stromal cell – Page 2 – Communicable Diseases Research

Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study

Clinical Trial

Published on 2022-05-262022-10-04
Journal: Stem Cell Research & Therapy [Category] 임상,

Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial

간질 세포 투여에 의한 급성 호흡 곤란 증후군의 회복(REALIST): 공개 라벨 용량 증량 1상 시험에 이어 무작위, 삼중 맹검, 할당 은폐, 위약 대조 2상 시험을 위한 구조화된 연구 프로토콜

Article

Published on 2022-05-132022-09-11
Journal: Trials [Category] COVID19(2023년), SARS, 임상,

[키워드] 1:1 acute respiratory distress acute respiratory distress syndrome administration allocation ARDS benefit blind causes Cell cells clinical clinical trial Cohort cohort of patient cohorts of patients concealed CONSORT COVID-19 distress dose dose-escalation early stage early stages Efficacy EudraCT Good immunomodulatory incidence include Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells moderate to severe MSC MSCs multicentre NHS number Open-label outcome outlined oxygenation index patients patients with moderate Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled placebo-controlled trial Practice produced protocol randomised rationale receive recruited recruitment repair reported Reporting respiratory distress Respiratory distress syndrome Serious Adverse Events severe ARDS Standard stromal cell stromal cells Study protocol syndrome therapy Trial triple-blind umbilical Umbilical cord
[DOI] 10.1186/s13063-022-06220-0 PMC 바로가기 [Article Type] Article

Advanced cell therapy with low tissue factor loaded product NestaCell® does not confer thrombogenic risk for critically ill COVID-19 heparin-treated patients

Research article

Published on 2022-05-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 유전자 메커니즘, 임상,

Regulation of Proinflammatory Molecules and Tissue Factor by SARS-CoV-2 Spike Protein in Human Placental Cells: Implications for SARS-CoV-2 Pathogenesis in Pregnant Women

인간 태반 세포에서 SARS-CoV-2 스파이크 단백질에 의한 전염증성 분자 및 조직 인자의 조절: 임산부의 SARS-CoV-2 발병에 대한 의미

Article

Published on 2022-04-072022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] ACE2 binding CCL2 CCL5 Cell cell line chemokine chemokines coagulation cascade complications contribute CTBs CXCL10 CXCL9 cytokine Cytokine storm Cytokines dysfunction elevate elevated ELISA Endothelial cell endothelial cells Express expression extrinsic Factor first trimester FUSE host cells Human IL-6 IL-8 immunohistochemical staining immunoreactivity Impaired pregnancy indicated induce infect Infection molecule outcomes Placenta placental placental dysfunction placental thrombosis pregnancies Pregnancy pregnancy complications pregnant women pro-inflammatory cytokine pro-inflammatory cytokine release pro-inflammatory cytokines proinflammatory Proinflammatory cytokine proinflammatory cytokines qPCR S-protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secreted significantly higher specimen spike Spike protein stromal cell stromal cells syncytiotrophoblast term the cytokine storm thrombosis tissue Tissue Factor TMPRSS2 TMPRSS2 level TMPRSS2 levels treated trophoblast Viral RNA virus was measured was performed were measured
[DOI] 10.3389/fimmu.2022.876555 PMC 바로가기 [Article Type] Article

Inhaled Placental Mesenchymal Stromal Cell Secretome from Two- and Three-Dimensional Cell Cultures Promotes Survival and Regeneration in Acute Lung Injury Model in Mice

2차원 및 3차원 세포 배양에서 흡입된 태반 중간엽 간질 세포 Secretome은 마우스의 급성 폐 손상 모델에서 생존 및 재생을 촉진합니다

Article

Published on 2022-03-222022-09-11
Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adult stem cells ALI model ARDS Cell cell spheroids cell-free therapy content coronavirus COVID-19 COVID-19 pandemic cultivation damaged death effective Effectiveness exhibited Extracellular Extracellular vesicles FIBRIN fibroblast healthcare histological immunomodulating in some Inflammatory Inflammatory diseases inhalation Inhaled investigated lung Lung inflammation Lung injury lung surfactant lung tissue Lungs management Measures mice Model morbidity and mortality Mortality Patient placental potential therapy problem proteomic regeneration regenerative respiratory distress Respiratory distress syndrome restored SARS-CoV-2 Secretome severe acute respiratory syndrome Coronavirus severe pneumonia stromal cell surfactant survival syndrome Taking therapeutic tissue regeneration
[DOI] 10.3390/ijms23073417 PMC 바로가기 [Article Type] Article

