The changing spectrum of microbial aetiology of respiratory tract infections in hospitalized patients before and during the COVID-19 pandemicArticle Published on 2022-09-302022-11-15 Journal: BMC Infectious Diseases [Category] SARS, 치료기술, [키워드] 95% CI Admission aetiology Bacteria Bacterial Bergen categorical data Cohort cohorts Community community acquired community acquired pneumonia conducted containment measures COVID COVID-19 COVID-19 pandemic declined Electronic health record Epidemiology FilmArray pneumonia panel Fisher Haemophilus influenzae hospital Hospital admission hospitalized patient infection control less Lower respiratory tract Mann-Whitney measure microbial molecular testing outbreak pathogen Patient patients Pneumonia proportion Prospective Study reducing respiratory respiratory tract infection Respiratory tract infections SARS-CoV-2 significantly lower specimens Spread Staphylococcus aureus Streptococcus pneumoniae surveillance data t-test Trust variables virus was used [DOI] 10.1186/s12879-022-07732-5 PMC 바로가기
Platinum nanoparticles (PtNPs)-based CRISPR/Cas12a platform for detection of nucleic acid and protein in clinical samplesArticle Published on 2022-09-082022-11-15 Journal: Analytica chimica acta [Category] SARS, 치료기술, [키워드] acute respiratory syndrome Antigen Biomarker Biomarkers biosensor clinical sample Concentration contagious coronavirus CRISPR/Cas12a detect Detection sensitivity diagnostic Diseases identify N gene Noble metal nanocatalysts nucleic acid Nucleic acid detection optical platform Platinum Protein Protein detection Quantitative reduction reported Research RT-qPCR SARS-CoV-2 sensitivity specificity specimens [DOI] 10.1016/j.aca.2022.340203 PMC 바로가기
Clinical Performance Characteristics of the Swift Normalase Amplicon Panel for Sensitive Recovery of Severe Acute Respiratory Syndrome Coronavirus 2 GenomesArticle Published on 2022-09-012022-11-15 Journal: The Journal of molecular diagnostics : JMD [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome allele frequency Amplicon bases Bioscience clade clinical clinical utility consensus sequence coronavirus coronavirus 2 criteria evaluated Evolution expected Genome genome coverage identity infection control limit of detection median metagenomic sequencing outbreak Panel PCR-negative performance performed positive R 2 respiratory respiratory virus Sanger sequencing SARS-CoV-2 sensitive sequence sequencing method specimen specimens spike gene Transmission variant whole-genome [DOI] 10.1016/j.jmoldx.2022.05.007 PMC 바로가기
Detection of viable SARS-CoV-2 in deep respiratory specimens despite negative nasopharyngeal SARS-CoV-2 RT-PCR: occult COVID-19 as an unsuspected cause of pulmonary infiltrates in immunocompromised patientsCase report Published on 2022-08-232022-10-05 Journal: IDCases [Category] 진단, 치료기술, [키워드] anti-CD20 Antigen Antiviral treatment BAL Bronchoalveolar lavage changes clearance COVID-19 COVID-19 infection demonstrated detection diagnosed Diagnosis etiology highlight Immunocompromise Immunocompromised patient Immunocompromised patients immunohistochemistry invasive Isolation limit lung lung parenchyma lung tissue nasopharyngeal occult Occult COVID-19 pandemic parenchymal Patient persistence Precaution Primary infection Prolonged pulmonary infiltrate Relapse repeated Replication reported resolved respiratory specimen rituximab SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 virus specimens spike-protein suggested Viral antigen viral persistence virus [DOI] 10.1016/j.idcr.2022.e01611 [Article Type] Case report
SARS-CoV-2-reactive IFN-γ-producing CD4 + and CD8 + T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients혈액 내 SARS-CoV-2 반응성 IFN-γ 생성 CD4 + 및 CD8 + T 세포는 백신 접종을 받지 않은 중환자 COVID-19 환자의 임상 중증도와 상관관계가 없습니다Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] anti-RBD Anti-RBD IgG association Biomarker Biomarkers Blood blood levels C-reactive protein CD4 CD8 Clinical outcome Clinical severity comparable Concentration correlation COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients D-dimer Deceased detectable died different time point different time points ELISA Enumeration enzyme enzyme-linked immunosorbent assay examined ferritin flow cytometry greater magnitude IFN-γ IgG level increased mortality interleukin interleukin-6 investigated Kinetics Lactose Lower respiratory tract male median age membrane protein Mortality no correlation Patient patients Peripheral blood predict respiratory RNA loads SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 S sera Serum level serum levels specimens spike Spike protein survived Survivors T cell T cell subset T cells T-cell T-cell Response T-cell responses tracheal aspirate Viral viral clearance [DOI] 10.1038/s41598-022-18659-x PMC 바로가기 [Article Type] Article
Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링Article Published on 2022-08-042022-09-11 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제, [키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication [DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article
SARS-CoV-2 in infant urine and fecal samples after in utero COVID-19 exposureArticle Published on 2022-08-012022-11-16 Journal: Pediatric Research [Category] SARS, 치료기술, [키워드] acute respiratory syndrome Affect Care coronavirus Coronavirus disease 2019 COVID-19 detect Diagnosis Evidence examined Fecal sample fecal samples Guidance help Infant Infants Infection majority mother Nasopharyngeal swab pandemic patients Pregnancy pregnant women prenatal provide reported Result risk RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RT-PCR SARS-CoV-2 virus specimens Stage symptomatic disease Transmission transmission of SARS-CoV-2 transmitted Urine virus was collected with COVID-19 women [DOI] 10.1038/s41390-021-01822-x PMC 바로가기
Preoperative SARS-CoV-2 Screening Fails to Detect Viral Particles Prior to Airway Surgery수술 전 SARS-CoV-2 스크리닝은 기도 수술 전에 바이러스 입자를 감지하지 못함Article Published on 2022-08-012022-09-11 Journal: The Laryngoscope [Category] SARS, 치료기술, [키워드] adenoid adenoidectomy adenoidectomy. Asymptomatic asymptomatic patient asymptomatic patients Care Chain Reaction Child children collected conducted convenience sampling Course COVID COVID-19 cross-sectional study effect size Evidence evidence of Fail Infection Laryngoscope Level Logistic regression Nasopharyngeal swab nucleic acid Odds ratio Older Particle Patient pediatric polymerase chain reaction positive preoperative Prospective Study protocol question real-time reverse transcription-polymerase chain reaction reverse transcriptase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 viral particle SARS-CoV-2 viral particles Screening specimens surgery surgical These data tissue Total utility variable viral particle Viral particles Viral transmission was used [DOI] 10.1002/lary.29906 PMC 바로가기 [Article Type] Article
Phylogenetic analysis of human parainfluenza type 3 virus strains responsible for the outbreak during the COVID-19 pandemic in Seoul, South KoreaResearch article Published on 2022-08-012022-10-05 Journal: Journal of Clinical Virology [Category] 변종, [키워드] Acute respiratory infection aligned amino acid sequence analyses Analysis bootstrap C3a C3c cause Characteristics children circulating Cluster collected COVID-19 pandemic Emerging lineages Epidemic gene sequence Genetic Human Human Parainfluenza Virus 3 Infant Lineage molecular mutations nasopharyngeal swab specimen nucleotide sequence outbreak parainfluenza parainfluenza virus 3 Phylogenetic Phylogenetic analysis potential risk Protein ranged respiratory pathogen responsible Result South Korea specimens strain Substitution Support unique virus strain [DOI] 10.1016/j.jcv.2022.105213 [Article Type] Research article
Performance of saliva compared with nasopharyngeal swab for diagnosis of COVID-19 by NAAT in cross-sectional studies: Systematic review and meta-analysisResearch article Published on 2022-08-012022-10-05 Journal: Clinical biochemistry [Category] 변종, 진단, 치료기술, [키워드] 95 % CI amplification cohorts coronavirus disease COVID-19 cross-sectional database diagnose Diagnosis diagnosis of COVID-19 diagnostic Diagnostic accuracy highest Meta-analysis NAAT NAAT assay Nasopharyngeal swab NPs OVID performance QUADAS-2 Regression model Saliva saliva specimen searched sensitivity specificity specimens subgroup analysis suggested Support symptomatic systematic review tested variety was performed were used [DOI] 10.1016/j.clinbiochem.2022.08.004 [Article Type] Research article