Anakinra treatment efficacy in reduction of inflammatory biomarkers in COVID-19 patients: A meta-analysisCOVID-19 환자에서 염증성 바이오마커 감소에 대한 아나킨라 치료 효능: 메타 분석Meta-Analysis Published on 2022-06-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute-phase reactant Admission Anakinra analyzed anti-inflammatory agent C-reactive protein C-reactive protein (CRP Care Cochrane Central concentrations conducted COVID-19 COVID-19 patients CRP CRP value CRP values D-dimer database dimer Efficacy elevated ferritin Follow-up hematological Inflammatory Inflammatory biomarker inflammatory biomarkers interleukin interleukin-1 Laboratory males Manger marker mean difference mean value Meta-analysis notable Patient Protein reduce mortality reduced reduction review SARS-CoV-2 serum Serum ferritin SMD statistically the mean Treatment treatment of COVID-19 patients trials Web of Science [DOI] 10.1002/jcla.24434 PMC 바로가기 [Article Type] Meta-Analysis
Role of triggering receptor expressed on myeloid cells-1 (TREM-1) in COVID-19 and other viral pneumonias: a systematic review and meta-analysis of clinical studiesCOVID-19 및 기타 바이러스성 폐렴에서 골수 세포-1(TREM-1)에 발현된 트리거 수용체의 역할: 임상 연구의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-06-012022-09-11 Journal: Inflammopharmacology [Category] MERS, 바이오마커, [키워드] 95% CI analyzed Biomarker clinical study conducted contributing to controls coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Disease progression disease severity Diseases effect size elevated eligible evaluate Evidence expressed expression Google Scholar healthy healthy control healthy controls healthy individuals Human immune response infected patient infected patients Infection infections Inflammatory item marker material Meta-analysis Mild-to-moderate Mortality myeloid cells myeloid cells-1 no differences observational studies observational study outcome Patient patients with COVID-19 performed Pneumonia pneumonias PRISMA pro-inflammatory provided receptor Reporting review role SARS-CoV-2 severe COVID-19 severity shown significantly SMD standardized mean difference subgroup analysis systematic review systematic reviews the disease TREM-1 triggering Viral viral infections Viral pneumonia viral pneumonias viruses was performed were expressed [DOI] 10.1007/s10787-022-00972-6 PMC 바로가기 [Article Type] Meta-Analysis
Effects of COVID-19 Mental Health Interventions Among Children, Adolescents, and Adults Not Quarantined or Undergoing Treatment Due to COVID-19 Infection: A Systematic Review of Randomised Controlled TrialsCOVID-19 감염으로 인해 격리되지 않았거나 치료를 받고 있지 않은 아동, 청소년 및 성인 사이의 COVID-19 정신 건강 개입의 영향: 무작위 대조 시험의 체계적인 검토Article Published on 2022-05-012022-09-11 Journal: Canadian journal of psychiatry. Revue canadienne d [Category] 임상, [키워드] 95% CI 95% confidence interval Anxiety Autoimmune base children Controlled controlled trials coronavirus country COVID-19 COVID-19 infection database Depression depressive symptom Depressive symptoms Effect effective eligible English expressive feasible French General population group therapy heterogeneity high risk hospitalised Infection Internet Intervention Living systematic review mental health mental health interventions not significant nous Older participant Participants Population post-intervention Psychological outcomes psychological outcomes. randomised controlled trial reduced reported review risk of bia searched significantly SMD standardized mean difference Support Swedish Symptom tested the United State therapy Treatment Trial trials United States Worry [DOI] 10.1177/07067437211070648 PMC 바로가기 [Article Type] Article
501Y.V2 spike protein resists the neutralizing antibody in atomistic simulations501Y.V2 스파이크 단백질은 원자 시뮬레이션에서 중화 항체에 저항합니다.Article Published on 2022-04-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 501Y.V2 antibody resistance atomic B.1.351 backbone binding caused CCS changed complex complexes COVID-19 pandemic COVID-19 vaccine design deaths distribution distributions experiment free energy free energy landscape indicated lead molecular molecular dynamics Mutation neutralizing antibody observation outbreak Protein reduced RMSD S protein SARS-CoV-2 SARS-CoV-2 variant significantly SMD SMD simulations spike Spike protein the mean variant wild-type [DOI] 10.1016/j.compbiolchem.2022.107636 PMC 바로가기 [Article Type] Article
High-throughput virtual screening of drug databanks for potential inhibitors of SARS-CoV-2 spike glycoproteinSARS-COV-2 스파이크 당 단백질의 잠재적 억제제에 대한 약물 데이터 뱅크의 고 처리량 가상 스크리닝Article Published on 2022-03-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] ACE2 ADME approved best binding binding energy C terminal caused chidamide complexes Compound COVID-19 docking domain ebastine effort FDA approved drug flexible in silico Approach indacaterol individual inhibitors of SARS-CoV-2 interact Interaction interactions investigated Ligand MD simulation MD simulations molecular molecular dynamics Novel coronavirus performed potential inhibitors protein-ligand protein-ligand interaction recorded regorafenib SARS-CoV-2 silodosin SMD spike glycoprotein Spread stability Steered molecular dynamics subunit target tasosartan the RBD treat Viral viral RBD viral S viral S protein viral spike Virtual screening virus [DOI] 10.1080/07391102.2020.1835721 PMC 바로가기 [Article Type] Article
