From Alpha to Omicron BA.2: New digital RT-PCR approach and challenges for SARS-CoV-2 VOC monitoring and normalization of variant dynamics in wastewaterArticle Published on 2022-11-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] approach circulation Concentration COVID-19 COVID-19 pandemic discrimination Epidemic fecal France Genome sequencing greater human population immune response immunized incidence Local MONITOR New normalization omicron Paris pathogenicity Patient PMMoV populations prevalent proportion public health resulting risk RT-PCR SARS-CoV-2 selection of variant Sequencing Severity of infection specific mutation Spread statistically strain subject suggested the SARS-CoV-2 genome Transmissibility Vaccination strategy Variability variant variants of concern Variation viral dynamics viral spread virus VoC VOCs wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157740 PMC 바로가기
The human host response to monkeypox infection: a proteomic case series studyArticle Published on 2022-11-082022-11-16 Journal: EMBO Molecular Medicine [Category] 유전자 메커니즘, [키워드] acute phase response Applying Biomarker case sery CFHR1 complement correlation COVID-19 disease severity Diseases endemic area healthy controls Host host response human host Infection Monkeypox virus outbreak overlap Patient plasma plasma protein Protein Proteins proteome proteomic proteomics provided Research similarities suggested suppressed the disease viral infection Viral infection. [DOI] 10.15252/emmm.202216643 PMC 바로가기
Intestinal Infarction in COVID-19 Pandemic: A Case SeriesOriginal Article Published on 2022-11-072022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] Abdominal CT Scan blood flow Clinical data coagulation disorder collected Complication coronavirus coronavirus disease COVID-19 described digestive system disrupt events Evidence headache Health Imam include Infection infection process intestinal Iran Ischemia Mashhad Medical Sciences mesenteric ischemia Necrosis novel operative organs pathological finding Patient patients hospitalized physician reported respiratory symptoms Reza risk factor Sery severe COVID-19 Severe COVID-19 Infection Severe COVID-19 pneumonia Spread suggested Symptom thrombosis university Vascular visceral with COVID-19 [DOI] 10.30699/IJP.2021.525280.2600 PMC 바로가기 [Article Type] Original Article
Cross-cultural comparison of nudging effects for environmental protection: A case-study of risk-averse attitudes toward disposable plasticsArticle Published on 2022-11-032022-11-16 Journal: PLoS ONE [Category] 비임상, [키워드] Analysis attribute benefit Canada caused conducted contributed correlated country COVID-19 cross-cultural Effect effect size effective Effects Factors identify IMPROVE individual information intervention effect Japan limit Linear regression model Machiavellianism positive attitude Randomized controlled trial risk significant effect suggested Support threat traits variety were measured [DOI] 10.1371/journal.pone.0277183 PMC 바로가기
Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trialArticle Published on 2022-11-022022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] approved assessment baseline Blood Cardiology case sery chronic fatigue syndrome chronic inflammation clinical clinical trial cognitive collected common COVID-19 defined domain double-blind dysfunction Effect effective Efficacy endothelial function Ethics evaluate fatigue healthy subject hyperbaric oxygen hypothese immunology IMPROVE Inconclusive independent individual initial institutional review board Long malaise mechanism monitoring board oxygen Oxygen therapy pandemic Patient peer-reviewed performed physical placebo-controlled placebo-controlled clinical trial positive Potential treatment product protocol Quality of life Questionnaires randomised rehabilitation medicine respiratory medicine (see thoracic medicine) secondary endpoint suggested survey Swedish Symptom syndrome the primary endpoint Treatment Trial VASCULAR MEDICINE. [DOI] 10.1136/bmjopen-2022-061870 PMC 바로가기
Repurposing of the herbal formulations: molecular docking and molecular dynamics simulation studies to validate the efficacy of phytocompounds against SARS-CoV-2 proteinsArticle Published on 2022-11-012022-11-16 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] Analysis binding affinity can be used Casuarinin Compound Corilagin COVID-19 docking result effective Efficacy evaluate function Herbal in silico Interaction investigated involved Ligand liquorice MD simulation molecular docking molecular dynamics Molecular dynamics simulation New polyherbal formulations Protein Proteins receptor receptor proteins Replication repurposing Result SARS-CoV-2 SARS-CoV-2 protein scored stability suggested the SARS-CoV-2 Traditional medicine Transcription Treatment Trial Validation. virus was performed [DOI] 10.1080/07391102.2021.1922095 PMC 바로가기
Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Respiratory Medicine [Category] SARS, 변종, 치료기술, [키워드] accelerate Alpha assessment assumption Bayesian Cohort cohort study Community Contact correlation Course COVID-19 COVID-19 case determine diagnosed early diagnosis eight eligible enrolled Evidence Final Guidance Hierarchical High-resolution household index cases Infection infection control Infectious virus initial IQR Isolation kinetic Lateral flow device LFD median Older Onset participant PCR positive PCR-confirmed plaque-forming unit post-symptom onset Probability quantified real-world data recruitment reduced released RT-PCR SARS-CoV-2 Self-isolation sensitivity Seven study population suggested Support survival Symptom symptom onset Symptoms the median the SARS-CoV-2 to define Transmission upper respiratory tract variant viral growth Viral load viral replication Viral RNA viral RNA load viral shedding virus were assessed [DOI] 10.1016/S2213-2600(22)00226-0 PMC 바로가기
An experimental test of the nicotinic hypothesis of COVID-19Article Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acetylcholine receptors acute respiratory syndrome binding binding competition assays cells competing complex coronavirus COVID-19 disease ectodomain effort expressed Hypothesis Infection Ligand nicotinic receptors pathophysiological mechanism peptides performed Rabies virus receptor receptors S1 domain SARS-CoV-2 SARS-CoV-2 spike protein Spike protein spike protein. suggested Symptom tested the SARS-CoV-2 unlikely virus [DOI] 10.1073/pnas.2204242119 PMC 바로가기
Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2PArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Beta challenge coronavirus COVID-19 COVID-19 vaccine Delta dose Effectiveness hamster hamster challenge study highest live SARS-CoV-2 Live virus lung MVC-COV1901 neutralization Neutralizing antibody titer Omicron variant pathology prefusion PROTECT pseudovirus recombinant regimen S-2P SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 vaccine spike Spike protein subunit Subunit vaccine suggested vaccination Vaccines variant Variant of concern. variants variants of concern virus Wuhan [DOI] 10.1093/infdis/jiac153 PMC 바로가기
An outlook on potential protein targets of COVID-19 as a druggable siteArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] approved cause claimed clinical trial combating contagious COVID-19 COVID-19 disease Cryo-electron microscopy Delta Efficacy feature genomic help host cell host protein infecting inhibit mechanism of action MERS-CoV Mutation non-structural proteins omicron pandemic Protein Protein target proteolytic cleavage raised Repurposed drug required SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein shown similarity spike Spike protein strain suggested the vaccine therapeutic drugs therapeutic interventions Vaccines. variants of SARS-CoV-2 viral infection virus Wuhan X-ray diffraction [DOI] 10.1007/s11033-022-07724-3 PMC 바로가기