Long-Term Accuracy of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Interferon-γ Release Assay and Its Application in Household Investigation중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 인터페론-γ 방출 분석의 장기 정확도 및 가정 조사에서의 적용Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody responses antigen-specific T cell application applied Blood Blood donors cell-mediated immune cell-mediated immune response clinical assessment collected Contact convalescent coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 declined detect diagnostic epidemiological Epidemiological investigation evaluated exhibiting healthy blood donors household Households IFN-γ IgG IGRA Immunocompromised Immunocompromised patients index case index cases interferon investigation lithium Lithium heparin mitogen peptide peptide pool positive Post-infection Release remained respiratory responses robust SARS-CoV-2 SARS-CoV-2 antigen sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus stimulated T cells T-cell T-cell Response tested Vaccines variant Whole blood whole blood assay [DOI] 10.1093/cid/ciac045 PMC 바로가기 [Article Type] Article
Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood전혈에서 중증 급성 호흡기 증후군 코로나바이러스 2-특이적 T 세포 분석을 위한 신속한 사이토카인 방출 분석Article Published on 2022-08-242022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-receptor-binding domain antibody Blood samples characteristic clinical complicate Complication controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine cytokine Cytokine release assay diagnosed Diagnosis Diagnostic accuracy Donor EudraCT evaluated exhibited high accuracy IgG IgG levels Immunoglobulin Immunoglobulin G induction Infection interferon interferon γ memory memory response nucleocapsid Patient peptide peptides plasma Previous studies protocol Rapid receiver receiver operating characteristic Region Release remained respiratory SARS-CoV-2 seropositive serum severe acute respiratory syndrome Coronavirus spike stimulated study participant supernatant T cells T-cell T-cell immunity Trial vaccine doses waned Whole blood [DOI] 10.1093/infdis/jiac005 PMC 바로가기 [Article Type] Article
Efficacy of BCG Vaccination Against Respiratory Tract Infections in Older Adults During the Coronavirus Disease 2019 PandemicRandomized Controlled Trial Published on 2022-08-242022-10-04 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] 1.26 acute respiratory syndrome adverse events Against age Antibody Response Antibody titer assigned BCG BCG vaccination cellular clinical confidence interval control group coronavirus coronavirus disease COVID-19 COVID-19 infection cumulative cytokine response death diagnosed with COVID-19 end point EU Clinical Trial Follow-up Frequency groups had no hazard ratio Heterologous humoral immune responses Immunity incidence incidence of COVID-19 individuals Infection Influenza intracutaneous medical intervention multicenter Older Patient Placebo placebo-controlled trial polymerase chain positive primary end point Randomly required respiratory respiratory infections respiratory tract infection SARS-CoV-2 SARS-COV-2 infection secondary severity significantly stimulated subdistribution tested tract trained immunity Trial Tuberculosis vaccination Vaccine Volunteer volunteers [DOI] 10.1093/cid/ciac182 PMC 바로가기 [Article Type] Randomized Controlled Trial
Saliva as Blood Alternative in Therapeutic Monitoring of Teriflunomide-Development and Validation of the Novel Analytical MethodArticle Published on 2022-08-232022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 치료기술, [키워드] analyzed biologically active metabolite Blood can be used characterized collected Concentration correlation criteria dosage drug Effectiveness evaluated Good LC-MS/MS leflunomide life-threatening linear monitoring Non-invasive novel pharmacokinetic plasma quantification reduce regimen robust Saliva salivary SARS-CoV-2 pandemic Side effect stimulated Swab Teriflunomide therapeutic therapeutic drug Therapeutic Drug Monitoring validation Variability was obtained [DOI] 10.3390/ijms23179544 PMC 바로가기
