Different impacts of common risk factors associated with thrombocytopenia in patients with hepatitis B virus and hepatitis C virus infectionArticle Published on 2022-10-012023-06-12 Journal: Biomedical journal [Category] B형 간염, Fulltext, [키워드] antiplatelet antibody cirrhosis Hepatitis B virus hepatitis C virus spleen thrombocytopenia [DOI] 10.1016/j.bj.2021.09.001 PMC 바로가기
Preparation and pre-clinical evaluation of flagellin-adjuvanted NOM vaccine candidate formulated with Spike protein against SARS-CoV-2 in mouse modelArticle Published on 2022-10-012022-11-15 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 진단, [키워드] 3D structure acute respiratory syndrome Analysis anti-S Antigen Antisera bind Cell Cell-mediated immune responses chimeric China Cluster coronavirus cytokine develop docking effective elicit ELISA ENhance evaluated expressed flagellin groups humoral IFN-γ IgG IL-10 IL-17 IL-22 IL-6 immune response immunoinformatics indicated Infection Interaction mice Ni-NTA NOM protein ORF3a outbreak performed pneumonia case preparation promoted Protein purified raised receptor S protein Salmonella SARS-CoV-2 significantly increased spike spleen TLR5 TNF-α Total vaccination Vaccine vaccine candidate vaccine candidates was selected were assessed Wuhan [DOI] 10.1016/j.micpath.2022.105736 PMC 바로가기
Fatal Form of COVID-19 in a Young Male Bodybuilder Anabolic Steroid Using: The First Autopsied CaseArticle Published on 2022-09-292022-11-15 Journal: Medicina [Category] SARS, 진단, [키워드] ACE-2 receptor anabolic anabolic androgenic steroids androgenic steroid atherosclerotic plaques Autopsy COVID-19 death Diffuse alveolar damage Endothelitis form Genetic Genetic predisposition histopathological HLA allele immune system Infection kidneys liver lung male microthrombi Myocardial infarction Myocardium organs pancreas Patient positive Pulmonary edema risk risk factor SARS-CoV-2 SARS-CoV-2 RT-PCR test spleen steroid Testosterone Thromboembolism tissue [DOI] 10.3390/medicina58101373 PMC 바로가기
Aseptic Abscess Syndrome in Rheumatoid Arthritis PatientArticle Published on 2022-09-272022-11-15 Journal: Medicina [Category] 진단, [키워드] abdominal pain abscess accompanied adalimumab Antibiotics Aseptic aseptic abscess syndrome Autoimmune diseases Bacteria characterized Clinical improvement Complete corticosteroid therapy COVID-19 infection disorder extension feature Fever IBD include Inflammatory Inflammatory bowel disease Inflammatory marker internal organ joints lack lesion lesions Leukocytosis liver Lungs microbe neutrophilic parasites Patient potentially life-threatening Practitioner Prednisone recognize reduction Remdesivir Rheumatoid rheumatoid arthritis sensitivity spleen Symptom syndrome systemic symptom tissue treated Treatment viruses weight loss [DOI] 10.3390/medicina58101354 PMC 바로가기
Tissue-specific pathway activities: A retrospective analysis in COVID-19 patientsArticle Published on 2022-09-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 receptor activity Affect affected Alter anticoagulation arachidonic acid calculated changed changes in cholesterol Coagulation complement COVID-19 COVID-19 patient COVID-19 patients example expressed highlight Inflammation less linolenic acid lung Map mapped mechanism metabolism molecular multiple tissues non-COVID-19 patient organ other tissue pathway pathway activity Pathways progression Protein proteomics data RAS regulatory pathway reported Retrospective analysis SARS-CoV-2 SARS-COV-2 infection spleen the disease thrombosis Thyroid tissue tissue-specific proteomics data. tissues virus WikiPathways Wilcoxon test [DOI] 10.3389/fimmu.2022.963357 PMC 바로가기
Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infectionArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] absence acute respiratory syndrome Administered administration animal model blocked bronchoalveolar C57BL/6 caused CD4 CD8 coronavirus Coronavirus disease-19 COVID-19 COVID-19 progression current demonstrated effective Efficacy elicited evaluated expressing full-length histopathological IgA antibody IgG immune responses Immunity immunogenic immunogenicity induce intramuscular intranasal intranasal delivery K18-hACE2 transgenic mice Local lung lung lesion lymph nodes mice modified vaccinia virus morbidity and mortality mucosal mucosal immune MVA nasal washe Nasal washes neutralizing antibody parental Prevent pro-inflammatory cytokine PROTECT Protective protective efficacy Protein responses Result S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2-specific immune response serum single dose spleen susceptible systemic immune response systemically T-cell immune response the SARS-CoV-2 Transmission undetectable upper respiratory tract vaccination Vaccine vaccine administration vaccine candidate vaccine candidates vaccine dose virus infection [DOI] 10.3389/fimmu.2022.995235 PMC 바로가기
Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunityArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] caused CD4+ CD4+ and CD8+ CD8+ T cell Cell cellular immunity Combination COVID-19 vaccine cytokine domain doses E. coli effective elicit elicited ELISA expressed female flow cytometry global pandemic granzyme groups IFN-γ IgG IgG1 IgG2a IL-12 IL-4 immune response immunized increase in induce infecting isotype long-lasting long-lasting neutralizing antibody lymphoproliferative mice N protein neutralization neutralization antibodies Neutralization antibody nucleocapsid percentage promoted Protective purified purified RBD quantified RBD recombinant Recombinant protein responses robust Saponin SARS-CoV-2 SARS-CoV-2 vaccine significantly spleen subcutaneously surrogate sVNT T cell response Test the SARS-CoV-2 Vaccine vaccine candidates vaccine group virus were measured [DOI] 10.3389/fimmu.2022.974364 PMC 바로가기
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cellsArticle Published on 2022-09-072022-11-16 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antibody antigen-presenting cells appear B cell biodistribution Cancer Cancer vaccine CD8 T cell changes in Clinical studies design-of-experiments methodology effective extrahepatic delivery histopathological Immune cell immune cell populations Immunity immunization Immunotherapy induce interferon liver LNP mechanism methodology mRNA mRNA expression non-human primate phagocyte provide response responses SARS-CoV-2 spleen stimulatory systemic T cell T cell response the vaccine Type vaccination Vaccine [DOI] 10.1016/j.ymthe.2022.07.007 PMC 바로가기
Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19SARS-CoV-2의 초기 분리물은 COVID-19의 형질도입된 마우스 모델에서 다른 병인을 초래합니다Article Published on 2022-08-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adenovirus alveolar inflammation BALB/c mice body weight Body weight loss Clinical sign Clinical signs COVID-19 dissemination expression followed by hACE2 hACE2 receptor Histopathology in vivo Infection isolate isolates kidney liver lung Lung histopathology Lungs mice Model mouse mouse model peaking post infection provide response Result resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus variant spleen subsequent recovery susceptible the SARS-CoV-2 virus transduced transduction undetectable Victoria viral variant Viral variants virulence virus weight loss [DOI] 10.3390/v14081769 PMC 바로가기 [Article Type] Article
Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administrationIV ChAdOx1 nCov-19 투여 후 혈소판 감소증 및 비장 혈소판 유도 면역 반응Article Published on 2022-08-042022-09-11 Journal: Blood [Category] SARS, 치료기술, 치료제, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adenovirus adenovirus vaccine adenovirus-based administration aggregate anatomic sites antibody antiplatelet antiplatelet antibody approach Autoimmune response Autoimmunity B-cell response binding ChAdOx1 ChAdOx1 nCoV-19 characterized circulating antibodies circulating antibody clinical entities Complication contribute coronavirus followed by glycoprotein heparin heparin-induced thrombocytopenia highlight immune response Immune thrombocytopenia in vitro in vivo model Intramuscular injection IV injection Macrophage macrophages marginal zone mechanism mice pathology Patient phagocytosed Platelet platelet activation platelet factor 4 Platelets potential mechanism prothrombotic state receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus spleen thrombocytopenia thrombosis Trigger vaccination Vaccine zone [DOI] 10.1182/blood.2021014712 PMC 바로가기 [Article Type] Article