Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity1년 동안 SARS-CoV-2-특이적 T 세포 사이토카인 생성 반응에 대한 종단 평가는 질병 중증도와 관련된 더 큰 면역과 함께 다중 사이토카인 증식 반응의 지속성을 보여줍니다Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all subjects assessment average CD4 CD8 Cell Cell-mediated immunity clone coronavirus Coronaviruses Critical cytokine cytokine response Cytokines declined demonstrated dominant ELISPOT ELISpot assay envelope enzyme-linked immunosorbent epitope Epitopes Ex vivo female Frequency gamma interferon granzyme B greater GzmB highlight IFN-γ IL-2 immune immune modeling. Immunity immunodominant immunodominant epitope immunodominant epitopes induce Infection interferon interleukin interleukin 2 kill longitudinal male median membrane nucleocapsid observation other coronaviruses peaked persistence post-symptom onset potent predicted produced producing proliferative PSO reduced regions response robust SARS-CoV-1 SARS-CoV-2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe disease structural protein structural proteins subject survivor T cell T cell immunity T cell memory T cell response T cell responses T cells target cells Vaccine viral infections Year [DOI] 10.1128/jvi.00509-22 PMC 바로가기 [Article Type] Article
In Silico Studies on Zinc Oxide Based Nanostructured Oil Carriers with Seed Extracts of Nigella sativa and Pimpinella anisum as Potential Inhibitors of 3CL Protease of SARS-CoV-2SARS-CoV-2의 3CL 프로테아제의 잠재적 억제제로서 Nigella sativa 및 Pimpinella anisum의 종자 추출물을 포함하는 산화아연 기반 나노구조 오일 운반체에 대한 실리코 연구Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition applicability candidate carrier characterized clinical trials Compound compounds conformational change coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 docking explained Extract Health histogram imperative inhibitor investigated Ligand ligands MD simulation mixture molecular molecular docking molecular docking studies molecular dynamic simulation molecular dynamics Molecular dynamics simulation MPro nanostructure Nigella Nigella Sativa Oil oleuropein Oxide pandemic Pimpenella anisum Potential protease Protein Research RMSD RMSF SARS-CoV-2 SARS-CoV-2 main protease seed selected stability structural proteins the SARS-CoV-2 trajectory Vaccines variant Zinc zinc oxide Zinc oxide nanoparticles. [DOI] 10.3390/molecules27134301 PMC 바로가기 [Article Type] Article
Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19COVID-19의 구강 증상의 병원성 메커니즘 및 다중 오믹스 분석Review Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Analysis bind caused clinical manifestation clinical manifestations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokines decrease droplets dysfunction dysregulation Factors Gustatory Host host cell host cells human ACE2 receptor immune immune cells immune dysregulation immune response Immunological analyses immunological analysis include infect Inflammation manifestation mount multi Multi-omics. multiple organ failure Numerous oral oral cavity pathogen pathogenic phenotype reported respiratory distress respiratory infectious disease S protein Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 Spread structural protein structural proteins syndrome the S protein Trigger virus Xerostomia [DOI] 10.3389/fimmu.2022.879792 PMC 바로가기 [Article Type] Review
The SARS-CoV-2 helicase as a target for antiviral therapy: Identification of potential small molecule inhibitors by in silico modelling항바이러스 치료의 표적으로서의 SARS-CoV-2 헬리카제: in silico 모델링을 통한 잠재적인 소분자 억제제 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Acetylcysteine active site acute respiratory syndrome addition anti-inflammatory property Antiviral antiviral activity antiviral therapeutics antivirals binding free energy clavulanic acid Compound coronavirus coronavirus disease COVID-19 DHX9 DNA DNA2 expected Fatty acid fatty acids free energies Helicase Hepatitis hepatitis C highlighting identification identify in silico include inhibitor inhibitory activity initial lead leads Ligand MERS-CoV molecular dynamics Molecular dynamics simulation molecular dynamics simulations non-structural protein nsp13 nsp13. nucleoside performed reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 nsp13 selected sequence Severe acute respiratory syndrome small molecule inhibitor specific inhibitor specific inhibitors strain structural homology structural proteins Structure structures synthetic the SARS-CoV-2 utilised Vaccine variant was performed were used [DOI] 10.1016/j.jmgm.2022.108193 PMC 바로가기 [Article Type] Article