A platform technology for generating subunit vaccines against diverse viral pathogensArticle Published on 2022-08-182022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] acting affinity tag animal model Antigen binding can be used Clamp conformation COVID-19 pandemic Ebola virus elicit epitope fusion fusion protein glycoprotein immune response immunologically Infectious disease MERS-CoV Microscopy middle molecular monoclonal antibody mRNA neutralising Neutralising Antibodies Nipah virus offer platform precursor prefusion purification reagent remained respiratory syndrome coronavirus shown size exclusion chromatography stability stimulated Streamline subunit Subunit vaccine subunit vaccines tested trimeric Vaccine vaccine candidate vaccine platform Viral Viral antigen viral challenge viral pathogen virus [DOI] 10.3389/fimmu.2022.963023 PMC 바로가기
SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregationSARS-CoV-2는 스트레스 과립의 분해를 손상시키고 ALS 관련 아밀로이드 응집을 촉진합니다Article Published on 2022-08-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 addition aggregation bind Cell cells cellular clearance experiment FUS Host host cells impair in vitro incorporation increased risk indicate infect Infection interactions Invasion mammalian cell mammalian cells Mutation N protein neurodegeneration NMR non-specific nucleocapsid nucleocapsid protein occur phase transition promote Protein Proteins reported SARS-CoV-2 SARS-COV-2 infection scenario stimulated Stress stress granule stress granules [DOI] 10.1007/s13238-022-00905-7 PMC 바로가기 [Article Type] Article
Microneedle-based two-step transdermal delivery of Langerhans cell-targeting immunoliposomes induces a Th1-biased immune responseLangerhans 세포 표적 면역리포좀의 미세바늘 기반 2단계 경피 전달은 Th1 편향 면역 반응을 유도합니다Article Published on 2022-08-012022-09-12 Journal: European journal of pharmaceutics and biopharmaceu [Category] MERS, 진단, [키워드] activate affecting antibody Antigen Antigen presentation CD11c Cellular immune response Combination Compliance DCs dendritic cell effective Efficiency expected immune immune response immunization Immunoliposomes IMPROVE in vivo indicated induce inhibit Langerhans cell Langerhans cell targeting Liposome maturation Microneedle monoclonal monoclonal antibody novel produced promoted significantly stimulated survival Th1-biased immune response the epidemic Transcutaneous Transcutaneous immunization. tumor growth Vaccine [DOI] 10.1016/j.ejpb.2022.06.004 PMC 바로가기 [Article Type] Article
RelCoVax®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in miceSARS-CoV-2에 대한 2개의 항원 소단위 단백질 백신 후보인 RelCoVax®는 마우스에서 강력한 면역 반응을 유도합니다Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] adjuvant adjuvants Administered alum aluminum aluminum hydroxide Antibody titer Antibody titers Antigen antigen exposure Cell Cellular immune response cellular immune responses Combination contribute COVID-19 pandemic CpG Delta delta variant demonstrated develop dominant dose regimen dual E. coli effective vaccine elicited Emergency use authorization evade evidenced glycoprotein heterologous expression hydroxide IFN-γ immune responses immunize immunized immunized mice in vitro induce mammalian cell mammalian cells mice Mutation N protein N proteins neutralize Neutralizing antibodies neutralizing antibody nucleocapsid prime and boost Protein RBD Receptor binding domain Region RelCoVax® S protein Safe SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus serum splenocyte splenocytes stimulated strain strong immune response subunit Subunit vaccine Th1 the SARS-CoV-2 virus vaccinated individuals Vaccine vaccine candidate vaccine candidates variants of SARS-CoV-2 viral strains virus entry [DOI] 10.1016/j.vaccine.2022.06.026 PMC 바로가기 [Article Type] Article
Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation Research Published on 2022-07-282022-10-05 Journal: ISME Communications [Category] 변종, 유전자 메커니즘, [키워드] accelerate Acinetobacter Antibiotic resistance antibiotic resistance gene antidepressant antimicrobial Arg ARGs ATP Bupropion cell membrane clinically Concentration demonstrated dissemination Duloxetine Extracellular Fluoxetine Gut Health Human increasingly Interaction microbial community potential risk promote reactive oxygen species Result sertraline significantly SOS response Spread stimulated Stress Transcription transfer translation [DOI] 10.1038/s43705-022-00147-y [Article Type] Research
Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article