Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in EthiopiaPlasmodium falciparum은 에티오피아에서 말라리아의 빠른 진단 검사를 피하기 위해 진화하고 있습니다.Article Published on 2021-09-272022-10-04 Journal: Nature Microbiology [Category] 말라리아, 바이오마커, 진단, [키워드] 95% confidence interval Antigen antigen detection applied approach blood sample Cohort cross-sectional survey deep sequencing Deletion diagnostic Diagnostic markers diagnostics Eritrea Horn of Africa identify immunoassay inversion malaria molecular Next-generation sequencing P. falciparum parasite participant PCR Plasmodium falciparum Positive selection Protein Rapid diagnostic test RDT RDTs recognize Region reveal selective South Structural variation subtelomeric Surveillance [DOI] 10.1038/s41564-021-00962-4 PMC 바로가기 [Article Type] Article
An international virtual hackathon to build tools for the analysis of structural variants within species ranging from coronaviruses to vertebrates코로나바이러스에서 척추동물에 이르는 종의 구조적 변이 분석을 위한 도구를 구축하기 위한 국제 가상 해커톤Software Tool Article Published on 2021-09-032022-09-11 Journal: F1000Research [Category] MERS, SARS, 변종, 진단, [키워드] Analysis annotation CNV college Community Diversity eight focus genomes genotyping group Human identify IMPROVE improvement Improvements Medicine NextGeneration Sequencing nine over participant provide Research SARS-CoV-2 second species Structural variant Structural variation Variation variations [DOI] 10.12688/f1000research.51477.2 PMC 바로가기 [Article Type] Software Tool Article
Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic TreatmentPhysiology Published on 2021-08-032022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] adaptive Amino acid amino-acid sequence dependency antibody antibody diversification B-cell candidate component consequence COVID-19 Critical defined determinant disease effective elicited epitope vaccines Evidence Evolution example explain gene sequence Genome glycosylation help highlight human cell humoral immune response hypothese immune response immune system Immunity immunogenic peptides immunomodulatory effects Implications Interpretation mechanism natural infection neutralizing antibody pandemic patient groups platform post-translational modification prophylactic treatment rarely recognized immune responses Safe SARS-CoV-2 SARS-COV-2 infection sequence somatic mutations Structural variation the vaccine translational Trial unique Vaccine design virus [DOI] 10.3389/fphys.2021.624675 PMC 바로가기 [Article Type] Physiology
Genetic and epigenetic control of ACE2 expression and its possible role in COVID-19ACE2 발현의 유전적 및 후성적 조절과 COVID-19에서의 가능한 역할Review Published on 2021-08-012022-09-11 Journal: Cell biochemistry and function [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 expression ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 caused Cell cell type Clinicians conducted contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 disease DNA methylation enzyme Epigenetic explain expressed expression expression pattern expression patterns Factors Gene Expression Genetic variant genetic variants Health Infection marker mechanism mechanisms MicroRNAs pandemic post-translational modification researcher SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Sex shown single-nucleotide polymorphism SNP SNPs Structural variation the SARS-CoV-2 [DOI] 10.1002/cbf.3648 PMC 바로가기 [Article Type] Review
Indels in SARS-CoV-2 occur at template-switching hotspotsResearch Published on 2021-03-202022-10-28 Journal: BioData Mining [Category] COVID-19, [키워드] Analysis breakpoint consensus sequence consensus sequences consequence COVID-19 pandemic de novo Deletion Evidence evolutionary dynamics Genome Genomics GISAID GISAID database heterogeneity homogeneity homologous Host hotspot IMPROVE INDEL indels independent insertion loci mechanism occur other coronaviruses predicted raw reads RdRP Recombination recombination event Region Regulatory replicate RNA RNA secondary structure RNA virus RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution secondary structure sequence Single nucleotide polymorphism Structural variation Structure supplementary material the SARS-CoV-2 Transcription Transcriptome TRS [DOI] 10.1186/s13040-021-00251-0 PMC 바로가기 [Article Type] Research
Insights on the Structural Variations of the Furin-Like Cleavage Site Found Among the December 2019–July 2020 SARS-CoV-2 Spike Glycoprotein: A Computational Study Linking Viral Evolution and InfectionMedicine Published on 2021-03-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] absence ACE-2 receptor Amino acid Analysis analyzed bind change cleaved Cluster coronavirus disease country COVID-19 deleted Epidemiology Evolution explain furin protease furin-like cleavage site Genome genomic Host host tropism infection clusters insight nine occurred pandemic Protein PRRA RBD SARS-CoV-2 SARS-CoV-2 (SARS2) SARS2 sequence Site spike spike glycoprotein Spike protein Structural variation structural variations the receptor-binding domain unique viral infectivity viral pathogenesis was performed [DOI] 10.3389/fmed.2021.613412 PMC 바로가기 [Article Type] Medicine
Hidden genomic features of an invasive malaria vector, Anopheles stephensi , revealed by a chromosome-level genome assembly염색체 수준 게놈 어셈블리를 통해 밝혀진 침습성 말라리아 벡터인 Anopheles stephensi의 숨겨진 게놈 특징Research Article Published on 2021-02-102024-07-27 Journal: BMC Biology [Category] 말라리아, [키워드] Anopheles stephensi Blood feeding Insecticide resistance malaria control Reference-quality assembly Structural variation transposable elements Y chromosome [DOI] 10.1186/s12915-021-00963-z PMC 바로가기 [Article Type] Research Article
Genotyping complex structural variation at the malaria-associated human glycophorin locus using a PCR-based strategyarticle Published on 2021-01-312024-09-01 Journal: Annals of Human Genetics [Category] 말라리아, [키워드] copy number variation genotyping glycophorin malaria Structural variation [Article Type] article
Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysisArticle Published on 2020-12-092022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Accuracy Analysis controls coronavirus 2 Coverage COVID-19 Critical detect elevated error rate Evidence Evolution facilitate frequencies Illumina improvement INDEL International Local Nanopore nanopore sequencing National Next-generation sequencing ONT Oxford Nanopore Technology Patient platform Precision provide public health respiratory RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 surveillance sensitivity sequence Sequencing sequencing reads short-read sequencing Single nucleotide variant SNVs specimen Structural variation supported Transmission Validity variant Viral genetics WGS whole-genome sequencing widespread [DOI] 10.1038/s41467-020-20075-6 PMC 바로가기 [Article Type] Article
SARS-CoV-2 exhibits intra-host genomic plasticity and low-frequency polymorphic quasispeciesArticle Published on 2020-08-112022-11-01 Journal: Journal of Clinical Virology [Category] COVID-19, MERS, SARS, [키워드] affecting alterations analyzed anti-viral drug antiviral agent assays Atypical Bioinformatics analysis changes China Chinese patient circulating clinical sample Coronavirus disease 2019 COVID-19 epidemic death diagnostic diagnostics effective Epidemic exhibit Frequency genomic genomic plasticity Genomic rearrangements genomic region Genomic variability highlight Host identify immunological infected with SARS-CoV-2 Intervention Intra-host variability majority Missense molecular molecular diagnostics NGS Novel coronavirus ORF1ab outbreak plasticity Pneumonia primer probe Quasispecies quasispecy Recombination Region reported S gene SARS-CoV-2 sensitivity single nucleotide variation SNV SNVs spike Spread Structural variation Transmission Vaccines Variation viral genes viral genome virus Wuhan [DOI] 10.1016/j.jcv.2020.104585 PMC 바로가기 [Article Type] Article