Safety and long-term improvement of mesenchymal stromal cell infusion in critically COVID-19 patients: a randomized clinical trial

Clinical Trial

Published on 2022-03-212022-10-05
Journal: Stem Cell Research & Therapy [Category] Coronavirus, SARS, 임상,

[키워드] acute COVID-19 biochemical Blood caused cell subpopulation Cell therapy clinical clinician complex consequence COVID-19 COVID-19 patients Critically ill CT scan cytokine D-dimer decrease diagnosed with COVID-19 disease disorder dose dosing interval double-blind early stages Efficacy extension ferritin Follow-up IL-6 immune dysregulation immunomodulatory property increase in Inflammatory intensive care intravenous dose invasive mechanical knowledge Laboratory testing lung damage lymphocyte Mesenchymal stromal cell Mesenchymal stromal cells MSC MSCs neutrophil organ parameter PASC Patient Placebo placebo-controlled clinical trial Postacute sequelae. Prevent Randomized randomized clinical trial reactive reduction reduction in Registered registry Safe Safety SARS-CoV-2 Severe case severe complication single-center stromal cell Surveillance Symptom Symptoms TCD4 therapy tissue damage tissue injury Treatment UC-MSC UC-MSCs umbilical Viral load with COVID-19
[DOI] 10.1186/s13287-022-02796-1 PMC 바로가기 [Article Type] Clinical Trial

Safety and efficacy study of allogeneic human menstrual blood stromal cells secretome to treat severe COVID-19 patients: clinical trial phase I & II

Randomized Controlled Trial

Published on 2022-03-072022-10-04
Journal: Stem Cell Research & Therapy [Category] MERS, SARS, 임상,

[키워드] 1:1 acute phase reactant Adverse adverse effect adverse event Allogeneic analyzed C-reactive protein caused CD4 CD8 chest imaging clinical symptom clinical trial control group COVID-19 Cytokine storm D-dimer declined demonstrated double-blind downregulation duration of hospitalization Efficacy Enrollment evaluate events ferritin FIVE GMP hospitalized patient hypoxia immune immune system increase in inflammatory lung disease injection intravenous infusion Intubated Laboratory parameters lymphocyte Lymphocyte count lymphopenia mechanism menstrual blood Menstrual blood stromal cells Mesenchymal stromal cell modulate MSCs New treatment outcomes Oxygen level Patient patients Phase I Placebo placebo-controlled clinical trial pulmonary involvement Randomized reduction Registered Result Safety safety endpoint SARS-CoV-2 Secretome severe COVID-19 Significant significantly stromal cell suppress survival rate survivor therapy treat treated Treatment treatment group Volume
[DOI] 10.1186/s13287-022-02771-w PMC 바로가기 [Article Type] Randomized Controlled Trial

Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial

Randomized Controlled Trial

Published on 2022-02-212022-10-04
Journal: Critical Care [Category] COVID19(2023년), MERS, SARS, 임상,

[키워드] 95% CI acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome analyzed ANCOVA ARDS assigned baseline cause change Coronavirus-2 Course COVID-19-associated ARDS double-blind double-blind trial Efficacy eligibility enrolled fractional inspired oxygen French Good-manufacturing practice high mortality intravenous intravenous infusion modified intention-to-treat multicenter multicentre NaCl not differ oxygen PaO Patient Placebo placebo group placebo-controlled trial Randomized Randomly receive recipient recruited recruitment Result screened Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome coronavirus-2 significantly stromal cell supplementary material syndrome the primary endpoint Treatment Trial UC-MSC UC-MSCs Umbilical cord-derived mesenchymal stromal cells
[DOI] 10.1186/s13054-022-03930-4 PMC 바로가기 [Article Type] Randomized Controlled Trial

Clinical efficacy and mechanism of mesenchymal stromal cells in treatment of COVID-19

Review

Published on 2022-02-072022-10-29
Journal: Stem Cell Research & Therapy [Category] COVID-19, COVID19(2023년), MERS, SARS,

Characterization of Leptin Receptor + Stromal Cells in Lymph Node

Original Research

Published on 2022-01-172023-08-30
Journal: Frontiers in Immunology [Category] E형 간염,

[키워드] Leptin receptor Lymph node matrix structure stromal cell type 2 diabetes
[DOI] 10.3389/fimmu.2021.730438 PMC 바로가기 [Article Type] Original Research