solubility – Page 2 – Communicable Diseases Research

Biophysical properties of the isolated spike protein binding helix of human ACE2

인간 ACE2의 분리된 스파이크 단백질 결합 나선의 생물물리학적 특성

Article

Published on 2021-07-202022-09-11
Journal: Biophysical Journal [Category] SARS, 변종, 치료기술,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alanine angiotensin binding binding affinity Concentration coronavirus F28 Factor failure Fluorescence correlation spectroscopy high affinity human ACE2 human Angiotensin-converting enzyme human cell human cells hydrophobic hydrophobic residue hydrophobic residues interact lack much lower mutant oligomerization peptide promoter receptor Receptor-binding domain reduce reduced severe acute respiratory syndrome Coronavirus solubility Spike protein the receptor-binding domain the spike protein viral spike protein virus virus detection without affecting β-sheet
[DOI] 10.1016/j.bpj.2021.06.017 PMC 바로가기 [Article Type] Article

Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2

ORF10 단백질의 주목할만한 서열 상동성은 SARS-CoV-2의 구조를 내부 조사합니다

Article

Published on 2021-06-302022-09-11
Journal: International journal of biological macromolecules [Category] Coronavirus, MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome Amino acid amino acids Analysis antigenicity carried caused change clone coil convalescent patient Convalescent patients coronavirus coronavirus disease COVID-19 CTL cytotoxic T lymphocyte decrease epitope Epitopes expressed Fatality rate homology in silico in vivo Intrinsic disorder lymphocyte MERS Missense mutation Missense mutations Mutation mutations nine Open reading frame ORF10 ORF10 protein pandemic pangolin pangolin-CoV Pangolin-CoV-2020 Pathogenesis pathogenesis of COVID-19 pathology physicochemical predicted Protein Proteins reactive respiratory SARS-CoV SARS-CoV-2 sequence sequence homology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shift similarity solubility stability strand T cell tyrosine unique variant
[DOI] 10.1016/j.ijbiomac.2021.03.199 PMC 바로가기 [Article Type] Article

Role of Hydrogen Bonds in Formation of Co-amorphous Valsartan/Nicotinamide Compositions of High Solubility and Durability with Anti-hypertension and Anti-COVID-19 Potential

항고혈압 및 항-COVID-19 잠재성을 지닌 높은 용해도 및 내구성을 갖는 공동-비정질 발사르탄/니코틴아미드 조성물의 형성에서 수소 결합의 역할

Article

Published on 2021-04-012022-08-31
Journal: Molecular Pharmaceutics [Category] 치료제,

[키워드] (nicotinamide) acting active pharmaceutical ingredient analyses angiotensin Angiotensin II anti-hypertensive applied approaches Bioavailability bond caused characterized co-amorphization conformational change conformational changes coronavirus COVID-19 Density functional theory Donor drug drugs Effects Efficacy exhibit flexible Formation functional heterodimeric hydrogen Hydrogen bond hydrogen bonds hypertension ingredient Interaction key factor liquid low molecular weight lung market molecules NIC nicotinamide pandemic coronavirus Physicochemical properties Potential quantum theory receptor receptor blocker responsible role SARS-COV-2 infection solid dispersion solubility treat valsartan X-ray
[DOI] 10.1021/acs.molpharmaceut.0c01096 PMC 바로가기 [Article Type] Article

Antiplasmodial Combined Formulation of Artemisinin with Peschiera fuchsiaefolia Bis-Indole Alkaloids

article

Published on 2021-01-312024-09-01
Journal: Pathogens [Category] 말라리아,

[키워드] antioxidant complexation Controlled release Drug-combination particles Formulation natural products Oral drug delivery poorly water-soluble drug pre-formulation solubility
[Article Type] article

Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2

신종 코로나바이러스 SARS-CoV 2의 주요 프로테아제인 3-키모트립신 유사 프로테아제(3CLpro)의 생화학적 및 생물물리학적 특성 규명

Article

Published on 2020-12-172022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 치료제,

[키워드] 3CLpro Activation Alter analytical techniques antiviral drug target antiviral therapeutics biochemical Biochemistry Biophysical chemistry buffer buffer solution calculated candidate condition conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Divalent drug enzymatic assay exhibited functional protein highest IMPROVE inhibitor inhibitors ionic strength kinetic lead less liberation maturation Novel coronavirus novel coronavirus disease parameter polyprotein processing protease reduced respiratory responsible salts SARS-CoV 2 SARS-CoV-2 setup Severe acute respiratory syndrome slope solubility stability thermodynamic Viral virus was recorded
[DOI] 10.1038/s41598-020-79357-0 PMC 바로가기 [Article Type] Article

Are Myths and Preconceptions Preventing Us from Applying Ionic Liquid Forms of Antiviral Medicines to the Current Health Crisis?

Perspective

Published on 2020-08-202022-10-29
Journal: International Journal of Molecular Sciences [Category] Coronavirus, MERS,

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride

article

Published on 2018-07-312024-09-01
Journal: Pathogens [Category] 말라리아,

[키워드] Absorption Bioequivalence Biopharmaceutics Classification System (BCS) excipients permeability proguanil hydrochloride Regulatory science solubility
[Article Type] article

Differences in the purification and solution properties of PurC gene products from Streptococcus pneumoniae and Bacillus anthracis

스트렙토코쿠스 뉴모니아와 바실루스 안트라시스의 PurC 유전자 산물의 정제 및 용액 특성 차이

journal-article

Published on 2015-10-012024-08-04
Journal: Protein Expression and Purification [Category] 폐렴구균 감염증,

[키워드] Bacillus anthracis Protein yield PurC Purine biosynthesis solubility Streptococcus pneumoniae
[DOI] 10.1016/j.pep.2015.05.016 [Article Type] journal-article

Efinaconazole Topical Solution, 10%: Formulation Development Program of a New Topical Treatment of Toenail Onychomycosis

에피나코나졸 국소 용액, 10%: 발톱 무좀의 새로운 국소 치료제 개발 프로그램

journal-article

Published on 2015-07-012024-07-28
Journal: Pathogens [Category] 백선증,

[키워드] delivery drug design efinaconazole excipients Formulation Onychomycosis permeability Physicochemical properties solubility stability
[DOI] 10.1002/jps.24459 [Article Type] journal-article

Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice

article

Published on 2015-02-282024-09-01
Journal: International Journal of Nanomedicine [Category] 말라리아,

[키워드] G6PD deficiency in vivo efficacy microemulsion solubility
[Article Type] article