in Indonesia infection risk Intervention linkage Malaysia measure NPI outbreak pattern progression Propagation Prospective Public public health authorities public health authority Public health intervention reducing Relative risk risk risk of COVID-19 SEA shown Singapore Southeast Asia space-time scan. spatiotemporal Surveillance Transmission Variation variations [DOI] 10.2196/35840 PMC 바로가기 [Article Type] Article
A multidisciplinary effort to increase COVID-19 vaccination among the older adults노년층의 코로나19 예방접종 확대를 위한 다학제적 노력Article Published on 2022-08-012022-09-11 Journal: Frontiers in Public Health [Category] 변종, [키워드] addressed Adults adverse effect analyzed approach case study clinics Cluster Community COVE COVID-19 COVID-19 vaccination COVID-19 vaccine Data analysis dose effort elderly expressed facilitated healthcare worker Healthcare workers implementation information initiated Intention morbidity and mortality multidisciplinary team Older older adult Phase 1 Phase I primary care reduce reported risk of infection significantly Singapore SMS the vaccine vaccinate vaccination vaccination appointment vaccination appointments Vaccination program Vaccine Vaccine hesitancy vaccine promotion variants of concern Volunteer [DOI] 10.3389/fpubh.2022.904161 PMC 바로가기 [Article Type] Article
Analysis of COVID-19 Incidence and Severity Among Adults Vaccinated With 2-Dose mRNA COVID-19 or Inactivated SARS-CoV-2 Vaccines With and Without Boosters in SingaporeArticle Published on 2022-08-012022-11-16 Journal: JAMA Network Open [Category] SARS, 변종, [키워드] 95% CI adjusted Against age Assessing BBIBP-CorV BNT162b2 booster cohort study Combination combinations CoronaVac COVID-19 COVID-19 vaccination death defined determine dose Effectiveness eligible Estimated greater homologous inactivated individual Infection intensive care Moderna mRNA mRNA COVID-19 vaccine mRNA vaccine mRNA-1273 no significant difference Older omicron outcome Pfizer-BioNTech provided reduction Reinfection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 variant severe COVID-19 severe disease Sex Singapore Sinopharm Sinovac supplemental oxygen time interval vaccination Vaccine vaccine dose waned was determined were excluded women [DOI] 10.1001/jamanetworkopen.2022.28900 PMC 바로가기
Estimation of timing of infection from longitudinal SARS-CoV-2 viral load data: mathematical modelling study종적 SARS-CoV-2 바이러스 부하 데이터에서 감염 시기 추정: 수학적 모델링 연구Article Published on 2022-07-282022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] analyzed applied approach border control caused Combination confirmed cases Contact Contact trace Contact tracing country COVID-19 COVID-19 epidemic demonstration estimation high accuracy Infection initial interview Local local infection mathematical model Mathematical modelling mitigate MOST Multiple onset of symptoms Outbreaks Prevent recall bia recall bias reported risk SARS-CoV-2 SARS-CoV-2 viral load secondary transmission Singapore suggested the timing Travel variant variants Viral load were infected Wuhan [DOI] 10.1186/s12879-022-07646-2 PMC 바로가기 [Article Type] Article
Applying the RE-AIM framework to evaluate a holistic caregiver-centric hospital-to-home programme: a feasibility study on Carer MattersArticle Published on 2022-07-192022-10-05 Journal: BMC health services research [Category] 임상, [키워드] addressed adopted adoption affecting Applying approach Care Caregiver caregiver burden Caregiver stress Caregiving clinician collected Community condition conducted Course courses disease ecosystem effective emotional enrolled evaluate family feasibility Feasibility study highlight hospital implementation Implementation science initial involved Isolation knowledge maintenance majority matter Nurses Older pandemic Person Person-centered care. Perspective Prolonged provided qualitative data Quantitative data recipients recruitment reduced reported resource resources screened Singapore Stress Support was collected were given [DOI] 10.1186/s12913-022-08317-3 PMC 바로가기 [Article Type] Article
The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies수용체 결합 도메인 결합 특이적 인간 단일클론 항체를 사용하여 바이러스에 감염된 세포에서 SARS-CoV-2 스파이크 단백질의 세포 특성화Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adopted antibody appearance appears attachment B cell B cells biological properties biological property can be used Cell cell-to-cell transmission characterization conformation conformational change convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient convalescent patient serum Convalescent patients cytoplasmic demonstrated early stage early stages electron microscopy epitope Epitopes Evidence exhibited FIVE focus furin future therapeutic Golgi complex host cell Human human monoclonal antibodies Human monoclonal antibody immunofluorescence microscopy immunological indicated infected cells infected with SARS-CoV-2 Infection Interaction isolate isolates Microscopy mitigate MONITOR monoclonal new virus occur offer Protein provided RBD reagent Receptor binding domain receptor binding domain (RBD) recognize required S protein S protein cleavage S protein RBD SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-CoV-2 spike SARS-CoV-2-infected cell SARS-CoV-2-infected cells Singapore Specific spike staining the RBD the S protein therapeutic These data Transmission Vaccine variant virus infection virus particles virus-infected cell virus-infected cells was used were used while [DOI] 10.1128/jvi.00455-22 PMC 바로가기 [Article Type] Article
Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trialClinical Trial Published on 2022-07-082022-10-05 Journal: The Lancet. Respiratory Medicine [Category] 임상, 진단, 치료법, [키워드] 1:1 addition adverse event Analysis assigned baseline Cohort Complete COVID-19 cumulative defined double-blind Europe extracorporeal membrane oxygenation finding Follow-up funding hazard ratio hospital discharge hospitalised hypothesised IMPROVE incidence infused intravenous Invasive mechanical ventilation investigators modified intention-to-treat monoclonal antibody combination Mortality neutralising NIH occurred operation Organ failure outcome participant Patient Phase 3 phase 3 trial Placebo placebo group placebo-controlled trial Primary outcome randomised Randomly receive receiving Registered Remdesivir renal replacement therapy Result Safe seronegative Singapore speed standard care study drug Study participants Support sustained Symptom the placebo group therapy Treatment Uganda USA were excluded with COVID-19 [DOI] 10.1016/S2213-2600(22)00215-6 [Article Type] Clinical Trial
First cases of infection with the 21L/BA.2 Omicron variant in Marseille, France프랑스 마르세유에서 21L/BA.2 오미크론 변종 첫 감염 사례Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitution amino acid substitutions Clinical outcome Cluster country deletions Denmark deviation diagnosed distribution emergence England facilitate flattening France Genome genomes incidence Infection initial Interaction Marseille MONITOR N-terminal domain Nepal Next-generation sequencing nucleotide nucleotide substitution nucleotide substitutions omicron Omicron variant Phylogeny predominant qPCR remained resulting SARS-CoV-2 Singapore South Africa southern France Spike protein Surveillance the spike protein Travel variant viral genome viral genomes [DOI] 10.1002/jmv.27695 PMC 바로가기 [Article Type] Article