Phylogenetic and full-length genome mutation analysis of SARS-CoV-2 in Indonesia prior to COVID-19 vaccination program in 2021Research Published on 2021-11-212022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] Analysis COVID-19 COVID-19 pandemic COVID-19 vaccination D614G mutation database described epidemiological full-length genome genome analysis genomics study GISAID Health Indonesia initiative isolate isolates Mutation observé outbreak Phylogeny President Result S protein SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates single mutation Spike protein spread of COVID-19 supplementary material Surveillance Transmission Vaccine virus was used Wuhan, China [DOI] 10.1186/s42269-021-00657-0 PMC 바로가기 [Article Type] Research
In depth analysis of Cyprus-specific mutations of SARS-CoV-2 strains using computational approaches계산 접근법을 사용하여 SARS-COV-2 균주의 키프로스-특이 적 돌연변이의 깊이 분석Research Published on 2021-11-132022-09-10 Journal: BMC Genomic Data [Category] MERS, SARS, 변종, [키워드] Alter Amino acid Analysis appear association can not changes in computational approach Computational approaches conformational change Course Cyprus-specific mutations death depth analysis Frequency generate genetic data GISAID indication information lead Linear regression Linear regression model linear regression models Mutation National nucleotide nucleotide position ORF1ab gene pandemic Prevalence prevalent Protein protein structure public health Regression model regression models Result SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 strain SARS-CoV-2 strains selective sequence significantly single mutation specific mutations statistical analysis Structural prediction supplementary material the SARS-CoV-2 unique Viral viral pathogenicity Viral virulence [DOI] 10.1186/s12863-021-01007-9 PMC 바로가기 [Article Type] Research
Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity선택된 SARS-CoV-2 신흥 변이체에 대한 단일 돌연변이의 기여는 항원성을 증가시킵니다.Article Published on 2021-11-012022-09-11 Journal: Virology [Category] SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor antigenicity binding contribute coronavirus COVID-19 D614G variant decrease demonstrated Efficacy facilitate Interaction modulated observation observé Off-rate Pathogenesis phenotype Protein RBD SARS-CoV-2 selected single mutant single mutation single mutations spike spike glycoproteins Spike protein spikes temperature tested the Spike Transmissibility Transmission Vaccine vaccine efficacy Vaccines variant variants variants of concern variants of concern. variants of interest VOCs VOIs Wuhan-Hu-1 [DOI] 10.1016/j.virol.2021.09.001 PMC 바로가기 [Article Type] Article
Real-time quantification of the transmission advantage associated with a single mutation in pathogen genomes: a case study on the D614G substitution of SARS-CoV-2병원체 게놈에서의 단일 돌연변이와 관련된 전달 유리의 실시간 정량화 : SARS-COV-2의 D614G 치환에 대한 사례 연구Research Published on 2021-10-072022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 변종, 치료기술, [키워드] activity approach COVID-19 COVID-19 pandemic D614G D614G substitution demonstrated detect disease disease control dominance epidemiological Evidence evidence of Evolution generate global health Health increase molecular Mutation outcome pathogen quantification Real-time estimation reported Reproduction number Result SARS-CoV-2 SARS-CoV-2 genomes single mutation statistical framework Statistical modelling supplementary material surveillance data threat Transmissibility Transmission Transmission advantage USA [DOI] 10.1186/s12879-021-06729-w PMC 바로가기 [Article Type] Research
GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2GB-2가 ACE2와 야생형 사이의 상호작용을 차단하고 SARS-CoV-2의 스파이크 단백질 돌연변이Article Published on 2021-10-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] (+)-Catechin (Pubchem CID: 9064) ACE2 B.1.351 Beta Beta variant binding can not catechin clinical study confirmed case conformational change coronavirus disease Coronavirus disease 2019 dose-dependent manner E484K E484K mutation Epsilon Epsilon variant flavin GB-2 Glycyrrhiza uralensis Health Organization induce Infection inhibit inhibited Interaction K417N L452R Lineage monoclonal antibodies multiple mutation multiple mutations Mutation N501Y Neutralizing activity Neutralizing antibodies neutralizing antibody outbreak Prophylaxis RBD Receptor binding domain reduced reported resistance to neutralizing antibodies SARS-CoV-2 SARS-CoV-2 variant single mutation spike Spike protein Temple the disease the RBD the spike protein theaflavin Theaflavin (Pubchem CID: 135403798) Theaflavin 3-gallate (Pubchem CID: 136825044). Tian Transmissibility variant variants wild type wild-type World Health Organization Wuhan Wuhan, China [DOI] 10.1016/j.biopha.2021.112011 PMC 바로가기 [Article Type] Article