SARS-CoV-2: phenotype, genotype, and characterization of different variantsSARS-CoV-2: 다양한 변이체의 표현형, 유전자형 및 특성화Article Published on 2022-06-172022-09-11 Journal: Cellular & Molecular Biology Letters [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha Amino acid amino acid sequence angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibiotics antiviral drugs B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 B.1.621 Beta can not Clusters coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta domain eliminated envelope epidemiological data exceptional family Coronaviridae Gamma Genetic variation Genome Genotype Glucocorticoids Health Organization help host cells IFN-α2b Immunoglobulin include infect Infection international public health Intravenous immunoglobulin Lambda membrane Nidovirales nucleocapsid omicron P.1 patients phenotype plasma plasma therapy positive Prevent Protein receptor risk of infection RNA RNA virus SARS-CoV-2 SARS-CoV-2 variants Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread structural protein structural proteins subtype the Coronaviridae therapy Transmission treat vaccination vaccine. variant Variation variations VoC WHO World Health Organization [DOI] 10.1186/s11658-022-00352-6 PMC 바로가기 [Article Type] Article
Atomic-Resolution Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal DomainSARS-CoV-2 뉴클레오캡시드 단백질 N-말단 도메인의 원자 분해능 구조Article Published on 2022-06-152022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] addition approach atomic bind binding experiment flexible genome organization genomic RNA Guidance in viral Infection information inhibitor means N- and C-termini N-terminal domain NMR NTD nucleocapsid offer pathogenicity Protein provide Region Replication RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus structural protein structural proteins Structure the SARS-CoV-2 the SARS-CoV-2 virus therapeutic intervention therapeutic interventions Vaccine development X-ray diffraction [DOI] 10.1021/jacs.2c03320 PMC 바로가기 [Article Type] Article
Evolution of SARS-CoV-2 in Spain during the First Two Years of the Pandemic: Circulating Variants, Amino Acid Conservation, and Genetic Variability in Structural, Non-Structural, and Accessory Proteins대유행의 첫 2년 동안 스페인에서 SARS-CoV-2의 진화: 구조적, 비구조적 및 부속 단백질의 순환 변이체, 아미노산 보존 및 유전적 다양성Article Published on 2022-06-072022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] Accessory accessory proteins acid Amino acid change circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants circulation conservation conserved COVID-19 death diagnostic tests Epidemic epidemic wave epidemic waves Epidemiology Europe Evolution Frequency genetic diversity genetic variability GISAID database had more highest Lineage lineages monitoring Mutation mutation frequency non-structural proteins pandemic Protein SARS-CoV-2 SARS-CoV-2 mutation sequence Spain Spanish Spread structural protein structural proteins study period the SARS-CoV-2 Therapies Vaccines Variability variability. Viral protein Year [DOI] 10.3390/ijms23126394 PMC 바로가기 [Article Type] Article
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNA. siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small MoleculesSARS-CoV-2에 대한 새로 등장한 항바이러스 전략: 바이러스 단백질 구조 기능 해독에서 백신, 항체 및 소분자 개발까지Review Published on 2022-05-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antibody treatment Antiviral caused chemical compounds clustered regularly interspaced short palindromic repeats compounds contribute coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection CRISPR development disease pathogenesis DNA dual exploration focus function functional Health Health crisis host cells inactive Infection inhibitors life cycle molecule monoclonal antibodies monoclonal antibody mRNA nonstructural proteins palindromic repeat Particles peptide-based Protein protein-based vaccine Protein-based vaccines Proteins provide research findings respiratory RNA vaccines SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus single-stranded Strategy structural proteins structure-function systematic review target targeted therapy targets the SARS-CoV-2 genome therapeutic option Therapeutic strategies therapy Treatment Vaccine Vaccine development Vaccines Vaccines. Viral viral life cycle Viral protein Viral proteins viral replication virus [DOI] 10.3390/ijms23116083 PMC 바로가기 [Article Type] Review
Detection and discrimination of SARS-CoV-2 spike protein-derived peptides using THz metamaterialsTHz 메타물질을 이용한 SARS-CoV-2 스파이크 단백질 유래 펩타이드 검출 및 판별Article Published on 2022-04-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid analyzed component coronavirus detection diagnostic distribution domain effective examined frequencies Health hydropathy information investigated Metamaterials molecular peptide peptides Protein Quantitative analysis RBD RBD sequences Receptor-binding domain reproducibility Research residue risk SARS-CoV SARS-CoV molecular sensing SARS-CoV-2 SARS-CoV-2 spike selective sensitivity sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severe acute respiratory syndrome family species specificity Spread structural proteins Terahertz time-domain spectroscopy. the RBD unique viral entry [DOI] 10.1016/j.bios.2022.113981 PMC 바로가기 [Article Type] Article