GEOM, energy-annotated molecular conformations for property prediction and molecular generation Research Published on 2022-04-212022-10-05 Journal: Scientific Data [Category] 치료제, [키워드] 3D structure approach assist conformation conformations dataset functional generate machine ML model molecular molecule outperform physical predict property solvent [DOI] 10.1038/s41597-022-01288-4 [Article Type] Research
HYBRiD: hydrogel-reinforced DISCO for clearing mammalian bodiesHYBRiD: 포유류의 몸을 청소하기 위한 하이드로겔 강화 DISCOArticle Published on 2022-04-012022-09-11 Journal: Nature methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] antibody Chest compatibility component components demonstrated dimensions DISCO feature fluorescent hACE2 heterogeneous hybrid immunostaining K18-hACE2 transgenic mice macroscopic mammalian mice nervous system Newborn offer organ organic parvalbumin Protein reporter Research SARS-COV-2 infection solvent three dimensions translational utility Viral viral pathology Visualization [DOI] 10.1038/s41592-022-01427-0 PMC 바로가기 [Article Type] Article
Seasonality and reduced nitric oxide titration dominated ozone increase during COVID-19 lockdown in eastern China Research Published on 2022-03-282022-10-05 Journal: npj Climate and Atmospheric Science [Category] 치료법, [키워드] Analysis atmospheric average China Compound Concentration COVID-19 decrease dominant Emissions Factor increase increase in lockdown nitric oxide NOx Observational data Photochemistry precursor Radiation reduced reduction reduction in Region resulting seasonality solvent Variation VoC VOCs weakened Yangtze River Delta [DOI] 10.1038/s41612-022-00249-3 [Article Type] Research
Building the Momentum for A Stronger Pharmaceutical System in Africa아프리카에서 더 강력한 제약 시스템의 추진력 구축Article Published on 2022-03-112022-08-31 Journal: International Journal of Environmental Research an [Category] MERS, 치료제, [키워드] affected Africa Algeria building complex continent country Coverage COVID-19 COVID-19 pandemic Critical eight had more had no Health Kenya labelling Local Medicines momentum Morocco National Nigeria pharmaceutical pharmaceutical system strengthening. reflect Regulatory scaled solvent South Africa Structure System Vaccine Vaccines [DOI] 10.3390/ijerph19063313 PMC 바로가기 [Article Type] Article
Dimerization of SARS-CoV-2 nucleocapsid protein affects sensitivity of ELISA based diagnostics of COVID-19Research article Published on 2022-03-012022-10-05 Journal: International journal of biological macromolecules [Category] SARS, 진단, [키워드] 95% CI acute respiratory syndrome Affect Antigen antigenicity characterized composed coronavirus COVID-19 COVID-19 diagnosis diagnostic diagnostics dimeric E. coli elevated ELISA enzyme-linked immunosorbent expressed forms highest immunological IMPROVE indicate indicated maintain modelled structure MONITOR monoclonal antibody monomeric N protein N-protein nucleocapsid protein Protein purified robust SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sensitivity Sensitivity and specificity severe acute respiratory syndrome coronavirus 2 solvent stability susceptibility the N protein virus [DOI] 10.1016/j.ijbiomac.2022.01.094 [Article Type] Research article
Interactions of Co, Cu, and non-metal phthalocyanines with external structures of SARS-CoV-2 using docking and molecular dynamicsArticle Published on 2022-02-282022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] Adsorption antagonist approach approaches atomic candidate caused Characteristics characterized Cobalt Computational models Computational neuroscience Computational platforms and environments Contamination contribute copper COVID-19 pandemic deviation docking Dynamics envelope protein Gibbs free energy glycoprotein information inhibitor Interaction lethality rate Ligand macromolecules Masks molecular Molecular docking study molecular dynamics New coronavirus occur predict protease Proteases Protein analysis Protein function predictions provided residue SARS-CoV-2 Software solvent spike Structure structures Virtual drug screening virus were used [DOI] 10.1038/s41598-022-07396-w PMC 바로가기 [Article Type] Article
The Physical Basis for pH Sensitivity in Biomolecular Structure and Function, With Application to the Spike Protein of SARS-CoV-2Molecular Biosciences Published on 2022-02-182022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acquisition application Basis benefit bioinformatics calculate conformation conformational changes Coronaviruses demonstrated effort experimental structure form function functional histidine increasingly Interaction mitigate modulation molecular Molecular dynamics simulation Neutral omicron pH dependence physical predict Protein protein electrostatics question SARS-CoV-2 sensitivity solvent Spike protein Stage Structure structures the Spike the spike protein variant spike variants Variation [DOI] 10.3389/fmolb.2022.834011 PMC 바로가기 [Article Type] Molecular Biosciences
Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptorSARS-CoV-2 Omicron 변이체의 RBD 돌연변이는 인간 ACE2 수용체에 대한 더 강한 결합을 초래합니다Article Published on 2022-01-292022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, [키워드] ACE2 ACE2-RBD Analysis bind binding binding interactions caused complex conducted COVID-19 pandemic death Efficacy ENhance human Ace2 protein human ACE2 receptor hydrogen Infection Interaction molecular dynamics Molecular dynamics simulation Mutation mutations neutralization antibodies Neutralization antibody occurred omicron Omicron mutant Omicron variant pandemic Protein raised RBD RBD of SARS-CoV-2 Receptor binding domain reducing S-protein SARS-CoV-2 SARS-CoV-2 virus solvent spike Spike protein surface area the SARS-CoV-2 virus Tight binding Vaccine variant variants of SARS-CoV-2 [DOI] 10.1016/j.bbrc.2021.12.079 PMC 바로가기 [Article Type] Article
Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complexSARS-COV-2 NSP1–5'-UTR 복합체의 확장 된 앙상블 시뮬레이션Research Article Published on 2022-01-192022-09-10 Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘, [키워드] 5’-untranslated region acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Author bind binding block C-terminal causative pathogen characteristic cluster analysis complex Consistency coronavirus COVID-19 cryo cryo-EM Efficiency electron density ENCODE evade experimental evidence experiments Extended flexible Host host cells host immunity host mRNA human cell increase infected cells interactions intrinsically investigated involved mechanism modulate molecular dynamics Molecular dynamics simulation molecular mechanism mutant N-terminal nonstructural protein 1 nsp1 open pandemic of COVID-19 performed predicted Protein Recognition recognize reported residue residues respiratory ribosome RNA SARS-CoV-1 SARS-CoV-2 SARS-CoV-2-infected cells selective severe acute respiratory syndrome Coronavirus Simulation solvent suggested the SARS-CoV-2 translate translation Viral Viral RNA virus X-ray crystallographic structure [DOI] 10.1371/journal.pcbi.1009804 PMC 바로가기 [Article Type] Research Article
Secondary Structures of the Transmembrane Domain of SARS-CoV-2 Spike Protein in Detergent MicellesArticle Published on 2022-01-182022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] conformation COVID-19 Critical detergent detergent micelles domain form helical structure host cells linker micelle NMR NMR spectroscopy proline Protein Receptor binding Relaxation residue S-protein SARS-CoV-2 secondary secondary structure shown side chain solvent spike Spike protein Structural analysis Structure transmembrane transmembrane domain viral entry viral infectivity [DOI] 10.3390/ijms23031040 PMC 바로가기 [Article Type] Article