Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera중화 혈청에 대한 실험적 노출에 의한 SARS-CoV-2 주요 계통의 돌연변이 유도Article Published on 2022-07-212022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acquisition addition antibody characterisation escape mutation Evolution Evolution of SARS-CoV-2 human population immune evasion immune response Interaction Lineage Mutagenesis neutralisation neutralising neutralising antibody Neutralizing antibody response offer Perspective promoted required responsible SARS-CoV-2 sera species structural protein structural proteins target Viral viral adaptation viral variant [DOI] 10.1038/s41598-022-16533-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or γδ T cellsSARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질은 인간 수지상 세포 또는 γδ T 세포를 활성화하지 못합니다Article Published on 2022-07-142022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activate activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD3+ cell co-cultured contribute coronavirus COVID-19 patient COVID-19 patients Cytokines dendritic cell dendritic cells digestion downstream flow cytometry healthy donors immune immune cells Immunity indicated induce interferon interferon-γ interleukin-12 investigated Ligand mechanism mononuclear cell mononuclear cells nucleocapsid nucleocapsid protein Nucleocapsid proteins protease Protein SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus stimulated stimulatory structural protein structural proteins T cell T cell activation T cells thought Viral RNA virus [DOI] 10.1371/journal.pone.0271463 PMC 바로가기 [Article Type] Article
Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity1년 동안 SARS-CoV-2-특이적 T 세포 사이토카인 생성 반응에 대한 종단 평가는 질병 중증도와 관련된 더 큰 면역과 함께 다중 사이토카인 증식 반응의 지속성을 보여줍니다Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all subjects assessment average CD4 CD8 Cell Cell-mediated immunity clone coronavirus Coronaviruses Critical cytokine cytokine response Cytokines declined demonstrated dominant ELISPOT ELISpot assay envelope enzyme-linked immunosorbent epitope Epitopes Ex vivo female Frequency gamma interferon granzyme B greater GzmB highlight IFN-γ IL-2 immune immune modeling. Immunity immunodominant immunodominant epitope immunodominant epitopes induce Infection interferon interleukin interleukin 2 kill longitudinal male median membrane nucleocapsid observation other coronaviruses peaked persistence post-symptom onset potent predicted produced producing proliferative PSO reduced regions response robust SARS-CoV-1 SARS-CoV-2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe disease structural protein structural proteins subject survivor T cell T cell immunity T cell memory T cell response T cell responses T cells target cells Vaccine viral infections Year [DOI] 10.1128/jvi.00509-22 PMC 바로가기 [Article Type] Article
Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19COVID-19의 구강 증상의 병원성 메커니즘 및 다중 오믹스 분석Review Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Analysis bind caused clinical manifestation clinical manifestations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokines decrease droplets dysfunction dysregulation Factors Gustatory Host host cell host cells human ACE2 receptor immune immune cells immune dysregulation immune response Immunological analyses immunological analysis include infect Inflammation manifestation mount multi Multi-omics. multiple organ failure Numerous oral oral cavity pathogen pathogenic phenotype reported respiratory distress respiratory infectious disease S protein Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 Spread structural protein structural proteins syndrome the S protein Trigger virus Xerostomia [DOI] 10.3389/fimmu.2022.879792 PMC 바로가기 [Article Type] Review
SARS-CoV-2: phenotype, genotype, and characterization of different variantsSARS-CoV-2: 다양한 변이체의 표현형, 유전자형 및 특성화Article Published on 2022-06-172022-09-11 Journal: Cellular & Molecular Biology Letters [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha Amino acid amino acid sequence angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibiotics antiviral drugs B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 B.1.621 Beta can not Clusters coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta domain eliminated envelope epidemiological data exceptional family Coronaviridae Gamma Genetic variation Genome Genotype Glucocorticoids Health Organization help host cells IFN-α2b Immunoglobulin include infect Infection international public health Intravenous immunoglobulin Lambda membrane Nidovirales nucleocapsid omicron P.1 patients phenotype plasma plasma therapy positive Prevent Protein receptor risk of infection RNA RNA virus SARS-CoV-2 SARS-CoV-2 variants Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread structural protein structural proteins subtype the Coronaviridae therapy Transmission treat vaccination vaccine. variant Variation variations VoC WHO World Health Organization [DOI] 10.1186/s11658-022-00352-6 PMC 바로가기 [Article Type] Article
