Blocking EGFR with nimotuzumab: a novel strategy for COVID-19 treatment니모투주맙으로 EGFR 차단: COVID-19 치료를 위한 새로운 전략Clinical Trial Published on 2022-05-012022-09-12 Journal: Immunotherapy [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] antibody blocking cardiovascular disease clinical Comorbidity COVID-19 COVID-19 patients diabete drug EGFR evaluate fibrosis hypertension induce Inflammation Injury marker median age moderate Moderate COVID-19 monoclonal monoclonal antibody National nimotuzumab. overexpression Patient patients Prevent reduce Safe SARS-CoV-2 SARS-COV-2 infection Stat1 Treatment Trial was done [DOI] 10.2217/imt-2022-0027 PMC 바로가기 [Article Type] Clinical Trial
STAT1 and Its Crucial Role in the Control of Viral InfectionsReview Published on 2022-04-072023-07-01 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, [키워드] immune response interferon Stat1 viral infection [DOI] 10.3390/ijms23084095 PMC 바로가기 [Article Type] Review
Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposingSARS-COV-2 감염 및 약물 용도에 영향을 미치는 기능, 경로 및 조절제를 강조하는 숙주 게놈 바이오 마커의 계산 식별Article Published on 2022-03-112022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 신약개발, 치료제, [키워드] 3CL Analysis analyzed binding affinities Biomarker candidate drugs Computational biology and bioinformatics control sample COVID-19 CXCL2 daclatasvir DEGs differentially expressed gene docking drug Drug discovery drug target drugs Economy effective enrichment analysis FDA approved Drugs function functional functions genomic GUCY1A2 highlighting Host hub-genes identify IGF2 independent indicate infections Interaction investigated IRF7 Ivermectin KEGG pathway KLF6 life miRNA miRNAs molecular docking analysis NEDD9 network analysis PAG1 pandemic pathway Pathways performed PPI Protein Protein–protein interaction Proteins Radotinib Rapamycin receptor receptor protein receptor proteins receptors reduced RNA sequence SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seven signaling pathway signaling pathways significantly SNRPD2 stability Stat1 Systems biology tacrolimus the SARS-CoV-2 Thiostrepton TLR2 transcriptomics Treatment USP53 vaccination variants of SARS-CoV-2 ZFP36 [DOI] 10.1038/s41598-022-08073-8 PMC 바로가기 [Article Type] Article
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signalingResearch Published on 2022-03-052023-06-07 Journal: Virology Journal [Category] 신종인플루엔자, [키워드] A549 IFN influenza A virus IRF3 RUNX1 Stat1 [DOI] 10.1186/s12985-022-01764-8 PMC 바로가기 [Article Type] Research
Elimination of Aicardi–Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replicationAicardi-Goutières 증후군 단백질 SAMHD1 제거는 세포 선천 면역을 활성화하고 SARS-CoV-2 복제를 억제합니다Research Article Published on 2022-01-252022-09-10 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 치료제, [키워드] 293T ACE2, angiotensin-converting enzyme 2 activate activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect AGS, Aicardi–Goutières syndrome Antiviral ARHGEF5, Rho guanine nucleotide exchange factor 5 Baricitinib cDNA, complementary DNA Cell cell lines cells cellular characterized clearance coronavirus COVID-19, Coronavirus disease 2019 CRISPR Culture Degradation demonstrated DMEM, Dulbecco's modified Eagle's medium downregulated elevated Elimination expression FBS, fetal bovine serum FDA, US Food and Drug Administration Gene Expression Genetic HCoV-OC43, human coronavirus OC43 human coronavirus human coronavirus OC43 IFN IFN signaling IFN, interferon IFNs immune responses Infection innate immune response Innate immunity interferon interferons interferons (IFNs) IRF3, IFN regulatory factor 3 ISG, IFN-stimulated gene JAK inhibitor JAK pathway JAK, Janus kinase lack lentiviral Macrophage macrophages MDM, monocyte-derived macrophage model system MOI, multiplicity of infection Monocyte-derived macrophages mRNA NSP, nonstructural protein Pathways Phosphorylation Protein protein expression pSTAT1, phosphorylated form of STAT1 qRT–PCR, quantitative RT–PCR regulate Replication respiratory SAMHD1 SAMHD1, sterile alpha motif and histidine–aspartate domain–containing protein 1 SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2–infected patient SARS-CoV-2–infected patients SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown Signaling signaling pathway significantly increased Stat1 STAT1, signal transducer and activator of transcription 1 suppresse suppressed syndrome THP-1 tissue tissue culture Treatment upregulated Viral Viral protein Virus-like particle virus-like particles VLP, virus-like particle Vpx, viral protein X [DOI] 10.1016/j.jbc.2022.101635 PMC 바로가기 [Article Type] Research Article
