Evidence of co-infections during Delta and Omicron SARS-CoV-2 variants co-circulation through prospective screening and sequencingArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analysis chimeric circulation Co-infection collected COVID-19 Delta Delta and Omicron VOC Epidemic epidemiologically evidence of France generate Genetic Health Infection K417N L452R Mutation nasopharyngeal sample omicron Pandemics pathogenic patients PCR assay polymorphism primer sets profile Recombination recombination event Respiratory samples S-gene mutation Sample SARS-CoV-2 SARS-CoV-2 co-infection SARS-CoV-2 genome SARS-CoV-2 variant screened sequence Sequencing single nucleotide Single nucleotide polymorphism Single nucleotide polymorphism screening SNP SNPs submitted Surveillance variant virus VoC was performed WGS whole genome Whole genome sequencing [DOI] 10.1016/j.cmi.2022.06.030 PMC 바로가기
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variantsArticle Published on 2022-10-062022-11-16 Journal: Cell Stem Cell [Category] COVID19(2023년), SARS, 변종, [키워드] cause Cell Cluster Dengue dengue virus disease-associated functional variant genome-wide association Genome-wide association study GWAS Human genetics identify indicated individuals Infection iPSC array isogenic hiPSC lines leakage of mtDNA locus Loss mitochondrial mtDNA NDUFA4 non-risk allele polymorphism provide risk risk allele SARS-CoV-2 SARS-COV-2 infection screening strategy sensitivity Signaling single-nucleotide single-nucleotide polymorphism SNP SNPs Stress susceptibility type I interferon upregulation viral infection viral infectivity virus Zika virus ZIKV [DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기
COVID-19 infection and transmission includes complex sequence diversityArticle Published on 2022-09-082022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] allele approach biallelic complex consensus sequence COVID-19 infection COVID-19 pandemic Delta Donor Evolution heterogeneity heterogeneous include Infection infections investigator Lineage majority microbial nucleotide change Occurrence omicron pandemic pathogen Patient polymorphism recipients reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence sequence sequence variation Sequencing significantly SNP tested Transmission Transmission dynamics transmitted variant variants variants of concern viral genome whole genome [DOI] 10.1371/journal.pgen.1010200 PMC 바로가기
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, BrazilArticle Published on 2022-09-052022-11-16 Journal: BioMed Research International [Category] SARS, 변종, 유전자 메커니즘, [키워드] activated allele association Asymptomatic Brazil CARD8 center clinical clinical evolution Clinical management clinical manifestations contributing to COVID-19 COVID-19 severity death disease disease severity Factors Genetic Genetic variant Genotype group Haplotype Host host cells Inflammasome Inpatient investigated knowledge logistic regression models mechanism moderate NLRP3 NLRP3 inflammasome outcomes Patient performed polymorphism Polymorphisms profile protection Real-time PCR recruited Rio de Janeiro risk risk factor SARS-COV-2 infection SARS-CoV-2-infected individual scale severe symptom severity Significant single-nucleotide SNP SNPs Symptom the WHO two group two groups variants virus was determined WHO with mild disease [DOI] 10.1155/2022/9082455 PMC 바로가기
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
Single-Nanoparticle-Based Digital SERS Sensing Platform for the Accurate Quantitative Detection of SARS-CoV-2Article Published on 2022-08-312022-11-15 Journal: ACS applied materials & interfaces [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis Beta buffer Concentration concentrations coronavirus Delta detect detection Digital digital SERS Diseases enzyme-linked immunosorbent Gamma generate HEPES limit of detection mutated Mutation omicron platform Prevent provide quantification Quantitative Raman spectroscopy reporters representing SARS-CoV-2 SARS-CoV-2 variant single-nanoparticle detection SNP Spike protein Spread tailorable SERS nanoprobe. target protein the SARS-CoV-2 variants [DOI] 10.1021/acsami.2c07497 PMC 바로가기
Gene Variants Related to Cardiovascular and Pulmonary Diseases May Correlate with Severe Outcome of COVID-19심혈관 및 폐 질환과 관련된 유전자 변이가 COVID-19의 심각한 결과와 관련될 수 있음Article Published on 2022-08-042022-09-11 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Analysis association cardiovascular cardiovascular diseases Cohort collected correlated COVID-19 COVID-19 patients CVD DRC1 Genetic Genetic variant genetic variants GWAS HADHA identified variant INDEL individual introns nucleotide outcome Poland polymorphism Protective pulmonary pulmonary disease pulmonary diseases risk Risk factors single nucleotide Single nucleotide polymorphism SNP SNPs subset variant variants was performed was used WGS whole-genome sequencing [DOI] 10.3390/ijms23158696 PMC 바로가기 [Article Type] Article
IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19중증 COVID-19 환자의 임상 결과에서 IFNAR2 관련성Article Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] 변종, 치료제, [키워드] amplify Antiviral antiviral response assays association beta receptor Clinical outcome COVID-19 COVID-19 mortality cytokine Cytokines determined by ELISA evaluate Genetic genetic susceptibility Genetic variant genetic variants Hospitalized IFN IFNAR1 IFNAR2 IFNs immunomodulatory activities individual individuals Innate immunity interferon Interferon alpha interferon alpha-beta interferons investigated Mortality mortality risk Non-survivors Patient patients hospitalized plasma sample plasma samples Protein receptor receptors severe COVID-19 severity SNP subject subunit survivor the disease Type type I IFNs variant with COVID-19 [DOI] 10.3389/fimmu.2022.949413 PMC 바로가기 [Article Type] Article
Are Pain Polymorphisms Associated with the Risk and Phenotype of Post-COVID Pain in Previously Hospitalized COVID-19 Survivors?이전에 입원한 COVID-19 생존자의 통증 다형성이 COVID-19 이후 통증의 위험 및 표현형과 관련이 있습니까?Article Published on 2022-07-262022-09-11 Journal: Genes [Category] 변종, [키워드] All participants Anxiety association BDNF carried clinical feature Clinical features cognitive collected COMT COVID-19 de novo depressive distribution distributions Features female Gender Genotype Hospitalization hospitalized COVID-19 HTR1B involved kinesiophobia long-COVID Musculoskeletal neuropathic neuropathic pain no differences no effect not significantly different nucleotide OPRM1 Pain participant Participants participated phenotypic feature phenotypic features polymerase chain reaction polymerase chain reactions polymorphism Post-COVID Psychological risk rs4680 rs6265 selected sensitization single nucleotide Single nucleotide polymorphism sleep quality SNP SNPs survivor Survivors Symptom Symptoms variable variant were assessed [DOI] 10.3390/genes13081336 PMC 바로가기 [Article Type] Article
GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibilityGDF15 및 ACE2는 중증도에 따라 COVID-19 환자를 계층화하는 반면 ACE2 돌연변이는 감염 감수성을 증가시킵니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 characterized circulating Cohort coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient disease disease severity Early detection Effect Frequency GDF15 GDF5 global pandemic growth heterogeneous in vitro Infection Inflammation Mild Mild disease Missense Mutation mutations Patient plasma Prognosis risk factor sensitivity severity severity of COVID-19 SNP SNPs susceptibility uninfected control [DOI] 10.3389/fcimb.2022.942951 PMC 바로가기 [Article Type] Article