Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions
Article
[키워드] 6-Thioguanine
ACE2-expressing cells
acting
antiviral activity
antiviral drug
antivirals
approach
Betacoronavirus
betacoronaviruses
biochemical
Cell
complementary
coronavirus
demonstrated
early stage
ectopic expression
Effect
full-length
Genetic
GTPase
had no
HCoV-OC43
HPRT1
in vitro
infect
Infection
inhibit
inhibitor
lentivirus
nucleotide
oligosaccharide
outcome
progeny virion
Protein
pseudotyped
pseudovirus
Replication
SARS-CoV-2
selective
shown
spike
structural proteins
subgenomic RNA
target
Treatment
Viral diseases
viral genomes
Virus-like particle
VLPs
yielding
[DOI] 10.1371/journal.ppat.1010832 PMC 바로가기
[DOI] 10.1371/journal.ppat.1010832 PMC 바로가기