Insights from the Infection Cycle of VSV-ΔG-Spike VirusArticle Published on 2022-12-192023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] electron tomography RNA virus Spike protein transmission electron microscopy vesicular stomatitis virus viral factories. [DOI] 10.3390/v14122828 PMC 바로가기
Mutational escape prevention by combination of four neutralizing antibodies that target RBD conserved regions and stem helixArticle Published on 2022-12-012023-07-10 Journal: Virologica Sinica [Category] COVID19(2023년), [키워드] adaptation Broadly neutralizing antibody SARS-CoV-2 Spike protein Stem helix. [DOI] 10.1016/j.virs.2022.11.005 PMC 바로가기
Evaluation of humoral immune responses induced by different SARS-CoV-2 spike trimers from wild-type and emerging variants with individual, sequential, and combinational delivered strategiesArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Antibody Response antibody response against autologous binding circulating coronavirus coronavirus disease COVID-19 Delta effective heterogenous homologous humoral immune response immunization immunogenicity indicated induce monovalent vaccine multivalent vaccine neutralizing antibody Neutralizing antibody response omicron produced regimen SARS-CoV-2 SARS-CoV-2 spike trimer significantly spike Spike protein spike trimer strain supported trimer Vaccination strategies Vaccination strategy Vaccine Vaccines variant Variant. variants viruses wild type wild-type [DOI] 10.1002/jmv.28081 PMC 바로가기
Pathogen-host adhesion between SARS-CoV-2 spike proteins from different variants and human ACE2 studied at single-molecule and single-cell levelsArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2-RBD acute respiratory syndrome addition adhere binding complex coronavirus Delta delta variant destabilized effective force spectroscopy highest host cell human ACE2 human Angiotensin-converting enzyme immunization Infection inhibit Interaction investigated molecular dynamics molecular mechanism monoclonal antibody Mutation mutations N501Y Neutralizing neutralizing antibody omicron pathogen-host adhesion. Probability produced RBD Receptor binding domain S477N SARS-CoV-2 SARS-CoV-2 spike protein single-cell single-cell level Spike protein tested the spike protein variant variants virus wild type [DOI] 10.1080/22221751.2022.2128887 PMC 바로가기
Rapid detection of SARS-CoV-2 variants of concern by single nucleotide polymorphism genotyping using TaqMan assaysArticle Published on 2022-12-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI Accuracy acute respiratory syndrome approach B.1.1.7 B.1.526 clinical setting Concordance coronavirus coronavirus disease 19 Coronavirus disease 19 (COVID-19) E484K evaluated genotyping mutations N501Y nasopharyngeal Negative predictive value New York City nonsynonymous patient population polymorphism positive positive sample predicted ranged Rapid Real-time reverse-transcription PCR residual RT-qPCR SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variant sensitivity Sequencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly lower single nucleotide specificity Spike protein submitted subset TaqMan TaqMan assay Thermofisher variant variants variants of concern. were used WGS whole genome [DOI] 10.1016/j.diagmicrobio.2022.115789 PMC 바로가기
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Jacareubin inhibits TLR4-induced lung inflammatory response caused by the RBD domain of SARS-CoV-2 Spike proteinArticle Published on 2022-12-012023-07-10 Journal: Pharmacological Reports [Category] COVID19(2023년), [키워드] coronavirus Lung inflammation RBD Spike protein TLR4. [DOI] 10.1007/s43440-022-00398-5 PMC 바로가기
From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19?우한-Hu-1 변종에서 XD 및 XE 변종까지: SARS-CoV-2 스파이크 단백질을 표적으로 하는 것이 여전히 COVID-19에 대한 약학적으로 적절한 옵션입니까?Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 변종, [키워드] contributing to COVID-19 COVID-19 pandemic death Efficacy feature glycoprotein hospitalisations infections milestone MPro Mutation mutations outbreak pandemic Paxlovid Protein reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant spike Spike protein Surface glycoprotein the SARS-CoV-2 the SARS-CoV-2 genome the Spike Treatment Vaccines variant viral surface Wuhan-Hu-1 XD variant XE variant. [DOI] 10.1080/14756366.2022.2081847 PMC 바로가기 [Article Type] Article
ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants고처리량 포화 돌연변이 유발에 의해 생성된 ACE2 미끼 수용체는 SARS-CoV-2 및 그 유행하는 변이체를 효율적으로 중화합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2-RBD binding approach binding binding affinity C-terminal cellular receptor changes in convalescent sera Critical critical point D614G decoy receptor domain Effect fused global pandemic glycosylation site High-throughput screening increase in Microarray monoclonal antibodies Mutagenesis mutations neutralization neutralize neutralized Omicron variant Point mutation prevalent protease Protein protein engineering. Pseudotyped virus RBD RBD binding RBD-ACE2 receptor Receptor binding domain rescued SARS-CoV-2 SARS-CoV-2 virus significantly single-cell soluble ACE2 Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential Treatment Vaccine variant variants viral entry viral spike protein wild-type [DOI] 10.1080/22221751.2022.2079426 PMC 바로가기 [Article Type] Article
Exploring SARS-CoV-2 Delta variant spike protein receptor-binding domain (RBD) as a target for tanshinones and antimalarialsArticle Published on 2022-12-012023-07-08 Journal: Natural Product Research [Category] COVID19(2023년), [키워드] bio-layer interferometry delta variant RBD SARS-CoV-2 Spike protein tanshinones. [DOI] 10.1080/14786419.2022.2057492 PMC 바로가기