Low tricuspid annular plane systolic excursion is associated with a poor outcome in patients with COVID-19 A systematic review and meta-analysis낮은 삼첨판 환형 평면 수축기 여행은 COVID-19 환자의 나쁜 결과와 관련이 있습니다. 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-02-252022-09-10 Journal: Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 1.26 95% confidence interval affected age cardiac injury Comorbidities coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 disease Critically ill Critically ill patient critically ill patients diabete diabetes disease severity echocardiography effect size Egger test greater heterogeneity hypertension incidence indicated Injury mean difference Meta-analysis meta-regression modulated no statistically significant difference nonsurvivor nonsurvivors outcome outcomes Patient patients with COVID-19 prognostic publication bias reduced Registered Sex significantly skewed SMD standardized mean difference statistically significant difference subgroup analysis survivor sustained systematic review TAPSE tricuspid tricuspid annular plane systolic excursion utility ventricular dysfunction was performed were used [DOI] 10.1097/MD.0000000000028971 PMC 바로가기 [Article Type] Meta-Analysis
Differential immunogenicity of homologous versus heterologous boost in Ad26.COV2.S vaccine recipientsAd26.COV2.S 백신 수용자에서 동종 대 이종 부스트의 차등 면역원성Article Published on 2022-02-112022-09-11 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Adenovirus Adenovirus Vector Antiviral antiviral immunity BNT162b2 boost breadth cellular immune responses cellular immunity ChAdOx1 ChAdOx1 nCoV-19 college coronavirus disease Coronavirus disease 2019 COV2.S COVID-19 dose ENhance feature Heterologous heterologous immunity heterologous vaccine homologous homologous or heterologous humoral immune responses immunological immunological parameter individual individuals knowledge lack Medical Research Council Ministry of Health mRNA of BNT162b2 offered protection pump quantity recipient second dose Singapore single dose small sample size SMD specific antibodies spike-specific antibodies Spike-specific antibody Support supported T cell T cells Trustee utilization vaccination Vaccine Vaccines [DOI] 10.1016/j.medj.2021.12.004 PMC 바로가기 [Article Type] Article
Platelet-to-lymphocyte ratio, a novel biomarker to predict the severity of COVID-19 patients: A systematic review and meta-analysisOriginal Articles Published on 2022-02-012022-10-29 Journal: Journal of the Intensive Care Society [Category] COVID-19, [키워드] 95%CI Admission Analysis article association Biomarker China conducted coronavirus COVID-19 evaluate identify Inflammatory marker Meta-analysis non-severe group non-severe patients Older participant patients patients with COVID-19 peer-reviewed platelet-to-lymphocyte ratio predict prognostic SARS-CoV-2 Seven severe COVID-19 severe COVID-19 patient severe group severity severity of COVID-19 SMD suggested systematic literature search systematic review underlying disease was done were used [DOI] 10.1177/1751143720969587 PMC 바로가기 [Article Type] Original Articles
Effects of the COVID-19 pandemic on sexual functioning and activity: a systematic review and meta-analysisResearch Published on 2022-01-282022-10-28 Journal: BMC Public Health [Category] COVID-19, SARS, [키워드] activities affected affecting cause China CINAHL Cochrane Library Community confidence interval correlated COVID-19 COVID-19 pandemic difference dimension dysfunction Effect effective evaluate the effect evaluated Evidence Factor female participants Frequency function global pandemic greater heterogeneous identify impacted increase in index individuals majority male participants men Meta-analysis meta-analytical new virus participant Psychological PsycINFO public health measure reduce reduced reduction in reported researcher restriction Result SARS-CoV-2 Sex sexual Sexual functioning and activity SMD Spread statistically significant Stress supplementary material systematic review and meta-analysis viral outbreak was used Web of Science were assessed women Wuhan [DOI] 10.1186/s12889-021-12390-4 PMC 바로가기 [Article Type] Research
Unbinding ligands from SARS-CoV-2 Mpro via umbrella sampling simulationsChemistry Published on 2022-01-262022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] Accuracy Analysis approach ASN142 binding binding affinity correlation coefficient demonstrated experiment free energy Glu166 Gly143 inhibitor Interaction Leu141 Ligand linear mechanism MPro not differ pathway residue SARS-CoV-2 Mpro Small molecule inhibitors SMD Substitution the SARS-CoV-2 umbrella sampling unbinding pathway [DOI] 10.1098/rsos.211480 PMC 바로가기 [Article Type] Chemistry