Methods for early characterisation of the severity and dynamics of SARS-CoV-2 variants: a population-based time series analysis in South AfricaArticle Published on 2022-10-012022-11-16 Journal: The Lancet. Microbe [Category] COVID19(2023년), SARS, 변종, [키워드] African age agency aggregate analyses Analysis assessment calculate case ascertainment characterisation Characteristics correlation coefficient COVID-19 data-driven death dependent on develop disease severity Effect epidemic wave epidemiological estimate fluctuation Government Hospital admission hospitalisation hospitalisations individual information interval laboratory data Metrics Older Omicron variant pathogen Population provide public health Public health responses reduced reduction in resource responses robust SARS-CoV-2 severity South South Africa Spread surveillance data variant VoC VOCs [DOI] 10.1016/S2666-5247(22)00182-3 PMC 바로가기
COVID-19 in New South Wales children during 2021: severity and clinical spectrumArticle Published on 2022-09-192022-11-16 Journal: The Medical journal of Australia [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI acute respiratory syndrome adjusted odds ratio Admission Admissions age analyses Analysis Asymptomatic Care Childhood diseases children chronic respiratory disease clinical factor cohort study coronavirus coronavirus disease COVID-19 declined delta variant Epidemics Frequency greater Health home care Home care services, hospital-based hospital Hospital admission hospitalised infancy Infants infections Inflammatory intensive care likelihood Local Medical conditions Morbidity. MOST network New outbreak outcome positive Prospective random SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid severity South syndrome Virtual care were recorded wheeze with mild disease [DOI] 10.5694/mja2.51661 PMC 바로가기
SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concernArticle Published on 2022-09-182022-10-06 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] absence ACE2 acute respiratory syndrome ADK antibody BA.2 BA.5 Beta BNT162b2 breadth Breakthrough infection cell line change circulating clade Clinical effect cohorts contributed convalescent convalescent sera coronavirus COVID-19 COVID-19 hospitalisation Delta development disease severity Donor donors dose foundation Future genetic difference greater humoral Humoral response IgG in vitro isolate Lineage lineages Live virus management monitoring monoclonal antibody mortality rates nafamostat nasopharyngeal sample nasopharyngeal swabs neutralisation neutralisation assay Neutralising Antibodies neutralising antibody New observation of BNT162b2 omicron Omicron BA.1 other variant pathway peak plasma potency recorded reduced reduction reduction in Research response responses SARS-CoV-2 sensitivity significantly Sotrovimab South Spread Support supported tested Testing therapeutic Therapies TMPRSS2 TMPRSS2 inhibitor TMPRSS2. Transmission utilised vaccination Vaccine variant viral lineage viral variant [DOI] 10.1016/j.ebiom.2022.104270 PMC 바로가기 [Article Type] Article
IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohortArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] African Anti-inflammatory Antiviral change children clinically Cohort condition conditions Control controls COVID-19 cytokine differential expression differentially expressed gene down-regulated gene expression febrile febrile illness Follow-up Gene Expression healthy healthy children healthy controls highlight IL-27 IL27 immune gene immune-related gene Inflammatory inflammatory condition inflammatory conditions inflammatory reaction innate immune pathway innate immune system investigated Kawasaki disease lack longitudinal MIS-C multisystem inflammatory syndrome. Other pathway Patient pyroptosis quantitative PCR resolved SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity South South Africa specimen syndrome systemic lupus erythematosus timepoints Treatment two group unique up-regulated was determined [DOI] 10.3389/fimmu.2022.992022 PMC 바로가기
Decline in antibody responses to SARS-CoV-2 post-vaccination poses a risk to health care workers예방 접종 후 SARS-CoV-2에 대한 항체 반응 감소는 의료 종사자에게 위험을 초래합니다Article Published on 2022-09-012022-09-11 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 변종, [키워드] Abbreviations: HCW, health care worker Abstract African Antibody Response Care Decline HCW Health Health care Health care worker IGG, immunoglobulin g IGM, immunoglobulin m Immunoglobulin Immunoglobulin G immunoglobulin M interquartile interquartile range IQR IQR, interquartile range lateral flow lateral flow immunoassay LFIA LFIA, lateral flow immunoassay Medical Research Council POC POC, point-of-care product risk SA-MRC, South African Medical Research Council SAHPRA, South African Health Products Authority SARS-CoV-2 South variant VoC VOC, variant of concern. [DOI] 10.1016/j.jinf.2022.06.008 PMC 바로가기 [Article Type] Article
Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approachArticle Published on 2022-09-012022-11-15 Journal: Microbial pathogenesis [Category] SARS, 유전자 메커니즘, 치료제, [키워드] addition African Analysis Antiviral compound antiviral target approach binding energy calculate Cell cellular entry characterized Compound conformational database demonstrated disrupt distribution expressed feature functional In-vitro inhibitory effect Interaction mechanism of action molecular molecular dynamic simulation Molecular dynamics simulation multiple organ natural natural product Neuropilin-1 NRP1 performed pleiotropic Protein recent S-protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 research screened selected South stability surface receptor the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach viral infectivity virtual screening. [DOI] 10.1016/j.micpath.2022.105701 PMC 바로가기
Validation of laboratory developed serology assays for detection of IgG antibody to severe acute respiratory syndrome coronavirus 2 in the South African population남아프리카 인구에서 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 IgG 항체 검출을 위해 실험실에서 개발한 혈청학 분석의 검증Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African antibody approved assays authority Beta characterization circulating collected commercial immunoassay Concordance confirmation continent Control coronavirus country Coverage cross-reactive antibodies cut-off value Delta demonstrated described determine diagnostic differentiation ELISA enzyme IFA IgA IgG IgG antibody IgM immunosorbent Infection infection rate investigated Laboratory Laboratory developed lateral flow limit Local mammalian molecular pandemic Patient persistence Population populations positive positive predictive values Predictive predictive values product Quality assurance resource respiratory RT-PCR RT-PCR positive patient SARS-CoV-2 SARS-CoV-2 spike protein sensitivity Serological assay serological assays serology assay serology assays Serology assays. serum sample serum samples severe acute respiratory syndrome Coronavirus shown small sample size South South Africa specificity Spike protein Surveillance tested Vaccine validation variant [DOI] 10.1016/j.jviromet.2022.114571 PMC 바로가기 [Article Type] Article
Whole-genome sequencing of SARS-CoV-2 reveals diverse mutations in circulating Alpha and Delta variants during the first, second, and third waves of COVID-19 in South Kivu, east of the Democratic Republic of the CongoResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] A.23.1 Analysis B.1.351 B.1.617.2 circulating circulation coding sequence consensus genome COVID-19 D614G Delta delta variant Diagnosis disease severity dominant Genes Genetic evolution Genetic variation genome coverage genomic global pandemic highlight identify include information isolate Lineage management mapped molecular MOST Mutation nucleocapsid protein objective ORF1ab ORF3 outbreak Oxford P.1 pandemic pangolin Phylogenetic analysis Point mutation processed reference genome responsible Result reveal SARS-CoV-2 SARS-CoV-2 isolate sequence sequenced Sequencing Seven South South Kivu subsequent Surveillance synonymous the SARS-CoV-2 genome Treatment variant variants were used whole-genome sequencing Wuhan [DOI] 10.1016/j.ijid.2022.05.041 [Article Type] Research article
Leveraging South African HIV research to define SARS-CoV-2 immunity triggered by sequential variants of concernArticle Published on 2022-09-012022-11-15 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome African antigenic assays B cell cause Combination coronavirus coronavirus disease COVID-19 cross-reactive cross-reactive antibodies driving elicited Epidemic Frequency genomic highlight HIV HIV vaccine hybrid immunity. immune response Immunity immunogenic immunological immunology Infection mutated variants pandemic platform population immunity Prevent Region Research respiratory viruses respond response responses SARS-CoV-2 SARS-CoV-2 immunity shown South Surveillance the SARS-CoV-2 to define triggered vaccination Vaccine variants variants of concern virus VoC [DOI] 10.1111/imr.13086 PMC 바로가기
Contrasting Distribution of SARS-CoV-2 Lineages across Multiple Rounds of Pandemic Waves in West Bengal, the Gateway of East and North-East States of IndiaArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome alteration Amino acid analyzed B.1.617.2 caused Characteristics comprehensive analysis coronavirus coronavirus disease country COVID19 Delta distribution East Epidemiology Evolution gateway genomic variation host miRNA hydrophobicity profile implication India Infection information Lineage miRNA molecular Multiple Mutation North nucleocapsid pandemic pandemic. Predictive profile Region reveal SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 lineage sequencing data South state variant Viral protein Viral transmission viral variant virus genome Wave West West Bengal [DOI] 10.1128/spectrum.00914-22 PMC 바로가기