The Potential Bioactive Components of Nine TCM Prescriptions Against COVID-19 in Lung Cancer Were Explored Based on Network Pharmacology and Molecular DockingMedicine Published on 2022-01-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ACE2 binding ADRB2 Against Analysis anti-SARS-CoV-2 baicalein China Chinese Chinese medicine component Compound COVID-19 cross database differentially expressed gene enrichment analysis expression FOS Frequency Gene ontology GeneCards highest HMOX1 Hydrogen bond hydrophobic ICAM1 identify IL6 immune immune function immune-related gene immunization ingredient Interaction JUN KEGG Kyoto lung adenocarcinoma molecular docking molecular target National Health Commission network network pharmacology NFKBIA NHC nine objective Occurrence overlapped overlapping performed Pharmacology platform positively correlated Potential potential mechanism prescription Result screened selected Stat1 target target gene TCM TCMSP therapeutic target UniProt viral transcription was used were used with COVID-19 [DOI] 10.3389/fmed.2021.813119 PMC 바로가기 [Article Type] Medicine
SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3SARS-CoV-2 스파이크는 인터페론 조절 인자 3을 표적으로 하여 선천적인 항바이러스 면역을 길항합니다Cellular and Infection Microbiology Published on 2022-01-102022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, [키워드] Activation acute respiratory syndrome Analysis antiviral immune response biochemical blocked Cell cells Co-expression analysis control cells Corona virus COVID-19 COVID-19 pathogenesis cytokine Cytokines disease disease severity downstream ectopic expression evade experiment expressing expression expression of SARS-CoV-2 facilitate Factor Genes Host IFN-I IFNβ immunoassay immunoassays indicated infections inhibitor Innate innate immune response Innate immunity interferon interferon regulatory factor IRF3 mechanism NF-κB Pathogenesis Pattern recognition pattern recognition receptor proteasomal degradation Protein remained respiratory RIG-I RIG-I antiviral RNA SARS-CoV-2 SARS-CoV-2 spike Severe Acute Respiratory Syndrome Corona Virus Signaling spike Stat1 stimulated suppressed targeting the SARS-CoV-2 transcription factor type I interferon Viral viral burden Viral RNA virus Virus Disease virus infections [DOI] 10.3389/fcimb.2021.789462 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λResearch Article Published on 2021-12-222022-10-30 Journal: mSphere [Category] Coronavirus, [키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting [DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article
TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infectionTREM-2는 SARS-CoV-2 감염에서 T 세포 반응의 센서이자 활성제입니다.Research Article Published on 2021-12-082022-09-14 Journal: Science Advances [Category] 유전자 메커니즘, 진단, [키워드] activate activated acute respiratory syndrome Antiviral binding Blood Clinical management complex coronavirus coronavirus disease COVID-19 cytokine description domain Drug discovery expressed Immunoglobulin induce Infection interferon-γ intrinsic knockout mice Limited lung M protein membrane membrane protein mouse hepatitis virus murine myeloid cell Necrosis pathway patients with COVID-19 Phosphorylation promoted Protein pseudovirus receptor recognize SARS-CoV-2 SARS-COV-2 infection Stat1 T cell T cell response T helper cell Transcription triggering Vaccine development viral clearance [DOI] 10.1126/sciadv.abi6802 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon ResponseCellular and Infection Microbiology Published on 2021-12-072022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antiviral immunity antiviral response association bind caused characterized coronavirus coronavirus 2 Coronavirus disease 2019 COVID-19 downstream evade evasion IFN-I IFN-I response increase inhibit interact interferon regulatory factor JAK1 Janus kinase 1 KPNA6 lack mechanism membrane protein molecular mechanism nuclear translocation patients performed respiratory response SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein Signaling signaling pathway spike Spread Stat1 subunit the spike protein therapeutic target Transcription Treatment Type type I interferon Viral protein [DOI] 10.3389/fcimb.2021.766922 PMC 바로가기 [Article Type] Cellular and Infection Microbiology