Pharmacological Inhibition of MMP3 as a Potential Therapeutic Option for COVID-19 Associated Acute Respiratory Distress SyndromeCOVID-19 관련 급성 호흡 곤란 증후군에 대한 잠재적인 치료 옵션으로서 MMP3의 약리학적 억제Article Published on 2021-01-012022-09-11 Journal: Infectious disorders drug targets [Category] MERS, 바이오마커, 치료기술, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS ARDS patient ARDS patients bacterial lipopolysaccharide Biomarker coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Early detection elevated high mortality inhibition Laboratory lipopolysaccharide matrix mediator mice MMP3 molecular mechanism molecular mechanisms option organ Patient plasma Potential Previous studies previous study progression reduce reduce mortality reported respiratory respiratory distress Respiratory distress syndrome severity stromelysin1 switch syndrome therapeutic treat virus infection [DOI] 10.2174/1871526520666201116100310 PMC 바로가기 [Article Type] Article
The Two-Way Switch Role of ACE2 in the Treatment of Novel Coronavirus Pneumonia and Underlying Comorbidities신종 코로나바이러스 폐렴 및 기저 동반 질환의 치료에서 ACE2의 양방향 전환 역할Review Published on 2020-12-312022-09-10 Journal: Molecules [Category] MERS, SARS, 치료제, [키워드] ACE ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition analyzed angiotensin angiotensin receptor blocker angiotensin-converting enzyme II (ACE2) anti-SARS-CoV-2 caused Comorbidities coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia Coronavirus-2 COVID-19 described domain drug Drug discovery enzyme II epithelial cells functional globe higher affinity host cells hot spot hypertension Infection information inhibitor interact Intervention lung failure Lung injury membrane-bound Mortality Novel coronavirus novel coronavirus pneumonia Patient pharmacological Pneumonia potential treatment option Protein pulmonary epithelial cells RAS receptor receptor blocker recombinant ACE2 Renin renin-angiotensin system renin-angiotensin system (RAS) respiratory role SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike protein Severe acute respiratory syndrome Severe acute respiratory syndrome (SARS) severe acute respiratory syndrome Coronavirus Spike protein Spread suggested switch the SARS-CoV-2 therapeutic strategy Treatment Viral [DOI] 10.3390/molecules26010142 PMC 바로가기 [Article Type] Review
Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a분자 역학은 CRISPR-Cas12a의 활성화를 유발하는 DNA 유도 동적 스위치를 보여줍니다Article Published on 2020-12-282022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료기술, 치료제, [키워드] Activation binding Cas9 catalytic site cleavage conformational coronavirus CRISPR Critical determinant Diagnosis DNA DNA binding domain dynamic Dynamics effort favor Genome IMPROVE induce joint molecular molecular dynamics MOST nonspecific Nuc nucleic acid Nucleic acid detection nucleic acids outcome REC regulator SARS-CoV-2 coronavirus specificity switch tendency the SARS-CoV-2 Viral Viral detection [DOI] 10.1021/acs.jcim.0c00929 PMC 바로가기 [Article Type] Article
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding DomainsACE2가 있거나 없는 SARS-CoV-2 스파이크의 Cryo-EM 구조는 수용체 결합 도메인의 엔도솜 위치를 매개하는 pH 의존적 스위치를 나타냅니다Article Published on 2020-12-092022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, [키워드] absence ACE2 ACE2 binding ACE2 receptor adopted Affect alteration binding antibody conformation COVID-19 Cryo-electron microscopy domain domains endosomal endosomal entry engage facilitate human ACE2 receptor immune evasion Interaction occur Pathways pH-dependent switch positioning RBD RBDs Receptor-binding domain Receptor-binding domain (RBD) required SARS-CoV-2 SARS-CoV-2 spike serological spike structural rearrangement Structure switch trimer type 1 fusion machine. virus entry [DOI] 10.1016/j.chom.2020.11.004 PMC 바로가기 [Article Type] Article
Clinical Evaluation of the cobas SARS-CoV-2 Test and a Diagnostic Platform Switch during 48 Hours in the Midst of the COVID-19 PandemicVirology Published on 2020-04-102022-10-30 Journal: Journal of Clinical Microbiology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome approach authorization automated Brescia clinical Cobas Cobas 6800 collected coronavirus correlation COVID-19 COVID-19 pandemic Cycle threshold value Diagnosis diagnostic drug Emergency EUA Euro FDA feasible food hour Immediate Infection Italy Laboratory nasopharyngeal swab sample pandemic performed platform protocol qualitative detection reagents Real-time PCR retrospective reverse transcription RNA extraction Roche RT-PCR Safe SARS-CoV-2 SARS-CoV-2 test switch System target Test U.S. FDA Universal Transport Medium [DOI] 10.1128/JCM.00599-20 PMC 바로가기 [Article Type] Virology
Switching Lamivudine with Adefovir Dipivoxil Combination Therapy to Entecavir Monotherapy Provides Better Viral Suppression and Kidney SafetyComparative Study Published on 2019-01-012023-06-19 Journal: International Journal of Medical Sciences [Category] B형 간염, [키워드] ETV, LAM and ADV combination therapy de novo kidney safety switch [DOI] 10.7150/ijms.28700 PMC 바로가기 [Article Type] Comparative Study
The global switch from trivalent oral polio vaccine (tOPV) to bivalent oral polio vaccine (bOPV): facts, experiences and lessons learned from the south-south zone; Nigeria, April 2016삼가형 경구 폴리오 백신(tOPV)에서 이가형 경구 폴리오 백신(bOPV)으로의 전환: 사실, 경험 및 남남 협력 지역에서 배운 교훈; 나이지리아, 2016년 4월Research Article Published on 2018-01-272024-08-01 Journal: BMC Infectious Diseases [Category] 폴리오, [키워드] bOPV switch tOPV [DOI] 10.1186/s12879-018-2963-6 PMC 바로가기 [Article Type] Research Article
Combination Therapy for Chronic Hepatitis B: Current Updates and PerspectivesReview Published on 2017-09-152023-06-19 Journal: Gut and liver [Category] B형 간염, [키워드] Add-on dual interferons Nucleos(t)ide analogue switch [DOI] 10.5009/gnl16215 PMC 바로가기 [Article Type] Review
Monitoring and Validation of the Global Replacement of tOPV with bOPV, April–May 2016tOPV에서 bOPV로의 전환 모니터링 및 검증, 2016년 4월–5월Article Published on 2017-07-012024-08-01 Journal: Nanoscale [Category] 폴리오, [키워드] eradication monitoring OPV polio switch [DOI] 10.1093/infdis/jiw558 PMC 바로가기
The Switch From Trivalent to Bivalent Oral Poliovirus Vaccine in the South-East Asia Region남아시아 지역에서 삼가형에서 이가형 경구 폴리오 백신으로의 전환Article Published on 2017-07-012024-08-01 Journal: Nanoscale [Category] 폴리오, [키워드] bivalent oral poliovirus vaccine immunization switch trivalent oral poliovirus vaccine [DOI] 10.1093/infdis/jiw602 PMC 바로가기