In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2remdesivir 저항의 시험 관내 선택 SARS-COV-2의 진화 적 예측 가능성을 시사한다.Research Article Published on 2021-09-172022-08-13 Journal: PLoS Pathogens [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] absence accumulation acting Affect animal model animal models Antiviral antiviral drug approved Author backbone changes in characterisation circulating SARS-CoV-2 variant Clinical management conserved coronavirus COVID-19 patients displaying drug-resistant EIDD2801 Evidence evidence of excess FDA FDA approval Frequency genetics immune immune pressure immune selection implication in vitro indicate low frequency morbidity and mortality mutants Mutation no evidence of not affect Nsp12 nucleoside occurred overcome passage patients polymerase Population predicted provide RDV Remdesivir replication advantage residue resistant mutants responsible risk RNA virus RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants selected sensitivity Sequencing single mutation small molecule Substitution substitutions Surveillance the SARS-CoV-2 genome Transmission Treatment treatment of COVID-19 patients variants of concern Viral viral replication virus virus viruses widespread worldwide pandemic [DOI] 10.1371/journal.ppat.1009929 PMC 바로가기 [Article Type] Research Article
Computational design of SARS-CoV-2 peptide binders with better predicted binding affinities than human ACE2 receptorArticle Published on 2021-08-022022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] ACE2 angiotensin-converting enzyme 2 approach bind binding binding affinity candidate coronavirus COVID-19 COVID-19 pandemic domain human ACE2 receptor human cells inhibit inhibitors Interaction molecular dynamics Mutation peptide peptides predicted Protein design receptor Receptor binding domain reported residue S1 subunit SARS-CoV-2 SARS-CoV-2-RBD single mutation stability suggested therapeutic α1 helix [DOI] 10.1038/s41598-021-94873-3 PMC 바로가기 [Article Type] Article
Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2Article Published on 2021-06-292022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] acute respiratory distress acute respiratory syndrome CCL11 CCL17 CCL19 CCL20 CCL21 CCL22 CCL25 CCL26 CCL27 chemokine clade clades conserved coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CXCL9 cytokine elevated Evidence examined expression expressions functional high mortality human population IFNβ IL-10 IL-1α IL-1β IL-23 IL-4 IL-6 IL-7 IL-8 Inflammation Inflammatory cytokine modulate N protein NF-κB NF-κB activation NF-κB signaling ORF3a orf3a gene ORF7a orf7a protein Proinflammatory cytokine proinflammatory cytokines provide SARS-CoV-2 sequence significantly single mutation syndrome TNF-α upregulated variants Viral host response Viral proteins [DOI] 10.1038/s41598-021-92941-2 PMC 바로가기 [Article Type] Article
Inferring the Association between the Risk of COVID-19 Case Fatality and N501Y Substitution in SARS-CoV-2COVID-19 사례 사망 위험과 SARS-CoV-2의 N501Y 대체 간의 연관성 추론Article Published on 2021-04-082022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, [키워드] activity approach B.1.1.7 lineage case fatality case fatality ratio CFR changes in Clinical outcome COVID-19 COVID-19 mortality Evidence evidence of example fatality global health gradually increased Health healthcare illustration instantaneous molecular MONITOR mortality risk Mutation N501Y N501Y substitution pandemic public health reconstructed risk SARS-CoV-2 SARS-CoV-2 genomes significantly single mutation statistical framework Statistical modelling statistically significant Substitution surveillance data the SARS-CoV-2 United Kingdom variant variants [DOI] 10.3390/v13040638 PMC 바로가기 [Article Type] Article
Genomic Evidence of In-Flight Transmission of SARS-CoV-2 Despite Predeparture TestingSynopsis Published on 2021-03-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus disease acute respiratory syndrome analyzed coronavirus coronavirus disease country COVID-19 Disease progression Dubai evidence of First wave genomic data in-flight transmission Infection information instance Isolation mandatory New New Zealand positive quarantine required respiratory infections SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 transmission severe acute respiratory syndrome coronavirus 2 single mutation Testing undergo United Arab Emirates virus viruses zoonoses [DOI] 10.3201/eid2703.204714 PMC 바로가기 [Article Type] Synopsis