Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents주요 변이체 표면 항원 암호화 유전자의 진화적 분석은 대륙 내 및 대륙 간 열원충의 개체군 구조를 나타냅니다.Research Article Published on 2021-02-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] absence Analysis Antigen approach asked biological significance complexity conserved country dataset deep sequencing demonstrated detect diagnostic Disease surveillance Diversity DNA DNA sequence DNA sequences domain East effort ENCODE Epidemics Evolution Gabon genomes Globalization health problem hidden hidden markov model HIV Host identify identity immunodominant implication infect Influenza isolate Local malaria malaria parasite malaria parasites Markov methodology Microbiologist MOST outcome parasite parasites pathogen Pathogens Plasmodium Plasmodium falciparum population immunity precluded presence or absence public health recent Recombination sensitivity sequence South America Spread subsequent surface antigen Surface Antigens Surveillance tested to define translational Transmission dynamics Uganda unique VAR var gene var genes variant variants West [DOI] 10.1371/journal.pgen.1009269 PMC 바로가기 [Article Type] Research Article
Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2 leading to universal blueprints for vaccine designs인공 지능은 백신 설계를 위한 보편적 청사진으로 이어지는 SARS-CoV-2의 면역원성 환경을 예측합니다.Article Published on 2020-12-232022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 신약개발, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome coronavirus allele Analysis analyzed Antigen presentation Antigen processing and presentation Applied immunology approach artificial intelligence autoimmune responses Biotechnology broad spectrum caused Cell cells chance Combination Computational biology and bioinformatics coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coverage COVID-19 Data integration database develop effective epitope Epitopes help HLA HLA haplotype HLA haplotypes HLA-A HLA-B HLA-DR homology host immune system hotspot human population identify immunization immunogenic immunology Immunotherapy individual input MHC class I MHC class II Mutation NEC nonsynonymous mutation Nonsynonymous mutations Novel coronavirus occurred pandemic predict predicted predictor Protein proteome reduce reduced Region respiratory robust SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 proteome sequence Sequence conservation severe acute respiratory syndrome coronavirus 2 statistically significant subset surface antigen T-cell epitope T-cell epitopes Vaccine Vaccine design Vaccines Viral Virtual drug screening virus [DOI] 10.1038/s41598-020-78758-5 PMC 바로가기 [Article Type] Article
N-Linked Glycan Sites on the Influenza A Virus Neuraminidase Head Domain Are Required for Efficient Viral Incorporation and ReplicationArticle Published on 2020-07-222023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] glycoprotein maturation IAV composition N-linked glycosylation sites NA stability surface antigen viral replication [DOI] 10.1128/JVI.00874-20 PMC 바로가기
Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial후보 중동 호흡기 증후군 코로나바이러스 바이러스 매개 백신의 안전성 및 면역원성: 용량 증량, 공개, 비무작위, 비통제, 1상 시험Article Published on 2020-07-012022-08-13 Journal: The Lancet. Infectious Diseases [Category] 임상, [키워드] absence adverse event AID All participant All participants antibody Antigen Arabian Peninsula assigned baseline cellular cellular and humoral immunogenicity cellular response ChAdOx1 ChAdOx1 MERS clinical clinical development clinical trial coronavirus Department described dose dose-escalation doses effective elicit ELISA enzyme enzyme-linked immunospot expressing finding FIVE Follow-up follow-up period full-length full-length spike surface glycoprotein funding healthy hepatitis B hepatitis B surface antigen hepatitis C hepatitis C antibodies hepatitis C antibody High-dose high-dose group HIV antibodies humans humoral humoral immunogenicity IgG immunogenicity ImmunoSpot Infection interferon interferon-γ-linked enzyme-linked immunospot intermediate-dose group Intervention Intramuscular injection low-dose Medicine MERS MERS-CoV MERS-CoV spike antigen Middle East Middle East respiratory syndrome Coronavirus Mild mild in severity moderate neutralisation neutralisation assay Neutralising Antibodies nine Occurrence Open-label Oxford participant Phase 1 phase 1 trial pre-vaccination test pre-vaccination tests pregnancy test progression proportion Pseudotyped virus public health Registered Relative risk reported resolved respiratory respiratory syndrome coronavirus response risk Safe Safety Saudi Arabia Serious Adverse Event Serious Adverse Events severe adverse event significant increase significantly higher simian adenovirus-vectored vaccine single dose Support surface antigen Surface glycoprotein T-cell tested Tolerability trials tropical medicine urinary pregnancy test vaccination vectored vaccine Viral viral particle Viral particles virus neutralising assay virus neutralising assays was done women [DOI] 10.1016/S1473-3099(20)30160-2 PMC 바로가기 [Article Type] Article
Increased Coffee Intake Reduces Circulating HBV DNA and HBsAg Levels in HBeAg-Negative Infection: A Cohort StudyArticle Published on 2019-09-012023-06-02 Journal: Viruses [Category] B형 간염, [키워드] Antiviral coffee Hepatitis B virus surface antigen Viral load [DOI] 10.3390/v11090808 PMC 바로가기 [Article Type] Article
Electronic Health Informatics Data To Describe Clearance Dynamics of Hepatitis B Surface Antigen (HBsAg) and e Antigen (HBeAg) in Chronic Hepatitis B Virus InfectionResearch Article Published on 2019-06-252023-06-03 Journal: mBio [Category] B형 간염, Fulltext, [키워드] Biomarker health informatics Hepatitis B virus surface antigen viral clearance [DOI] 10.1128/mBio.00699-19 PMC 바로가기 [Article Type] Research Article
Cryo-EM structure of native spherical subviral particles isolated from HBV carriersArticle Published on 2019-01-022023-06-17 Journal: Virus research [Category] B형 간염, [키워드] 3D reconstruction cryo-EM Hepatitis B virus Structural heterogeneity surface antigen [DOI] 10.1016/j.virusres.2018.10.015
Hepatitis B surface antigen loss and sustained viral suppression in Asian chronic hepatitis B patients: A community-based real-world studyArticle Published on 2017-12-012023-06-18 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Asians Hepatitis B virus oral antivirals surface antigen Viral suppression [DOI] 10.1111/jvh.12736
Hepatitis B core protein as a therapeutic targetReview Published on 2017-12-012023-06-18 Journal: Expert opinion on therapeutic targets [Category] B형 간염, [키워드] cccDNA Chronic Hepatitis B core antigen core protein core protein allosteric modulator cure HBx protein immune response nucleocapsid surface antigen Transcription translation Virology [DOI] 10.1080/14728222.2017.1397134 [Article Type] Review
Molecular and serological detection of occult hepatitis B virus among healthy hepatitis B surface antigen-negative blood donors in MalaysiaArticle Published on 2016-09-012023-06-16 Journal: African Health Sciences [Category] B형 간염, [키워드] Core antibody hepatitis B Occult hepatitis B infection polymerase chain reaction surface antigen [DOI] 10.4314/ahs.v16i3.6 PMC 바로가기