Atomic-Resolution Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal DomainSARS-CoV-2 뉴클레오캡시드 단백질 N-말단 도메인의 원자 분해능 구조Article Published on 2022-06-152022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] addition approach atomic bind binding experiment flexible genome organization genomic RNA Guidance in viral Infection information inhibitor means N- and C-termini N-terminal domain NMR NTD nucleocapsid offer pathogenicity Protein provide Region Replication RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus structural protein structural proteins Structure the SARS-CoV-2 the SARS-CoV-2 virus therapeutic intervention therapeutic interventions Vaccine development X-ray diffraction [DOI] 10.1021/jacs.2c03320 PMC 바로가기 [Article Type] Article
Evolution of SARS-CoV-2 in Spain during the First Two Years of the Pandemic: Circulating Variants, Amino Acid Conservation, and Genetic Variability in Structural, Non-Structural, and Accessory Proteins대유행의 첫 2년 동안 스페인에서 SARS-CoV-2의 진화: 구조적, 비구조적 및 부속 단백질의 순환 변이체, 아미노산 보존 및 유전적 다양성Article Published on 2022-06-072022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] Accessory accessory proteins acid Amino acid change circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants circulation conservation conserved COVID-19 death diagnostic tests Epidemic epidemic wave epidemic waves Epidemiology Europe Evolution Frequency genetic diversity genetic variability GISAID database had more highest Lineage lineages monitoring Mutation mutation frequency non-structural proteins pandemic Protein SARS-CoV-2 SARS-CoV-2 mutation sequence Spain Spanish Spread structural protein structural proteins study period the SARS-CoV-2 Therapies Vaccines Variability variability. Viral protein Year [DOI] 10.3390/ijms23126394 PMC 바로가기 [Article Type] Article
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNA. siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
Development of magnetic particle-based chemiluminescence immunoassay for measurement of SARS-CoV-2 nucleocapsid proteinSARS-CoV-2 뉴클레오캡시드 단백질 측정을 위한 자성입자 기반 화학발광 면역분석법 개발Article Published on 2022-04-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, 치료제, [키워드] addition antibody antigen detection BALB/c mice capture caused Cell cell line cells chemiluminescence Chemiluminescence enzyme immunoassay chemiluminescence immunoassay Clinical diagnosis coding sequence Coefficient of variance coronavirus disease Coronavirus disease 2019 COVID-19 detection antibody develop development diagnostic disease E. coli cell E. coli cells ELISA enzyme enzyme immunoassay enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated expressed expression fused global pandemic highest immunized immunoassay IPTG kDa mAb mAbs molecular weight monoclonal antibodies monoclonal antibody nucleic acid Nucleic acid detection nucleocapsid protein pandemic disease Precision Protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2. secreted selected sensitivity spleen Spread structural protein variance was obtained [DOI] 10.1016/j.jviromet.2022.114486 PMC 바로가기 [Article Type] Article
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Pandemic: Are Africa’s Prevalence and Mortality Rates Relatively Low?Review Article Published on 2022-02-262022-10-28 Journal: Advances in Virology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome advanced age Affect African allelic variants BCG binding complex condition conditions Consequences coronavirus disease Coronavirus-2 COVID-19 deficiency disease disease severity Epidemiology exacerbate expression Factor Frequency Genetic predisposition genetic susceptibility genetics global pandemic Health host cell host cell receptor host tissue hypothese Immunity include Infection infection risk inhibitor Interaction involved lack less lung Lungs majority malaria Mortality mortality rate Occurrence other organ outcome pandemic Pathogenesis pathology Population populations Prevalence protease Protein Rate reported respiratory risk factor SARS-CoV-2 Spread structural protein subsequent subunit the disease thought TMPRSS2 vaccination virus [DOI] 10.1155/2022/3387784 PMC 바로가기 [Article Type] Review Article