mTOR-Inhibition and COVID-19 in Kidney Transplant Recipients: Focus on Pulmonary FibrosisPharmacology Published on 2021-08-232022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Allograft antiviral properties cardiovascular disease Comorbidity COVID-19 diabetes drugs evaluated Everolimus focus high risk Immunosuppression Interaction kidney transplant recipient Kidney transplantation mitigate mTOR-inhibitors Patient pharmacological progression proliferation pulmonary pulmonary fibrosis pulmonary toxicity recipient reduce reduction risk SARS-CoV-2 SARS-CoV-2 infected patient severe COVID-19 severe disease Sirolimus T lymphocyte the cytokine storm therapeutic potential therapeutic strategy Transplant Treg with COVID-19 [DOI] 10.3389/fphar.2021.710543 PMC 바로가기 [Article Type] Pharmacology
Sirolimus in a Renal Transplant Recipient Infected With COVID-19: A Blessing in Disguise?Infectious Disease Published on 2021-08-112022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome adverse outcomes Antiviral Chemotherapy Chronic kidney disease coronavirus Coronavirus infection COVID-19 COVID19 Diabetes Mellitus higher risk hypertension immune system Immunocompromised Immunosuppressant inhibiting effect low molecular weight mammalian mTOR inhibitors multiple comorbidity pandemic Patient Probability Rapamycin recipient recovered completely renal Renal transplant SARS-CoV-2 severity Sirolimus steroid the patient Transplant Treatment [DOI] 10.7759/cureus.17102 PMC 바로가기 [Article Type] Infectious Disease
Dermatologic adverse events associated with use of oral mechanistic target of rapamycin inhibitors in a cohort of individuals with tuberous sclerosis complexArticle Published on 2021-07-252024-09-04 Journal: The British journal of dermatology [Category] 대상포진, [키워드] Acne adverse events Everolimus mechanistic target of rapamycin inhibitors oral mTOR inhibitors oral ulcers Side effects Sirolimus systemic mTOR inhibitors Tuberous sclerosis complex [DOI] 10.1111/bjd.19124 PMC 바로가기 [Article Type] Article
Coronavirus Disease 2019 in Kidney Transplant Recipients: Single-Center Experience and Case-Control Study신장 이식 수혜자의 코로나바이러스 질병 2019: 단일 센터 경험 및 사례 통제 연구Article Published on 2021-05-012022-09-11 Journal: Transplantation proceedings [Category] SARS, 치료제, [키워드] age and sex Bacterial infections calcineurin Case fatality rate Case series Clinical course Clinical outcome clinical outcomes comparable Control controls coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed with COVID-19 died drug level exclusion experience fatality Hemodialysis Hospitalized Immunosuppression Infection inhibitor kidney transplant recipients mammalian morbidity morbidity and mortality mTOR no significant difference no significant differences non-transplant patient non-transplant patients outcome pandemic Rapamycin recipient Secondary infection secondary infections single-center Sirolimus tacrolimus Transplant with COVID-19 [DOI] 10.1016/j.transproceed.2021.01.002 PMC 바로가기 [Article Type] Article
Rapamycin: Drug Repurposing in SARS-CoV-2 InfectionReview Published on 2021-03-052022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] addition Analysis antivirals approved article association consequence COVID-19 database drug Drug repurposing Effectiveness Efficiency Final Health Infection involved literature review mTOR inhibitor Mutation peer-reviewed performed Rapamycin reduced repurposing Research SARS-COV-19 SARS-CoV-2 Sirolimus tested therapy vaccination Viral RNA Web of Science with COVID-19 worldwide pandemic [DOI] 10.3390/ph14030217 PMC 바로가기 [Article Type] Review
Applying computer simulations in battling with COVID-19, using pre-analyzed molecular and chemical data to face the pandemicReview article Published on 2020-10-172022-10-05 Journal: Informatics in Medicine Unlocked [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] anti-inflammatory agents antiviral drugs Applying assessment available data clinically Compound Computer simulation Coronavirus disease 2019 COVID-19 creating darunavir docking Drug discovery drugs Effect Efficiency group healthcare service inhibitors Lopinavir Medicines molecular molecular analysis molecular docking Molecular simulation outcome pandemic Patient performed researcher SARS-CoV-2 shown Sirolimus tested the disease Treatment viral entry viral replication with COVID-19 [DOI] 10.1016/j.imu.2020.100458 [Article Type] Review article
Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infectionsResearch Perspective Published on 2020-04-302022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, [키워드] affecting age Betacoronavirus clinical evaluation Comorbidity coronavirus COVID-19 COVID-19 pandemic decrease described disease Diseases Efficacy elderly patients frailty highlight immune function immune system immunosenescence indicate Infection infection rate infection rates infections Intervention investigated limitations loss of function marker medication Older Population previous study rapalog Rapamycin reduce Research responsible SARS-CoV-2 severity Sirolimus the disease therapeutic intervention vaccination while [DOI] 10.18632/aging.102988 PMC 바로가기 [Article Type] Research Perspective
Long-term efficacy and safety of sirolimus therapy in patients with lymphangioleiomyomatosisResearch Published on 2019-08-202024-09-02 Journal: Orphanet Journal of Rare Diseases [Category] 대상포진, [키워드] Lymphangioleiomyomatosis Pulmonary function Sirolimus [DOI] 10.1186/s13023-019-1178-2 PMC 바로가기 [Article Type] Research
Development of Kasabach-Merritt phenomenon following vaccination: More than a coincidence?Article Published on 2018-10-312024-09-02 Journal: The Journal of Dermatology [Category] 백일해, 파상풍, [키워드] kaposiform hemangioendothelioma Kasabach-Merritt phenomenon platelet level Sirolimus vaccination PMC 바로가기
Safety and efficacy of Rapamune® (Sirolimus) in kidney transplant recipients: results of a prospective post-marketing surveillance study in KoreaResearch Article Published on 2018-08-132024-09-02 Journal: BMC Nephrology [Category] 대상포진, [키워드] Kidney transplantation Post-marketing surveillance Sirolimus [DOI] 10.1186/s12882-018-1002-6 PMC 바로가기 [Article Type] Research Article